Luyun Wang
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View article: Angiotensin-Converting Enzyme Inhibitors Mitigate Development of Chronic Persistent Cardiac Dysfunction Following Fulminant Myocarditis: A Multicenter Retrospective Study in China
Angiotensin-Converting Enzyme Inhibitors Mitigate Development of Chronic Persistent Cardiac Dysfunction Following Fulminant Myocarditis: A Multicenter Retrospective Study in China Open
ACE inhibitors may improve left ventricular (LV) function and prevent chronic persistent cardiac dysfunction in FM patients. Although they can partially reverse LV remodeling, increased LVEDD during long-term follow-up may reduce their the…
View article: The efficacy and safety of hydroxychloroquine in patients with chronic inflammatory cardiomyopathy: a multicenter randomized study (HYPIC trial)
The efficacy and safety of hydroxychloroquine in patients with chronic inflammatory cardiomyopathy: a multicenter randomized study (HYPIC trial) Open
ClinicalTrials.gov identifier: NCT05961202.
View article: An imaging genetics network model for clinical score assessment in Alzheimer's disease
An imaging genetics network model for clinical score assessment in Alzheimer's disease Open
Imaging genomics has recently emerged as a prominent focus in Alzheimer's disease (AD) research, showing great potential in predicting and diagnosing. In this paper, we propose a dual-stream imaging genetics network (DS-IGN) approach to AD…
View article: Development and validation of a predictive model for in-hospital mortality in patients with coronary heart disease and renal insufficiency
Development and validation of a predictive model for in-hospital mortality in patients with coronary heart disease and renal insufficiency Open
View article: The clinicopathologic features of fulminant myocarditis
The clinicopathologic features of fulminant myocarditis Open
To date, this largest cohort of histochemical analyses of FM, based on endomyocardial biopsy samples, has revealed dominant infiltration of innate immune cells in the early stage, followed by lymphocytes. This finding suggests that the act…
View article: Coupling relationship between glucose and oxygen metabolisms to serve as an imaging biomarker for Alzheimer’s disease
Coupling relationship between glucose and oxygen metabolisms to serve as an imaging biomarker for Alzheimer’s disease Open
CD33 rs3865444 polymorphism is closely associated with the risk of Alzheimer's disease (AD), and CD33 is part of the sialic acid-binding Ig-superfamily of lectins (SIGLECs). Immunostaining experiments in previous studies have confirmed the…
View article: Comprehensive profiling of tsRNAs in acute coronary syndrome: expression patterns, clinical correlations, and functional insights
Comprehensive profiling of tsRNAs in acute coronary syndrome: expression patterns, clinical correlations, and functional insights Open
Transfer RNA-derived small RNAs (tsRNAs) have emerged as potential biomarkers of various human diseases. However, the clinical utility and biological functions of tsRNA in acute coronary syndrome (ACS) remain poorly understood. To investig…
View article: Endomyocardial Biopsy: short- and long-term safety in myocarditis patients
Endomyocardial Biopsy: short- and long-term safety in myocarditis patients Open
Introduction: To assess the short-term and long-term outcomes of percutaneous endomyocardial biopsy (EMB) in patients with myocarditis and to identify the risk factors for EMB-related complications in this patient population. Methods: A re…
View article: Is nifekalant more effective than amiodarone in improving the clinical outcomes of catheter ablation in patients with persistent atrial fibrillation?
Is nifekalant more effective than amiodarone in improving the clinical outcomes of catheter ablation in patients with persistent atrial fibrillation? Open
For patients with PeAF that persists after initial catheter ablation, compared to amiodarone, administration of nifekalant could convert atrial fibrillation into atrial tachycardia, following by target ablation, has the potential to improv…
View article: ABCA1-Super Enhancer RNA Promotes Cholesterol Efflux, Reduces Macrophage-Mediated Inflammation and Atherosclerosis
ABCA1-Super Enhancer RNA Promotes Cholesterol Efflux, Reduces Macrophage-Mediated Inflammation and Atherosclerosis Open
We describe a previously uncharacterized ATP-binding cassette A1 super enhancer RNA (ABCA1-seRNA)-mediated cholesterol efflux. In addition, it promoted macrophage inflammatory cytokine release, and was causally correlated with coronary art…
View article: Brief Version of Chinese Society of Cardiology Guidelines on the Diagnosis and Treatment of Adult Fulminant Myocarditis
Brief Version of Chinese Society of Cardiology Guidelines on the Diagnosis and Treatment of Adult Fulminant Myocarditis Open
Review Brief Version of Chinese Society of Cardiology Guidelines on the Diagnosis and Treatment of Adult Fulminant Myocarditis Hongyang Shu, Chen Chen, Luyun Wang, Jiangang Jiang and Daowen Wang * Division of Cardiology, Department of Inte…
View article: A novel lncRNA GM47544 modulates triglyceride metabolism by inducing ubiquitination-dependent protein degradation of APOC3
A novel lncRNA GM47544 modulates triglyceride metabolism by inducing ubiquitination-dependent protein degradation of APOC3 Open
View article: Novel Alzheimer's disease subtypes based on functional brain connectivity in human connectome project
Novel Alzheimer's disease subtypes based on functional brain connectivity in human connectome project Open
View article: APOA1/C3/A4/A5 Gene Cluster at 11q23.3 and Lipid Metabolism Disorders: From Epigenetic Mechanisms to Clinical Practices
APOA1/C3/A4/A5 Gene Cluster at 11q23.3 and Lipid Metabolism Disorders: From Epigenetic Mechanisms to Clinical Practices Open
