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View article: High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata
High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata Open
Alopecia areata (AA) is an autoimmune disease in which cytotoxic T cells specifically target growing hair follicles. We used high-throughput TCR sequencing in the C3H/HeJ mouse model of AA and in human AA patients to gain insight into path…
View article: CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata
CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata Open
Alopecia areata (AA) is an autoimmune disease of the hair follicle that results in hair loss of varying severity. Recently, we showed that IFN-γ–producing NKG2D+CD8+ T cells actively infiltrate the hair follicle and are responsible for its…
View article: Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib
Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib Open
Baricitinib may be an effective treatment for AA and warrants further investigation in clinical trials.