Lydia F. Yamaguchi
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View article: Host-Derived Geranylgeraniol Shields Intraerythrocytic Stages of Malaria Parasites from Fosmidomycin
Host-Derived Geranylgeraniol Shields Intraerythrocytic Stages of Malaria Parasites from Fosmidomycin Open
View article: Phytochemical Composition and in Vitro Nematocidal Activity from Tropical Piper Species Essential on Caenorhabditis Elegans
Phytochemical Composition and in Vitro Nematocidal Activity from Tropical Piper Species Essential on Caenorhabditis Elegans Open
View article: Chemical constituents of <i>Coccoloba peltata</i> Schott leaves and their cytotoxic activities
Chemical constituents of <i>Coccoloba peltata</i> Schott leaves and their cytotoxic activities Open
Chromatographic fractionation of CH2Cl2:MeOH (1:1) extract of Coccoloba peltata Schott cultivated in Egypt afforded four compounds, lupeol acetate (1), ent-13-epi-manoyl oxide (2), 5…
View article: Antiproliferative potential of Plinia edulis leaves
Antiproliferative potential of Plinia edulis leaves Open
Plinia edulis, popularly known as ‘cambucá’, is used in Brazilian folk medicine to treat several conditions. The aim of this study was to evaluate the mutagenicity and cytotoxicity of cambucá leaf extract, as well as its antioxidant activi…
View article: Effects of Piper aduncum (Piperales: Piperaceae) Essential Oil and Its Main Component Dillapiole on Detoxifying Enzymes and Acetylcholinesterase Activity of Amblyomma sculptum (Acari: Ixodidae)
Effects of Piper aduncum (Piperales: Piperaceae) Essential Oil and Its Main Component Dillapiole on Detoxifying Enzymes and Acetylcholinesterase Activity of Amblyomma sculptum (Acari: Ixodidae) Open
Amblyomma sculptum is a species of tick in the family Ixodidae, with equids and capybaras among its preferred hosts. In this study, the acaricidal activity of the essential oil (EO) from Piper aduncum and its main component, Dillapiole, we…
View article: Toxicity and Teratogenic Potential of Piplartine from Piper tuberculatum Jacq. during Embryonic Development in Mice (Mus musculus)
Toxicity and Teratogenic Potential of Piplartine from Piper tuberculatum Jacq. during Embryonic Development in Mice (Mus musculus) Open
Piplartine, also known as piperlongumine, is a natural and biologically active amide alkaloid found in various Piper species within the Piperaceae family. It possesses numerous beneficial properties that can be leveraged in the development…
View article: Beyond the MEP Pathway: A novel kinase required for prenol utilization by malaria parasites
Beyond the MEP Pathway: A novel kinase required for prenol utilization by malaria parasites Open
A proposed treatment for malaria is a combination of fosmidomycin and clindamycin. Both compounds inhibit the methylerythritol 4-phosphate (MEP) pathway, the parasitic source of farnesyl and geranylgeranyl pyrophosphate (FPP and GGPP, resp…
View article: Plasticity in plant defense and the role of phytochemical dissimilarity in limiting specialist herbivory
Plasticity in plant defense and the role of phytochemical dissimilarity in limiting specialist herbivory Open
Phytochemical diversity is an effective plant defensive attribute, but much more research has focused on genetic and environmental controls of specific defensive compounds than phytochemical diversity per se . Documenting plasticity in phy…
View article: Antifungal activity against Fusarium oxysporum of quinolizidines isolated from three controlled-growth Genisteae plants: structure–activity relationship implications
Antifungal activity against Fusarium oxysporum of quinolizidines isolated from three controlled-growth Genisteae plants: structure–activity relationship implications Open
