Luyu Qi
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View article: Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide
Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide Open
Cisplatin is a DNA-targeting chemotherapeutic. Here we investigate how the cisplatin damaged gene loci are linked to specific protein-driven signalling pathways. Using forward chemical genetics methods, cisplatin damage to specific genes h…
View article: PRIM2 Promotes Cell Cycle and Tumor Progression in p53-Mutant Lung Cancer
PRIM2 Promotes Cell Cycle and Tumor Progression in p53-Mutant Lung Cancer Open
p53 is a common tumor suppressor, and its mutation drives tumorigenesis. What is more, p53 mutations have also been reported to be indicative of poor prognosis in lung cancer, but the detailed mechanism has not been elucidated. In this stu…
View article: Baicalin Targets HSP70/90 to Regulate PKR/PI3K/AKT/eNOS Signaling Pathways
Baicalin Targets HSP70/90 to Regulate PKR/PI3K/AKT/eNOS Signaling Pathways Open
Baicalin is a major active ingredient of traditional Chinese medicine Scutellaria baicalensis, and has been shown to have antiviral, anti-inflammatory, and antitumor activities. However, the protein targets of baicalin have remained unclea…
View article: G-quadruplex inducer/stabilizer pyridostatin targets <i>SUB1</i> to promote cytotoxicity of a transplatinum complex
G-quadruplex inducer/stabilizer pyridostatin targets <i>SUB1</i> to promote cytotoxicity of a transplatinum complex Open
Pyridostatin (PDS) is a well-known G-quadruplex (G4) inducer and stabilizer, yet its target genes have remained unclear. Herein, applying MS proteomics strategy, we revealed PDS significantly downregulated 22 proteins but upregulated 16 pr…
View article: G-quadruplex inducer/stabilizer pyridostatin targets SUB1 to promote cytotoxicity of a transplatinum complex
G-quadruplex inducer/stabilizer pyridostatin targets SUB1 to promote cytotoxicity of a transplatinum complex Open
Pyridostatin (PDS) is a well-known G-quadruplex (G4) inducer and stabilizer, yet its target genes have remained unclear. Herein, combining mass spectrometry based proteomics strategy with bioinformatics analysis, we revealed that PDS signi…
View article: G-quadruplex inducer/stabilizer pyridostatin targets SUB1 to promote cytotoxicity of a transplatinum complex
G-quadruplex inducer/stabilizer pyridostatin targets SUB1 to promote cytotoxicity of a transplatinum complex Open
Pyridostatin (PDS) is a well-known G-quadruplex (G4) inducer and stabilizer, yet its target genes have remained unclear. Herein, combining mass spectrometry based proteomics strategy with bioinformatics analysis, we revealed that PDS signi…
View article: Remote Sensing Image Zero-Watermark Algorithm Based on Bemd
Remote Sensing Image Zero-Watermark Algorithm Based on Bemd Open
In order to solve the problem of information security when acquiring and disseminating images and improve the performance of digital watermarking, this paper proposes a remote sensing image zero-watermarking algorithm based on Bidimensiona…
View article: Single cell imaging reveals cisplatin regulating interactions between transcription (co)factors and DNA
Single cell imaging reveals cisplatin regulating interactions between transcription (co)factors and DNA Open
A dual-modal microscopy imaging strategy was developed to investigate in situ the interactions between transcription (co)factors with cisplatin damaged DNA in single cells, showing that cisplatin lesions disrupted the interactions of Smad3…
View article: Genome-Wide Mapping of Cisplatin Damaged Gene Loci
Genome-Wide Mapping of Cisplatin Damaged Gene Loci Open
Cisplatin is a DNA targeting anticancer drug, yet its damaged gene loci have remained unclear. In the present work, combining affinity isolation and high throughput sequencing, we genome-widely mapped 17729 gene loci containing platination…
View article: Optics-Free Visualization of Proteins in Single Cells by Time of Flight-Secondary Ion Mass Spectrometry Coupled with Genetically Encoded Chemical Tags
Optics-Free Visualization of Proteins in Single Cells by Time of Flight-Secondary Ion Mass Spectrometry Coupled with Genetically Encoded Chemical Tags Open
