Nicholas Syn
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View article: Hepatocellular Carcinoma Surveillance and Survival in a Contemporary Asia-Pacific Cohort
Hepatocellular Carcinoma Surveillance and Survival in a Contemporary Asia-Pacific Cohort Open
Importance The etiologies of hepatocellular carcinoma (HCC) are changing. It is unclear whether the benefit of surveillance for people with HCC remains consistent given the changing etiologies of the disease. Objective To evaluate the asso…
View article: The Global Burden of Cirrhosis and Other Chronic Liver Diseases in 2021
The Global Burden of Cirrhosis and Other Chronic Liver Diseases in 2021 Open
Background and Aim The burden of cirrhosis and other chronic liver diseases has changed in recent years due to shifts in the contributing aetiologies. We estimated the burden of cirrhosis and other chronic liver diseases, including etiolog…
View article: Prevalence and longitudinal effects on mortality associated with spectrum of alcohol intake in steatotic liver disease: a United States population study
Prevalence and longitudinal effects on mortality associated with spectrum of alcohol intake in steatotic liver disease: a United States population study Open
ALD predominant patients have higher all-cause and cancer-related mortality risks than MASLD predominant patients but not CVD-related mortality. SLD is highly heterogeneous in clinical characteristics, prevalence, and mortality risks which…
View article: Accuracy of machine learning in predicting outcomes post-percutaneous coronary intervention: a systematic review
Accuracy of machine learning in predicting outcomes post-percutaneous coronary intervention: a systematic review Open
BACKGROUND: Recent studies have shown potential in introducing machine learning (ML) algorithms to predict outcomes post-percutaneous coronary intervention (PCI). AIMS: We aimed to critically appraise current ML models’ effectiveness as cl…
View article: Contemporary Incidence of Cognitive Impairment or Dementia in Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis
Contemporary Incidence of Cognitive Impairment or Dementia in Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis Open
Introduction: Despite the high prevalence of cognitive impairment or dementia post-coronary artery bypass grafting (CABG), the incidence of cognitive impairment or dementia post-CABG in contemporary practice is currently unclear. Therefore…
View article: Migraine and atrial fibrillation: a systematic review and meta-analysis
Migraine and atrial fibrillation: a systematic review and meta-analysis Open
Background: Patients with migraines, particularly those with auras, may present with stroke. Atrial fibrillation is a known risk factor for stroke. With common pathophysiological factors between migraines and atrial fibrillation, we aimed …
View article: Bridging bytes and biopsies: A comparative analysis of ChatGPT and histopathologists in pathology diagnosis and collaborative potential
Bridging bytes and biopsies: A comparative analysis of ChatGPT and histopathologists in pathology diagnosis and collaborative potential Open
Background and aims ChatGPT is a powerful artificial intelligence (AI) chatbot developed by the OpenAI research laboratory which is capable of analysing human input and generating human‐like responses. Early research into the potential app…
View article: Meta-analysis of cardiac imaging modalities for the diagnosis of left ventricular thrombus following acute myocardial infarction
Meta-analysis of cardiac imaging modalities for the diagnosis of left ventricular thrombus following acute myocardial infarction Open
Background The formation of left ventricular thrombus (LVT) in post-acute myocardial infarction (AMI) patient carries significant risk of systemic embolism. Hence, there is a need to adopt strategies aimed at accurate and early diagnosis o…
View article: The silent burden of non‐alcoholic fatty liver disease in the elderly: A global burden of disease analysis
The silent burden of non‐alcoholic fatty liver disease in the elderly: A global burden of disease analysis Open
Summary Background Non‐alcoholic fatty liver disease (NAFLD) represents a significant health threat worldwide. The growing trend towards an aging population, along with an alarming rise in obesity and diabetes, may have significant implica…
View article: Oncologic outcomes after breast-conserving surgery with radiotherapy <i>versus</i> mastectomy in patients with Paget’s disease of the breast: systematic review and meta-analysis
