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View article: Epidemiological characteristics of hand, foot and mouth disease in Pingdu, Shandong, China from 2013 to 2023 and DLNM analysis of its variation with temperature
Epidemiological characteristics of hand, foot and mouth disease in Pingdu, Shandong, China from 2013 to 2023 and DLNM analysis of its variation with temperature Open
Background The purpose of this study is to describe the epidemiological situation of HFMD in Pingdu over the past decade, and investigate the relationship between environmental factors, specifically temperature, and the incidence of hand, …
View article: Huangjia Ruangan granules with entecavir for fibrosis regression in Chroinc Hepatitis B: A multicenter, randomized, double-blind, phase II trial
Huangjia Ruangan granules with entecavir for fibrosis regression in Chroinc Hepatitis B: A multicenter, randomized, double-blind, phase II trial Open
Combining a 20g dose of the TCM formula HRG with ETV significantly enhances liver fibrosis regression in CHB patients.
View article: Robust Accessibility of Addressable Sites in Defective DNA Origami
Robust Accessibility of Addressable Sites in Defective DNA Origami Open
Owing to its unique programmability and addressability, DNA origami-based nanofabrication has been widely utilized in fields such as nanomedicine and nanophotonics. The accessibility of addressable sites on DNA origami structures is crucia…
View article: Magnetic Hierarchically Mesoporous UIO-66(Ce/Ti) Core-Shell Nanocomposites for Efficient Enrichment of Phosphopeptides
Magnetic Hierarchically Mesoporous UIO-66(Ce/Ti) Core-Shell Nanocomposites for Efficient Enrichment of Phosphopeptides Open
Hierarchically mesoporous metal-organic frameworks (HMUIO-66(Ce/Ti)) was designed and fabricated firstly by using a relatively rigid hydroxypropyl methylcellulose (HPMC) coupled with poly(ethylene oxide-b-propylene oxide-b-ethylene oxide, …
View article: Light‐Responsive Nanoemulsion‐Guided Assembly of Honeycomb Hierarchically Macro/mesoporous Metal–Organic Framework Nanoarchitectures
Light‐Responsive Nanoemulsion‐Guided Assembly of Honeycomb Hierarchically Macro/mesoporous Metal–Organic Framework Nanoarchitectures Open
Despite that soft template pathways are promising avenues for synthesizing hierarchically porous metal–organic framework (MOF) nanoparticles, smart‐responsive‐directed assembly strategies have been rarely extended to fabricate well‐defined…
View article: DISTURBANCE OBSERVER-BASED ADAPTIVE NETWORK EVENT-TRIGGERED BACKSTEPPING SYNCHRONIZATION CONTROL FOR FRACTIONAL ORDER CHAOTIC SYSTEMS
DISTURBANCE OBSERVER-BASED ADAPTIVE NETWORK EVENT-TRIGGERED BACKSTEPPING SYNCHRONIZATION CONTROL FOR FRACTIONAL ORDER CHAOTIC SYSTEMS Open
This paper supplies an event-triggered adaptive synchronization control scheme is proposed for fractional-order chaotic systems with unknown external disturbances. Neural networks are used to approximate unknown nonlinear functions. In ord…
View article: High-Speed Sequential DNA Computing Using a Solid-State DNA Origami Register
High-Speed Sequential DNA Computing Using a Solid-State DNA Origami Register Open
DNA computing leverages molecular reactions to achieve diverse information processing functions. Recently developed DNA origami registers, which could be integrated with DNA computing circuits, allow signal transmission between these circu…
View article: Synthesis of 3-Methyl-3-Buten-1-Ol by Supercritical CO2 in Coordination with HZSM-5 Catalyzed Formaldehyde-Isobutene Prins Reaction
Synthesis of 3-Methyl-3-Buten-1-Ol by Supercritical CO2 in Coordination with HZSM-5 Catalyzed Formaldehyde-Isobutene Prins Reaction Open
The reaction solvent and catalyst play essential roles in the Prins reaction for the synthesis of 3-methyl-3-buten-1-ol (MBO) from formaldehyde and isobutene. The reactivity of the solid base-catalyzed Prins condensation reaction by formal…
View article: Structural heterogeneity and plasticity of a Zr-based metallic glass modulated by high-temperature deformation
Structural heterogeneity and plasticity of a Zr-based metallic glass modulated by high-temperature deformation Open
Metallic glasses (MGs) are of high strength but limited plasticity at room temperature (RT) due to localized shear in the intrinsically heterogeneous structure. Here, we investigate the variation of structural heterogeneity and plasticity …
View article: Recombinant human thrombopoietin in alleviating endothelial cell injury in sepsis
Recombinant human thrombopoietin in alleviating endothelial cell injury in sepsis Open
rhTPO alleviates endothelial injury and inflammatory indices in sepsis, and may regulate septic endothelial cell injury through the PI3K/Akt pathway.
