Luyong Zhang
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View article: Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy
Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy Open
Background Oestrogen receptor alpha (ERα) plays an important role in maintaining mitochondrial function and regulating metabolism in skeletal muscle. However, its alterations and potential mechanisms in Duchenne muscular dystrophy (DMD) re…
View article: LncRNA Gm35585 transcriptionally activates the peroxidase EHHADH against diet-induced fatty liver
LncRNA Gm35585 transcriptionally activates the peroxidase EHHADH against diet-induced fatty liver Open
Metabolic-dysfunction-associated steatotic liver disease is one of the most common chronic liver diseases worldwide and has no approved treatment thus far. Here we report that the hepatic overexpression of Gm35585, a novel lncRNA downregul…
View article: Hepatotoxicity Evaluation of Levornidazole and Its Three Main Impurities: Based on Structure–Toxicity Classification Prediction Combined with Zebrafish Toxicity Assessment
Hepatotoxicity Evaluation of Levornidazole and Its Three Main Impurities: Based on Structure–Toxicity Classification Prediction Combined with Zebrafish Toxicity Assessment Open
Levornidazole, a nitroimidazole compound, has been linked to hepatotoxic adverse effects in clinical settings. However, the hepatotoxicity of levornidazole and its impurities has not been fully elucidated. This study aimed to predict and e…
View article: Epithelial mitochondrial fission-mediated PANoptosis is crucial for ulcerative colitis and its inhibition by saquinavir through Drp1
Epithelial mitochondrial fission-mediated PANoptosis is crucial for ulcerative colitis and its inhibition by saquinavir through Drp1 Open
Ulcerative colitis (UC) is characterized by increased cell death in intestinal epithelial cell (IEC), which compromises gut barrier function and activates inflammation. Aberrant mitochondrial dynamics have been implicated in various forms …
View article: Silybin Meglumine Mitigates CCl4-Induced Liver Fibrosis and Bile Acid Metabolism Alterations
Silybin Meglumine Mitigates CCl4-Induced Liver Fibrosis and Bile Acid Metabolism Alterations Open
Background: Altered patterns of bile acids (BAs) are frequently present in liver fibrosis, and BAs function as signaling molecules to initiate inflammatory responses. Silybin meglumine (SLB-M) is widely used in treating various liver disea…
View article: N-butanol extract of Broussonetia papyrifera (L.) L′Hér. ex Vent root bark alleviates atopic dermatitis by targeting E3 ubiquitin ligase WWP1 to promote NLRP3 degradation
N-butanol extract of Broussonetia papyrifera (L.) L′Hér. ex Vent root bark alleviates atopic dermatitis by targeting E3 ubiquitin ligase WWP1 to promote NLRP3 degradation Open
The NE-BPRB and its primary bioactive constituent, CA, effectively inhibit the formation of the NLRP3 inflammasome and impede cell pyroptosis by promoting K48-linked ubiquitin-dependent proteasomal degradation of NLRP3 through binding to t…
View article: Diarylpropionitrile-stimulated ERβ nuclear accumulation promotes MyoD-induced muscle regeneration in mdx mice by interacting with FOXO3A
Diarylpropionitrile-stimulated ERβ nuclear accumulation promotes MyoD-induced muscle regeneration in mdx mice by interacting with FOXO3A Open
Duchenne muscular dystrophy (DMD) is an X-linked recessive progressive degenerative disease of skeletal muscle, characterized by intramuscular inflammation, muscle regeneration disorder and replacement of muscle with fibroadipose tissue. D…
View article: Proteasome activity inhibition mediates endoplasmic reticulum stress-apoptosis in triptolide/lipopolysaccharide-induced hepatotoxicity
Proteasome activity inhibition mediates endoplasmic reticulum stress-apoptosis in triptolide/lipopolysaccharide-induced hepatotoxicity Open
Triptolide (TP) is a major active and toxic composition of the Chinese medicine Tripterygium wilfordii Hook. F. (TWHF), exhibiting various therapeutic bioactivities. Among the toxic effects, the hepatotoxicity of TP deserves serious attent…
View article: Design, synthesis, and biological evaluation of novel highly selective non-carboxylic acid FABP1 inhibitors
Design, synthesis, and biological evaluation of novel highly selective non-carboxylic acid FABP1 inhibitors Open
View article: Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative splicing
Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative splicing Open
View article: Dual effects of Psoraleae Fructus on the liver: hepatoprotection or hepatoxicity?
