Li Ding
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View article: Machine learning-assisted network pharmacology reveals that the Chaihu-Longgu-Muli decoction modulates the inflammatory microenvironment to treat perimenopausal syndrome
Machine learning-assisted network pharmacology reveals that the Chaihu-Longgu-Muli decoction modulates the inflammatory microenvironment to treat perimenopausal syndrome Open
Background Chaihu-Longgu-Muli decoction (CLMD) is a traditional Chinese medicine formula that shows promise in alleviating symptoms related to premenstrual syndrome (PMS). However, the underlying mechanism remains unclear. This study uses …
View article: Lipid metabolism and osteonecrosis: unraveling causal mechanisms via multi-omics and mendelian randomization
Lipid metabolism and osteonecrosis: unraveling causal mechanisms via multi-omics and mendelian randomization Open
Osteonecrosis (ON), a debilitating condition marked by ischemic bone death, has been clinically linked to dysregulated lipid metabolism, yet the causal relationships and underlying genetic mechanisms remain poorly defined. This study emplo…
View article: Sleep disorders and the risk of cognitive decline or dementia: an updated systematic review and meta-analysis of longitudinal studies
Sleep disorders and the risk of cognitive decline or dementia: an updated systematic review and meta-analysis of longitudinal studies Open
This meta-analysis highlights sleep management as a pivotal modifiable factor in reducing the risk of all-cause cognitive decline. Systematic screening and early intervention for sleep disturbances should be prioritized as essential preven…
View article: Nanocatalytic Neuroprotection and Neurological Recovery Post‐Traumatic Brain Injury
Nanocatalytic Neuroprotection and Neurological Recovery Post‐Traumatic Brain Injury Open
Traumatic brain injury (TBI) is a severe neurological disorder requiring novel therapeutic strategies. We developed ultrasmall catalytic Ce 0.7 Zr 0.3 O 2 nanozymes (CZs) and investigated their neuroprotective potential in combination with…
View article: Adverse Dermatological Reaction to Mycophenolate Mofetil in a Patient with Systemic Lupus Erythematosus: A Case Report
Adverse Dermatological Reaction to Mycophenolate Mofetil in a Patient with Systemic Lupus Erythematosus: A Case Report Open
BACKGROUND Mycophenolate mofetil (MMF) is a disease-modifying antirheumatic drug (DMARD) that has been reported to cause skin rashes. Systemic lupus erythematosus (SLE) is also associated with typical discoid skin lesions. This report desc…
View article: 2D Indium‐Vacancy‐Rich ZnIn<sub>2</sub>S<sub>4</sub> Nanocatalysts for Sonocatalytic Cancer Suppression by Boosting Cancer‐Cell Pyroptosis
2D Indium‐Vacancy‐Rich ZnIn<sub>2</sub>S<sub>4</sub> Nanocatalysts for Sonocatalytic Cancer Suppression by Boosting Cancer‐Cell Pyroptosis Open
Sonocatalytic therapy is gaining interest for its non‐invasive nature, precise control, and excellent tissue penetration, making it a promising approach for treating malignant tumors. While defect engineering enhances electron and hole sep…
View article: Druggable genome-wide Mendelian randomization identifies therapeutic targets for metabolic dysfunction-associated steatotic liver disease
Druggable genome-wide Mendelian randomization identifies therapeutic targets for metabolic dysfunction-associated steatotic liver disease Open
CD33 inhibition can reduce MASLD risk, while MFGE8 activation may offer therapeutic benefits for MASLD treatment.
View article: Differentiation of pathological subtypes and Ki-67 and TTF-1 expression by dual-energy CT (DECT) volumetric quantitative analysis in non-small cell lung cancer
Differentiation of pathological subtypes and Ki-67 and TTF-1 expression by dual-energy CT (DECT) volumetric quantitative analysis in non-small cell lung cancer Open
Background To explore the value of dual-energy computed tomography (DECT) in differentiating pathological subtypes and the expression of immunohistochemical markers Ki-67 and thyroid transcription factor 1 (TTF-1) in patients with non-smal…
View article: Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy
Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy Open
Sonopiezocatalytic therapy is an emerging therapeutic strategy that utilizes ultrasound irradiation to activate piezoelectric materials, inducing polarization and energy band bending to facilitate the generation of reactive oxygen species …
View article: Spatial distribution and driving force analysis of soil heavy metals in the water source area of the middle route of the South-to-North Water Diversion Project
Spatial distribution and driving force analysis of soil heavy metals in the water source area of the middle route of the South-to-North Water Diversion Project Open
The South-to-North Water Diversion Project is crucial for ensuring water security in Beijing and balancing water resource distribution between China's northern and southern regions. The quality and distribution of soil heavy metals in the …
View article: Anti–Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency
Anti–Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency Open
Among patients with a variety of mycobacterial, bacterial, or fungal infections, the presence of neutralizing anti-interleukin-23 was associated with severe, persistent opportunistic infections. (Funded by the National Institute of Allergy…
View article: Polyethylenimine Triggers Dll4 Degradation to Regulate Angiogenesis In Vitro
Polyethylenimine Triggers Dll4 Degradation to Regulate Angiogenesis In Vitro Open
The Dll4-Notch signaling pathway plays a crucial role in the regulation of angiogenesis and is a promising therapeutic target for diseases associated with abnormal angiogenesis, such as cancer and ophthalmic diseases. Here, we find that po…
View article: Conventional and multi-omics assessments of subacute inhalation toxicity due to propylene glycol and vegetable glycerin aerosol produced by electronic cigarettes
Conventional and multi-omics assessments of subacute inhalation toxicity due to propylene glycol and vegetable glycerin aerosol produced by electronic cigarettes Open