The Genisteae tribe belongs to the Fabaceae family. The wide occurrence of secondary metabolites, explicitly highlighting the quinolizidine alkaloids (QAs), characterizes this tribe. In the present study, twenty QAs ( 1 – 20 ), including l…
View article: In Vitro Activity of Essential Oils from Piper Species (Piperaceae) against Tachyzoites of Toxoplasma gondii
In Vitro Activity of Essential Oils from Piper Species (Piperaceae) against Tachyzoites of Toxoplasma gondii Open
Toxoplasmosis is a tropical and neglected disease caused by the parasitic protozoa Toxplasma gondii. Conventional treatment with sulfadiazine and pyrimethamine plus folinic acid, has some drawbacks, such as inefficacy in the chronic phase,…
View article: From optically pure pyridinium salts to some new dihydro-2H-oxazolo[3,2-a]pyridines
From optically pure pyridinium salts to some new dihydro-2H-oxazolo[3,2-a]pyridines Open
Treatment of 2,4,6-triphenylpiridinium salts, bearing a chiral β-hydroxy alkyl N-substituent with diluted aqueous sodium hydroxide afforded four new dihydrooxazolo[3,2a]pyridines,as an almost equimolar mixture of diastereomers. However, a …
View article: CCDC 2172080: Experimental Crystal Structure Determination
CCDC 2172080: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2172081: Experimental Crystal Structure Determination
CCDC 2172081: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2172082: Experimental Crystal Structure Determination
CCDC 2172082: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Isoprenoid alcohols utilization by malaria parasites
Isoprenoid alcohols utilization by malaria parasites Open
Plasmodium falciparum is the etiological agent of human malaria, one of the most widespread diseases in tropical and subtropical regions. Drug resistance is one of the biggest problems in controlling the disease, which leads to the need to…
View article: Interaction Gardens and Butterfly Catalogues: a Joint Strategy to Promote Capacity Development in Protected Areas and Reduce the Extinction of Experience in Cities
Interaction Gardens and Butterfly Catalogues: a Joint Strategy to Promote Capacity Development in Protected Areas and Reduce the Extinction of Experience in Cities Open
More than half of the world’s population live in cities. Increasing numbers of generations are now born and raised in urban landscapes with decreasing opportunities towards interacting with natural environments. This extinction of experien…
View article: Synthesis and Activity of 2-Acyl-cyclohexane-1,3-dione Congeners Derived from Peperomia Natural Products against the Plant p-Hydroxyphenylpyruvate Dioxygenase Herbicidal Molecular Target Site
Synthesis and Activity of 2-Acyl-cyclohexane-1,3-dione Congeners Derived from Peperomia Natural Products against the Plant p-Hydroxyphenylpyruvate Dioxygenase Herbicidal Molecular Target Site Open
Plastoquinone is a key electron carrier in photosynthesis and an essential cofactor for the biosynthesis of carotenoids. p-Hydroxyphenylpyruvate dioxygenase (HPPD) is a vital enzymatic step in plastoquinone biosynthesis that is the target …
View article: Presence of Phylloquinone in the Intraerythrocytic Stages of Plasmodium falciparum
Presence of Phylloquinone in the Intraerythrocytic Stages of Plasmodium falciparum Open
Malaria is one of the most widespread parasitic diseases, especially in Africa, Southeast Asia and South America. One of the greatest problems for control of the disease is the emergence of drug resistance, which leads to a need for the de…
View article: Are Brazilian bamboo species helpful for cognition and memory?