Oncologic outcomes after breast-conserving surgery with radiotherapy <i>versus</i> mastectomy in patients with Paget’s disease of the breast: systematic review and meta-analysis Open
Background The conventional approach to treatment for Paget's disease of the breast has been mastectomy, but there is an increasing trend to consider breast-conserving surgery (BCS) followed by radiotherapy (RT) in these patients. This stu…
View article: Development and validation of a novel risk score to predict overall survival following surgical clearance of bilobar colorectal liver metastases
Development and validation of a novel risk score to predict overall survival following surgical clearance of bilobar colorectal liver metastases Open
Background Bilobar liver metastases from colorectal cancer pose a challenge for obtaining a satisfactory oncological outcome with an adequate future liver remnant. This study aimed to assess the clinical and pathological determinants of ov…
View article: Patterns in Cancer Incidence Among People Younger Than 50 Years in the US, 2010 to 2019
Patterns in Cancer Incidence Among People Younger Than 50 Years in the US, 2010 to 2019 Open
Importance Emerging data suggest that the incidence of early-onset cancers, defined as cancers diagnosed in people younger than 50 years, is increasing, but updated data are limited. Objective To characterize the patterns in the incidence …
View article: Trial watch: immunotherapeutic strategies on the horizon for hepatocellular carcinoma
Trial watch: immunotherapeutic strategies on the horizon for hepatocellular carcinoma Open
The use of immune checkpoint inhibitors (ICIs) targeting PD-L1/PD-1 and CTLA-4 has transformed the oncology practice of hepatocellular carcinoma. However, only 25-30% of the patients with advanced HCC treated with atezolizumab-bevacizumab …
View article: Propensity-score Matched and Coarsened-exact Matched Analysis Comparing Robotic and Laparoscopic Major Hepatectomies
Propensity-score Matched and Coarsened-exact Matched Analysis Comparing Robotic and Laparoscopic Major Hepatectomies Open
Objective: To compare the outcomes between robotic major hepatectomy (R-MH) and laparoscopic major hepatectomy (L-MH). Background: Robotic techniques may overcome the limitations of laparoscopic liver resection. However, it is unknown whet…
View article: Supplementary Methods and Appendix from Real-Time Tumor Gene Expression Profiling to Direct Gastric Cancer Chemotherapy: Proof-of-Concept “3G” Trial
Supplementary Methods and Appendix from Real-Time Tumor Gene Expression Profiling to Direct Gastric Cancer Chemotherapy: Proof-of-Concept “3G” Trial Open
3G study protocol
View article: Supplementary Methods and Appendix from Real-Time Tumor Gene Expression Profiling to Direct Gastric Cancer Chemotherapy: Proof-of-Concept “3G” Trial
Supplementary Methods and Appendix from Real-Time Tumor Gene Expression Profiling to Direct Gastric Cancer Chemotherapy: Proof-of-Concept “3G” Trial Open
3G study protocol
View article: Data from Real-Time Tumor Gene Expression Profiling to Direct Gastric Cancer Chemotherapy: Proof-of-Concept “3G” Trial
Data from Real-Time Tumor Gene Expression Profiling to Direct Gastric Cancer Chemotherapy: Proof-of-Concept “3G” Trial Open
Purpose: The oxaliplatin plus S-1 and cisplatin plus S-1 regimens are interchangeably used in the management of advanced gastric cancer. The previously reported G-intestinal (G1) and G-diffuse (G2) intrinsic gene expression signatures show…
View article: Data from Real-Time Tumor Gene Expression Profiling to Direct Gastric Cancer Chemotherapy: Proof-of-Concept “3G” Trial
Data from Real-Time Tumor Gene Expression Profiling to Direct Gastric Cancer Chemotherapy: Proof-of-Concept “3G” Trial Open
Purpose: The oxaliplatin plus S-1 and cisplatin plus S-1 regimens are interchangeably used in the management of advanced gastric cancer. The previously reported G-intestinal (G1) and G-diffuse (G2) intrinsic gene expression signatures show…
View article: Robotic versus laparoscopic liver resection for huge (≥10 cm) liver tumors: an international multicenter propensity-score matched cohort study of 799 cases
Robotic versus laparoscopic liver resection for huge (≥10 cm) liver tumors: an international multicenter propensity-score matched cohort study of 799 cases Open
RLR and LLR can be performed safely for selected patients with huge liver tumours with excellent outcomes. There was no significant difference in perioperative outcomes after RLR or LLR.