The APOA1/C3/A4/A5 cluster is an essential component in regulating lipoprotein metabolism and maintaining plasma lipid homeostasis. A genome-wide association analysis and Mendelian randomization have revealed potential associations between…
View article: Exploring the impact of a KCNH2 missense variant on Long QT syndrome: insights into a novel gender-selective, incomplete penetrance inheritance mode
Exploring the impact of a KCNH2 missense variant on Long QT syndrome: insights into a novel gender-selective, incomplete penetrance inheritance mode Open
Background Long QT syndrome (LQTS) is an inherited malignant arrhythmia syndrome that poses a risk of sudden death. Variants in the Potassium Voltage-Gated Channel Subfamily H Member 2 ( KCNH2 ) gene are known to cause Long QT syndrome thr…
View article: Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis
Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis Open
Novel strategies in intratumoral injection and emerging immunotherapies have heralded a new era of precise cancer treatments. The affinity of SARS-CoV-2 to ACE2 receptors, a feature which facilitates virulent human infection, is leveraged …
View article: Cardiac magnetic resonance imaging detection of intramyocardial hemorrhage in patients with ST-elevated myocardial infarction: comparison between susceptibility-weighted imaging and T1/T2 mapping techniques
Cardiac magnetic resonance imaging detection of intramyocardial hemorrhage in patients with ST-elevated myocardial infarction: comparison between susceptibility-weighted imaging and T1/T2 mapping techniques Open
SWI, as well as T1/T2 mapping, is a feasible and accurate approach for clinical diagnosis of IMH with excellent performance.
View article: Myocardial injury and related mortality in hospitalized patients with COVID-19 during the Omicron pandemic: new perspectives and insights
Myocardial injury and related mortality in hospitalized patients with COVID-19 during the Omicron pandemic: new perspectives and insights Open
View article: Dissociation of energy connectivity and functional connectivity in Alzheimer's disease is associated with maintenance of cognitive performance
Dissociation of energy connectivity and functional connectivity in Alzheimer's disease is associated with maintenance of cognitive performance Open
View article: Characteristics of Electrocardiogram Findings in Fulminant Myocarditis
Characteristics of Electrocardiogram Findings in Fulminant Myocarditis Open
Fulminant myocarditis (FM) is an acute and severe form of myocarditis with rapid progression and poor clinical outcomes in the absence of acute or chronic coronary artery disease. Electrocardiogram (ECG) abnormalities can provide prelimina…
View article: COVID-19 infection with complicated fulminant myocarditis: a case report
COVID-19 infection with complicated fulminant myocarditis: a case report Open
Herein, we report the case of a young female patient who suffered from myositis and heart failure due to fulminant myocarditis induced by the 2019 coronavirus disease (COVID-19). After receiving intra-aortic balloon pump (IABP) and immunom…
View article: Functional Brain Network Measures for Alzheimer’s Disease Classification
Functional Brain Network Measures for Alzheimer’s Disease Classification Open
Background: Alzheimer’s disease (AD) is an incurable neurodegenerative disease primarily affecting the elderly population. The therapy of AD depends heavily on an early diagnosis. In this study, our primary objective is to evaluate the cla…
View article: Author Correction: Parallel MR image reconstruction based on triple cycle optimization
Author Correction: Parallel MR image reconstruction based on triple cycle optimization Open
View article: Variant Angina is Associated with Myocarditis
Variant Angina is Associated with Myocarditis Open
Our findings demonstrate that VSA patients have significantly elevated plasma cytokine levels and myocardial and pericoronary inflammation, suggesting that VSA is associated with myocarditis. This study provides novel insights into the eti…
View article: Role of ABCA1 in Cardiovascular Disease
Role of ABCA1 in Cardiovascular Disease Open
Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most important proteins that maintains cholesterol homeostasis. ABCA…
View article: Parallel MR image reconstruction based on triple cycle optimization
Parallel MR image reconstruction based on triple cycle optimization Open
View article: Predictive classification of Alzheimer’s disease using brain imaging and genetic data
Predictive classification of Alzheimer’s disease using brain imaging and genetic data Open
For now, Alzheimer’s disease (AD) is incurable. But if it can be diagnosed early, the correct treatment can be used to delay the disease. Most of the existing research methods use single or multi-modal imaging features for prediction, rela…
View article: Genetic analysis and intracytoplasmic sperm injection outcomes of Chinese patients with congenital bilateral absence of vas deferens
Genetic analysis and intracytoplasmic sperm injection outcomes of Chinese patients with congenital bilateral absence of vas deferens Open
View article: The absolute and relative changes in high-sensitivity cardiac troponin I are associated with the in-hospital mortality of patients with fulminant myocarditis
The absolute and relative changes in high-sensitivity cardiac troponin I are associated with the in-hospital mortality of patients with fulminant myocarditis Open
View article: Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review Open
Pheochromocytoma multisystem crisis (PMC) is a potentially lethal emergency due to catecholamine secretion. The condition manifests as severe hypertension to intractable cardiogenic shock and has a high mortality rate. This study explored …