View article: Circular RNA MKLN1 promotes epithelial-mesenchymal transition in pulmonary fibrosis by regulating the miR-26a/b-5p/CDK8 axis in human alveolar epithelial cells and mice models
Circular RNA MKLN1 promotes epithelial-mesenchymal transition in pulmonary fibrosis by regulating the miR-26a/b-5p/CDK8 axis in human alveolar epithelial cells and mice models Open
Pulmonary fibrosis involves destruction of the lung parenchyma and extracellular matrix deposition. Effective treatments for pulmonary fibrosis are lacking and its pathogenesis is still unclear. Studies have found that epithelial-mesenchym…
View article: Programming crystallization kinetics of self-assembled DNA crystals with 5-methylcytosine modification
Programming crystallization kinetics of self-assembled DNA crystals with 5-methylcytosine modification Open
Self-assembled DNA crystals offer a precise chemical platform at the ångström-scale for DNA nanotechnology, holding enormous potential in material separation, catalysis, and DNA data storage. However, accurately controlling the crystalliza…
View article: Facile Fabrication of Carbon Nanotube Hollow Microspheres as Coating Fiber for Ultrasensitive Solid-Phase Microextraction of Phthalate Acid Esters in Tea Beverages
Facile Fabrication of Carbon Nanotube Hollow Microspheres as Coating Fiber for Ultrasensitive Solid-Phase Microextraction of Phthalate Acid Esters in Tea Beverages Open
The efficient extraction of phthalate acid esters (PAEs) is challenging due to their extremely low concentration, complicated matrices and hydrophilicity. Herein, hol-low microspheres, as an ideal coating, possesses significant potential f…
View article: Synthetic Biology and Control Theory: Designing Synthetic Biomolecular Controllers by Exploiting Dynamic Covalent Modification Cycle with Positive Autoregulation Properties
Synthetic Biology and Control Theory: Designing Synthetic Biomolecular Controllers by Exploiting Dynamic Covalent Modification Cycle with Positive Autoregulation Properties Open
The emerging field at the intersection of synthetic biology, network modelling, and control theory has grown in popularity in recent years. In this study, the aim is to design synthetic biomolecular controllers by exploiting the covalent m…
View article: The Design of 2DOF IMC-PID Controller in Biochemical Reaction Networks
The Design of 2DOF IMC-PID Controller in Biochemical Reaction Networks Open
DNA molecules can be adopted to design biomolecular control circuits that can effectively control biochemical reaction processes. However, the leak reaction in actual biochemical reactions causes a significant uncertainty for reactions. In…
View article: Hydrotalcite-calcined derivatives doped by zinc: A nucleophile-modified multifunctional catalyst for synthesis of propylene carbonate by cycloaddition
Hydrotalcite-calcined derivatives doped by zinc: A nucleophile-modified multifunctional catalyst for synthesis of propylene carbonate by cycloaddition Open
The composition of hydrotalcite-calcined derivatives doped by Zinc was optimized by uniform design. This derivatives further modified by KI nucleophile promoted the catalytic performance in terms of activity, selectivity and stability. N,N…
View article: Disturbance Observer-Based PID Control System Using DNA Strand Displacement and Its Application in Exponential Gate
Disturbance Observer-Based PID Control System Using DNA Strand Displacement and Its Application in Exponential Gate Open
Synthetic control circuits have demonstrated their effectiveness in molecular process control. However, current synthetic control circuits counteract the impact of disturbances by error signals. A disturbance suppression strategy that comb…
View article: Cascade PID Control Systems Based on DNA Strand Displacement With Application in Polarization of Tumor-Associated Macrophages
Cascade PID Control Systems Based on DNA Strand Displacement With Application in Polarization of Tumor-Associated Macrophages Open
Disturbances are widespread in biochemical systems. Nowadays, prevalent single-loop control strategies only take external disturbances into account. However, internal perturbations that threaten the stability of biochemical systems are inv…
View article: SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice
SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice Open
Fluid intelligence is a cognitive domain that encompasses general reasoning, pattern recognition, and problem-solving abilities independent of task-specific experience. Understanding its genetic and neural underpinnings is critical yet cha…
View article: Social deficits via dysregulated Rac1-dependent excitability control of prefrontal cortical neurons and increased GABA/glutamate ratios
Social deficits via dysregulated Rac1-dependent excitability control of prefrontal cortical neurons and increased GABA/glutamate ratios Open
Identifying symptom-specific convergent mechanisms for neurodevelopmental disorders is a promising strategy in advancing therapies. Here, we show that bidirectional dysregulation of Rac1 activity in the medial prefrontal cortex (mPFC) dict…