Dual effects of Psoraleae Fructus on the liver: hepatoprotection or hepatoxicity? Open
Psoraleae Fructus, the dried mature fruit of the leguminous plant Psoralea corylifolia L., contains flavonoids, coumarins, monoterpene phenols, and benzofurans. It exhibits various pharmacological activities, including immune regulation, a…
View article: The paradox of Picroside II: As a natural antioxidant, but may instead futher aggravate liver injury by exacerbating mitochondrial oxidative stress
The paradox of Picroside II: As a natural antioxidant, but may instead futher aggravate liver injury by exacerbating mitochondrial oxidative stress Open
Background Picroside II (PII), an iridoid glycoside extracted from the rhizomes and stems of the genus Picroside, exhibits pronounced hepatoprotective properties. Pre-administration of PII protects against acute liver injury caused by D-ga…
View article: Targeting Moonlighting Enzymes in Cancer
Targeting Moonlighting Enzymes in Cancer Open
Moonlighting enzymes are multifunctional proteins that perform multiple functions beyond their primary role as catalytic enzymes. Extensive research and clinical practice have demonstrated their pivotal roles in the development and progres…
View article: Design, synthesis, and biological evaluation of first-in-class FABP1 inhibitors for the treatment of NASH
Design, synthesis, and biological evaluation of first-in-class FABP1 inhibitors for the treatment of NASH Open
View article: Tetrahedral framework nucleic acids for improving wound healing
Tetrahedral framework nucleic acids for improving wound healing Open
View article: Group 1 innate lymphoid cell activation via recognition of NKG2D and liver resident macrophage MULT-1: Collaborated roles in triptolide induced hepatic immunotoxicity in mice
Group 1 innate lymphoid cell activation via recognition of NKG2D and liver resident macrophage MULT-1: Collaborated roles in triptolide induced hepatic immunotoxicity in mice Open
Triptolide (TP) is the major bioactive component of traditional Chinese medicine Tripterygium wilfordii Hook. F., a traditional Chinese medicinal plant categorized within the Tripterygium genus of the Celastraceae family. It is recognized …
View article: Integrated network pharmacology and metabolomics to explore the mechanisms of Shenzao dripping pill against chronic myocardial ischemia
Integrated network pharmacology and metabolomics to explore the mechanisms of Shenzao dripping pill against chronic myocardial ischemia Open
View article: Double-Layer Skin Equivalents as Diffusion Models for Topical and Transdermal Drug Delivery Studies
Double-Layer Skin Equivalents as Diffusion Models for Topical and Transdermal Drug Delivery Studies Open
View article: Discovery of the First-in-Class Fxr/Ces2 Dual Modulator Le-77 for the Treatment of Irinotecan-Induced Delayed Diarrhea
Discovery of the First-in-Class Fxr/Ces2 Dual Modulator Le-77 for the Treatment of Irinotecan-Induced Delayed Diarrhea Open
View article: Epithelial Mitochondrial Fission-Mediated Panoptosis is Crucial for Ulcerative Colitis and its Targeting Inhibition by Saquinavir Through Drp1
Epithelial Mitochondrial Fission-Mediated Panoptosis is Crucial for Ulcerative Colitis and its Targeting Inhibition by Saquinavir Through Drp1 Open
View article: The role of peroxisome proliferator‐activated receptors in the regulation of bile acid metabolism
The role of peroxisome proliferator‐activated receptors in the regulation of bile acid metabolism Open
Bile acids are synthesized from cholesterol in the liver. Dysregulation of bile acid homeostasis, characterized by excessive accumulation in the liver, gallbladder and blood, can lead to hepatocellular damage and the development of cholest…
View article: Oncofetal SNRPE promotes HCC tumorigenesis by regulating FGFR4 expression through alternative splicing
Oncofetal SNRPE promotes HCC tumorigenesis by regulating FGFR4 expression through alternative splicing Open
Understanding the roles of spliceosome and splicing events during tumorigenesis opens new avenues for targeted therapies. Here, we identified that small nuclear ribonucleoprotein polypeptide E (SNPRE) is an oncofetal splicing factor, which…
View article: Correction: Li et al. Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling. Molecules 2019, 24, 110
Correction: Li et al. Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling. Molecules 2019, 24, 110 Open
The authors wish to make the following corrections to this paper [...]
View article: Design, synthesis, and biological studies of novel sulfonamide derivatives as farnesoid X receptor agonists
Design, synthesis, and biological studies of novel sulfonamide derivatives as farnesoid X receptor agonists Open
View article: Corrigendum to “Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth” [Redox Biol. 22 (2019) 101116]
Corrigendum to “Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth” [Redox Biol. 22 (2019) 101116] Open
View article: Discovery of the First-in-Class Intestinal Restricted FXR and FABP1 Dual Modulator ZLY28 for the Treatment of Nonalcoholic Fatty Liver Disease
Discovery of the First-in-Class Intestinal Restricted FXR and FABP1 Dual Modulator ZLY28 for the Treatment of Nonalcoholic Fatty Liver Disease Open
The prevalence of nonalcoholic steatohepatitis (NASH) is increasing rapidly worldwide, and NASH has become a serious problem for human health. Recently, the selective activation of the intestinal farnesoid X receptor (FXR) was considered a…
View article: Recent progress in aptamer-based microfluidics for the detection of circulating tumor cells and extracellular vesicles
Recent progress in aptamer-based microfluidics for the detection of circulating tumor cells and extracellular vesicles Open
Liquid biopsy is a technology that exhibits potential to detect cancer early, monitor therapies, and predict cancer prognosis due to its unique characteristics, including noninvasive sampling and real-time analysis. Circulating tumor cells…
View article: Expression profiles of lncRNAs and their possible regulatory role in monocrotaline-induced HSOS in rats
Expression profiles of lncRNAs and their possible regulatory role in monocrotaline-induced HSOS in rats Open
Aims: Long non-coding RNAs (lncRNAs) contribute to the regulation of vital physiological processes and play a role in the pathogenesis of many diseases. Monocrotaline (MCT) can cause large-scale outbreaks of toxic liver disease in humans a…
View article: Proteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium wilfordii multiglycoside in mice
Proteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium wilfordii multiglycoside in mice Open
Tripterygium wilfordii multiglycoside (GTW), extracted and purified from the peeled roots of T. wilfordii Hook.f. (TwHF), is a well-known traditional Chinese medicine and applied to various autoimmune diseases clinically. However, it has b…
View article: Design, synthesis, and biological studies of dual URAT1 inhibitor and FXR agonist based on benzbromarone
Design, synthesis, and biological studies of dual URAT1 inhibitor and FXR agonist based on benzbromarone Open