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View article: Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients Open
View article: Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia
Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia Open
View article: Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19
Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19 Open
View article: A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling Open
Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from SARS-CoV-2 or other causes acro…
View article: Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients Open
The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1-3) to more severe disease course (TG4) and death (TG5)…
View article: Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients Open
View article: COVID-19–associated Lung Microvascular Endotheliopathy: A “From the Bench” Perspective
COVID-19–associated Lung Microvascular Endotheliopathy: A “From the Bench” Perspective Open
Rationale: Autopsy and biomarker studies suggest that endotheliopathy contributes to coronavirus disease (COVID-19)-associated acute respiratory distress syndrome. However, the effects of COVID-19 on the lung endothelium are not wel…
View article: Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS Open
The immunological features that distinguish COVID-19-associated acute respiratory distress syndrome (ARDS) from other causes of ARDS are incompletely understood. Here, we report the results of comparative lower respiratory tract transcript…