Are Brazilian bamboo species helpful for cognition and memory? Open
Background: Bamboo species has been used for centuries in Asian traditional medicine to treat mental disorders resulting from the aging process. Brazil has the greatest diversity of bamboos in the Americas, with a high degree of endemism, …
View article: Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs
Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs Open
Foundational hypotheses addressing plant–insect codiversification and plant defense theory typically assume a macroevolutionary pattern whereby closely related plants have similar chemical profiles. However, numerous studies have documente…
View article: Larvicidal Activity of Essential Oils From Piper Species Against Strains of Aedes aegypti (Diptera: Culicidae) Resistant to Pyrethroids
Larvicidal Activity of Essential Oils From Piper Species Against Strains of Aedes aegypti (Diptera: Culicidae) Resistant to Pyrethroids Open
The continuous and indiscriminate use of insecticides has been responsible for the emergence of insecticide resistant vector insect populations, especially in Aedes aegypti . Thus, it is urgent to find natural insecticide compounds with no…
View article: Ontogenetic Changes in the Chemical Profiles of Piper Species
Ontogenetic Changes in the Chemical Profiles of Piper Species Open
The chemical composition of seedlings and adult plants of several Piper species were analyzed by 1H NMR spectroscopy combined with principal component analysis (PCA) and HPLC-DAD, HPLC-HRESIMS and GC-MS data. The chromatographic profile of…
View article: Description of three new species of Geometridae (Lepidoptera) using species delimitation in an integrative taxonomy approach for a cryptic species complex
Description of three new species of Geometridae (Lepidoptera) using species delimitation in an integrative taxonomy approach for a cryptic species complex Open
The genus Eois Hübner (Geometridae: Larentiinae) comprises 254 valid species, 217 of which were described from the Neotropics and 31 of those having their type locality in Brazil. Since this species rich genus has never been revised, and m…
View article: From the leaf to the community: Distinct dimensions of phytochemical diversity shape insect–plant interactions within and among individual plants
From the leaf to the community: Distinct dimensions of phytochemical diversity shape insect–plant interactions within and among individual plants Open
Plant secondary chemistry is known to be an important driver of plant–insect community structure across ecological scales. Recently, the concept of phytochemical diversity (PD) has been introduced to help describe variation in plant second…
View article: Chemical and Genotypic Variations in Aniba rosiodora from the Brazilian Amazon Forest
Chemical and Genotypic Variations in Aniba rosiodora from the Brazilian Amazon Forest Open
Aniba rosiodora has been exploited since the end of the nineteenth century for its essential oil, a valuable ingredient in the perfumery industry. This species occurs mainly in Northern South America, and the morphological similarity among…
View article: Evidence for both phylogenetic conservatism and lability in the evolution of secondary chemistry in a tropical angiosperm radiation
Evidence for both phylogenetic conservatism and lability in the evolution of secondary chemistry in a tropical angiosperm radiation Open
Summary Over evolutionary timescales, shifts in plant secondary chemistry may be associated with patterns of diversification in associated arthropods. Although foundational hypotheses of plant-insect codiversification and plant defense the…
View article: Evaluation of DNA markers for molecular identification of three Piper species from Brazilian Atlantic Rainforest
Evaluation of DNA markers for molecular identification of three Piper species from Brazilian Atlantic Rainforest Open
Piper is one of two large genera in the Piperaceae, and with ca. 2600 species, is one of the largest plant genera in the world. Species delimitation and evaluation of genetic diversity among populations are important requisites for conserv…
View article: Distinct pattern of one-carbon metabolism, a nutrient-sensitive pathway, in invasive breast cancer: A metabolomic study
Distinct pattern of one-carbon metabolism, a nutrient-sensitive pathway, in invasive breast cancer: A metabolomic study Open
Altered cell metabolism is a hallmark of cancer and critical for its development. Particularly, activation of one-carbon metabolism in tumor cells can sustain oncogenesis while contributing to epigenetic changes and metabolic adaptation du…
View article: Editorial: The Ecology of Plant Chemistry and How it Drives Multi-Species Interactions
Editorial: The Ecology of Plant Chemistry and How it Drives Multi-Species Interactions Open
EDITORIAL article Front. Plant Sci., 30 July 2019Sec. Plant Metabolism and Chemodiversity Volume 10 - 2019 | https://doi.org/10.3389/fpls.2019.00967
View article: The role of pericarp in Bidens L. heterocarpy (Asteraceae)
The role of pericarp in Bidens L. heterocarpy (Asteraceae) Open