In situ visualization of proteins of interest at single cell level is attractive in cell biology, molecular biology and biomedicine, which usually involves photon, electron or X-ray based imaging methods. Herein, we report an optics-free s…
View article: In Situ Visualizing the Recognition Between Proteins and Platinum-Damaged DNA in Single-Cells by Correlated Optical and Secondary Ion Mass Spectrometric Imaging
In Situ Visualizing the Recognition Between Proteins and Platinum-Damaged DNA in Single-Cells by Correlated Optical and Secondary Ion Mass Spectrometric Imaging Open
In situ visualization of the recognition and interaction between proteins and drug damaged DNA at single cell level is highly important for understanding the molecular mechanism of action of DNA targeting drugs, yet a great challenge. We h…
View article: Optics-Free Visualization of Proteins in Single Cells by Time of Flight-Secondary Ion Mass Spectrometry Coupled with Genetically Encoded Chemical Tags
Optics-Free Visualization of Proteins in Single Cells by Time of Flight-Secondary Ion Mass Spectrometry Coupled with Genetically Encoded Chemical Tags Open
In situ visualization of proteins of interest at single cell level is attractive in cell biology, molecular biology and biomedicine, which usually involves photon, electron or X-ray based imaging methods. Herein, we report an optics…
View article: Optics-Free Visualization of Proteins in Single Cells by Time of Flight-Secondary Ion Mass Spectrometry Coupled with Genetically Encoded Chemical Tags
Optics-Free Visualization of Proteins in Single Cells by Time of Flight-Secondary Ion Mass Spectrometry Coupled with Genetically Encoded Chemical Tags Open
In situ visualization of proteins of interest at single cell level is attractive in cell biology, molecular biology and biomedicine, which usually involves photon, electron or X-ray based imaging methods. Herein, we report an optics-free s…
View article: In Situ Visualizing the Recognition Between Proteins and Platinum-Damaged DNA in Single-Cells by Correlated Optical and Secondary Ion Mass Spectrometric Imaging
In Situ Visualizing the Recognition Between Proteins and Platinum-Damaged DNA in Single-Cells by Correlated Optical and Secondary Ion Mass Spectrometric Imaging Open
In situ visualization of the recognition and interactions between proteins and drug damaged DNA at single cell level is highly important for understanding the molecular mechanism of action of DNA targeting drugs, yet a great challenge. We …
View article: In Situ Visualizing the Recognition Between Proteins and Platinum-Damaged DNA in Single-Cells by Correlated Optical and Secondary Ion Mass Spectrometric Imaging
In Situ Visualizing the Recognition Between Proteins and Platinum-Damaged DNA in Single-Cells by Correlated Optical and Secondary Ion Mass Spectrometric Imaging Open
In situ visualization of the recognition and interactions between proteins and drug damaged DNA at single cell level is highly important for understanding the molecular mechanism of action of DNA targeting drugs, yet a great challenge. We …
View article: In Situ Visualizing the Recognition Between Proteins and Platinum-Damaged DNA in Single-Cells by Correlated Optical and Secondary Ion Mass Spectrometric Imaging
In Situ Visualizing the Recognition Between Proteins and Platinum-Damaged DNA in Single-Cells by Correlated Optical and Secondary Ion Mass Spectrometric Imaging Open
In situ visualization of the recognition and interaction between proteins and drug damaged DNA at single cell level is highly important for understanding the molecular mechanism of action of DNA targeting drugs, yet a great chall…
View article: [Tumor Associated Fibroblasts Promote PD-L1 Expression in Lung Cancer Cells].
[Tumor Associated Fibroblasts Promote PD-L1 Expression in Lung Cancer Cells]. Open
TAF promotes the growth and increases the expression of PD-L1 in H1975 and H520 cells. .
View article: [Altered Treg and IL-1A Expression in the Immune Microenvironment
of Lung Squamous-cell Cancer after EGFR Blockade].
[Altered Treg and IL-1A Expression in the Immune Microenvironment
of Lung Squamous-cell Cancer after EGFR Blockade]. Open
The autonomous (genetic) or systemic (pharmacologic) inhibition of EGFR signaling in tumor cells reduces tumor growth and Treg infiltration in the tumor microenvironment. An EGFR-dependent Treg function supports the growth of squamous canc…