Propylene glycol (PG) and vegetable glycerin (VG) are the most common solvents used in electronic cigarette liquids. No long-term inhalation toxicity assessments have been performed combining conventional and multi-omics approaches on the …
View article: ARHGAP9 knockdown promotes lung adenocarcinoma metastasis by activating Wnt/β-catenin signaling pathway via suppressing DKK2
ARHGAP9 knockdown promotes lung adenocarcinoma metastasis by activating Wnt/β-catenin signaling pathway via suppressing DKK2 Open
This study aims to elucidate the effect of ARHGAP9 on lung adenocarcinoma (LUAD) metastasis, and preliminarily explore its molecular mechanism. As a result, we found that ARHGAP9 was downregulated and correlated with poor prognosis of LUAD…
View article: Persistent neurological symptoms and elevated intracranial pressures in a previously healthy host with cryptococcal meningitis
Persistent neurological symptoms and elevated intracranial pressures in a previously healthy host with cryptococcal meningitis Open
Cryptococcal meningoencephalitis can occur in both previously healthy and immunocompromised hosts. Here, we describe a 55 year-old HIV-negative male with no known prior medical problems, who presented with three months of worsening headach…
View article: Chromatin Regulators as Prognostic Biomarkers In Patients With Pheochromocytomas And Paragangliomas
Chromatin Regulators as Prognostic Biomarkers In Patients With Pheochromocytomas And Paragangliomas Open
Chromatin regulators participated in tumorigenesis of various cancers while less research about its relationships with pheochromocytomas and paragangliomas. The aim of our study was to discover potential chromatin regulators as biomarkers …
View article: Study on the Efficacy of Polyethylene Filled SBMBBR Process for Treating Low Temperature Municipal Wastewater
Study on the Efficacy of Polyethylene Filled SBMBBR Process for Treating Low Temperature Municipal Wastewater Open
To tackle the hassle of low efficiency of low temperature denitrification in wintry weather in northern region,Sequencing Batch Moving Bed Biofilm Reactor (SBMBBR) used to be used for deep treatment of low temperature municipal wastewater …
View article: Development and validation of nomograms predicting postoperative survival in patients with chromophobe renal cell carcinoma
Development and validation of nomograms predicting postoperative survival in patients with chromophobe renal cell carcinoma Open
Objective The purpose of o ur study is to construct and validate nomograms that effectively predict postoperative overall survival and cancer-specific survival for patients with chromophobe renal cell carcinoma (chRCC). Method Clinical, so…
View article: Nanomedicine‐Enabled/Augmented Cell Pyroptosis for Efficient Tumor Nanotherapy
Nanomedicine‐Enabled/Augmented Cell Pyroptosis for Efficient Tumor Nanotherapy Open
The terrible morbidity and mortality of malignant tumors urgently require innovative therapeutics, especially for apoptosis‐resistant tumors. Pyroptosis, a pro‐inflammatory form of programmed cell death (PCD), is featured with pore formati…
View article: Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis
Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis Open
Background Anti GM-CSF autoantibodies (aAb) have been related to acquired pulmonary alveolar proteinosis (PAP) and described in cases of severe infections such as cryptococcosis and nocardiosis in previously healthy subjects. Whether there…
View article: Pharmacokinetic and pharmacodynamic similarity evaluation between an insulin glargine biosimilar product and Lantus® in healthy subjects: Pharmacokinetic parameters of both parent insulin glargine and M1 were used as endpoints
Pharmacokinetic and pharmacodynamic similarity evaluation between an insulin glargine biosimilar product and Lantus® in healthy subjects: Pharmacokinetic parameters of both parent insulin glargine and M1 were used as endpoints Open
Insulin glargine is a long-acting insulin analog, which plays an important role in the treatment of diabetes mellitus. Biosimilar products of insulin glargine can provide patients with additional safe, high-quality, and potentially cost-ef…
View article: Integrative analysis of DNA methylation and gene expression data for the diagnosis and underlying mechanism of Parkinson’s disease
Integrative analysis of DNA methylation and gene expression data for the diagnosis and underlying mechanism of Parkinson’s disease Open
Background Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder and the leading cause of disability in the daily activities. In the management of PD, accurate and specific biomarkers in blood for the ea…
View article: Detection of Neutralizing Anti‐Type 1 Interferon Autoantibodies
Detection of Neutralizing Anti‐Type 1 Interferon Autoantibodies Open
Autoantibodies (autoAbs) that neutralize type 1 interferons (T1IFNs) are a major risk factor associated with developing critical COVID‐19 disease and are most commonly found in individuals over age 70 and in patients with genetic or acquir…
View article: A distinct lipid metabolism signature of acute myeloid leukemia with prognostic value
A distinct lipid metabolism signature of acute myeloid leukemia with prognostic value Open
Background Acute myeloid leukemia (AML) is a highly aggressive hematological malignancy characterized by extensive genetic abnormalities that might affect the prognosis and provide potential drug targets for treatment. Reprogramming of lip…
View article: ZIC5 promotes human hepatocellular carcinoma cell proliferation through upregulating COL1A1
ZIC5 promotes human hepatocellular carcinoma cell proliferation through upregulating COL1A1 Open
ZIC5 could accelerate the proliferation, migration, and invasion of HCC cells through upregulating COL1A1. This is the first report that ZIC5 and COL1A1 are intrinsically linked, expanding new research ideas for subsequent HCC research.
View article: A Distinct Glucose Metabolism Signature of Lung Adenocarcinoma With Prognostic Value
A Distinct Glucose Metabolism Signature of Lung Adenocarcinoma With Prognostic Value Open
Background: Lung adenocarcinoma (LUAD) remains the most common type of lung cancer and is the main cause of cancer-related death worldwide. Reprogramming of glucose metabolism plays a crucial role in tumorigenesis and progression. However,…