Lydia Finney
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View article: Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease
Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease Open
The respiratory tract surface is protected from inhaled pathogens by a secreted layer of mucus rich in mucin glycoproteins. Abnormal mucus accumulation is a cardinal feature of chronic respiratory diseases, but the relationship between muc…
View article: Impaired antiviral immunity in frequent exacerbators of chronic obstructive pulmonary disease
Impaired antiviral immunity in frequent exacerbators of chronic obstructive pulmonary disease Open
COPD exacerbations are commonly triggered by viral infections. Some patients with COPD have frequent exacerbations leading to rapid lung function decline and increased mortality. In this study, antiviral responses (interferons) from bronch…
View article: Respiratory Syncytial Virus–related Community Chronic Obstructive Pulmonary Disease Exacerbations and Novel Diagnostics: A Binational Prospective Cohort Study
Respiratory Syncytial Virus–related Community Chronic Obstructive Pulmonary Disease Exacerbations and Novel Diagnostics: A Binational Prospective Cohort Study Open
Rationale: Respiratory syncytial virus (RSV) is a common global respiratory virus that is increasingly recognized as a major pathogen in frail older adults and as a cause of chronic obstructive pulmonary disease (COPD) exacerbations. There…
View article: Accelerated Lung Function Decline and Mucus–Microbe Evolution in Chronic Obstructive Pulmonary Disease
Accelerated Lung Function Decline and Mucus–Microbe Evolution in Chronic Obstructive Pulmonary Disease Open
Rationale: Progressive lung function loss is recognized in chronic obstructive pulmonary disease (COPD); however, no study concurrently evaluates how accelerated lung function decline relates to mucus properties and the microbiome in COPD.…
View article: P202 Clinical characteristics of rhinovirus triggered COPD exacerbations
P202 Clinical characteristics of rhinovirus triggered COPD exacerbations Open
Background Chronic obstructive pulmonary disease (COPD) exacerbations are the main cause of hospital admission and death from COPD. Respiratory viruses are common triggers for COPD exacerbations (AECOPD) with human rhinovirus (RV) being th…
View article: S88 Can coronary artery calcium score calculated from CT thorax be used to predict the presence and severity of coronary artery disease in COPD?
S88 Can coronary artery calcium score calculated from CT thorax be used to predict the presence and severity of coronary artery disease in COPD? Open
Background Coronary artery disease (CAD) is often asymptomatic in patients with chronic obstructive pulmonary disease (COPD) and traditional screening methods may not be as useful in detecting it. A coronary artery calcium score (CACS) can…
View article: Using an electronic diary and wristband accelerometer to detect exacerbations and activity levels in COPD: a feasibility study
Using an electronic diary and wristband accelerometer to detect exacerbations and activity levels in COPD: a feasibility study Open
Background Early and accurate identification of acute exacerbations of COPD may lead to earlier treatment and prevent hospital admission. Electronic diaries have been developed for symptom monitoring and accelerometers to monitor activity.…
View article: A Double-Blind, Randomized, Placebo-controlled Trial of Long-Term Doxycycline Therapy on Exacerbation Rate in Patients with Stable Chronic Obstructive Pulmonary Disease
A Double-Blind, Randomized, Placebo-controlled Trial of Long-Term Doxycycline Therapy on Exacerbation Rate in Patients with Stable Chronic Obstructive Pulmonary Disease Open
Rationale: Chronic obstructive pulmonary disease (COPD) exacerbations are a major cause of morbidity and mortality, and preventing them is a key treatment target. Long-term macrolide treatment is effective at reducing exacerbations, but th…
View article: Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease
Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease Open
The respiratory tract surface is protected from inhaled pathogens by a secreted layer of mucus rich in mucin glycoproteins. Abnormal mucus accumulation is a cardinal feature of chronic respiratory diseases, but the relationship between muc…
View article: Chronic obstructive pulmonary disease in sub-Saharan Africa
Chronic obstructive pulmonary disease in sub-Saharan Africa Open
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and an important cause of death in sub-Saharan Africa (SSA). We conducted a systematic review and meta-analysis on the prevalence of and…
View article: Intra-alveolar neutrophil-derived microvesicles are associated with disease severity in COPD
Intra-alveolar neutrophil-derived microvesicles are associated with disease severity in COPD Open
Despite advances in the pathophysiology of chronic obstructive pulmonary disease (COPD), there is a distinct lack of biochemical markers to aid clinical management. Microvesicles (MVs) have been implicated in the pathophysiology of inflamm…
View article: Repurposing Existing Drugs for the Treatment of COVID-19
Repurposing Existing Drugs for the Treatment of COVID-19 Open
The rapid global spread and significant mortality associated with the coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection has spurred an urgent race to find effective treatm…
View article: Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon Open
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is a new rapidly spreading infectious disease. Early reports of hospitalised COVID-19 cases have shown relatively low frequency of chronic lung diseases such as chronic obstructive p…
View article: Targeted Retreatment of Incompletely Recovered Chronic Obstructive Pulmonary Disease Exacerbations with Ciprofloxacin. A Double-Blind, Randomized, Placebo-controlled, Multicenter, Phase III Clinical Trial
Targeted Retreatment of Incompletely Recovered Chronic Obstructive Pulmonary Disease Exacerbations with Ciprofloxacin. A Double-Blind, Randomized, Placebo-controlled, Multicenter, Phase III Clinical Trial Open
Rationale: Chronic obstructive pulmonary disease (COPD) exacerbations are prone to nonrecovery, but there are no data about the effectiveness of retreatment for these prolonged events. We examined whether further therapy with ciprofloxacin…
View article: Antiviral immunity is impaired in COPD patients with frequent exacerbations
Antiviral immunity is impaired in COPD patients with frequent exacerbations Open
Patients with frequent exacerbations represent a chronic obstructive pulmonary disease (COPD) subgroup requiring better treatment options. The aim of this study was to determine the innate immune mechanisms that underlie susceptibility to …
View article: Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease
Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease Open
Inhaled corticosteroids promote bacterial infection in chronic obstructive pulmonary disease by suppressing the antimicrobial peptide cathelicidin.
View article: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation
MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation Open
The respiratory tract surface is protected from inhaled pathogens by a secreted layer of mucus that is rich in mucin glycoproteins. Disrupted mucus production is a cardinal feature of chronic respiratory diseases but how this alteration af…
View article: Is it safe to prescribe benzodiazepines or opioids for dyspnoea in interstitial lung disease?
Is it safe to prescribe benzodiazepines or opioids for dyspnoea in interstitial lung disease? Open
Low-dose opioids and benzodiazepines are not associated with increased risk of hospitalisation or death in patients with respiratory failure secondary to interstitial lung disease http://ow.ly/SCTl30o9bWq
View article: Anti-microbial immunity is impaired in COPD patients with frequent exacerbations
Anti-microbial immunity is impaired in COPD patients with frequent exacerbations Open
Background Patients with frequent exacerbations represent a chronic obstructive pulmonary disease (COPD) sub-group requiring better treatment options. The aim of this study was to determine the innate immune mechanisms that underlie suscep…
View article: <p>Inflammation and infections in unreported chronic obstructive pulmonary disease exacerbations</p>
Inflammation and infections in unreported chronic obstructive pulmonary disease exacerbations Open
Purpose: COPD patients often do not report acute exacerbations to healthcare providers - unreported exacerbations. It is not known whether variances in symptoms, airway obstruction, aetiology and inflammatory responses account for differen…
View article: Validity of the diagnosis of pneumonia in hospitalised patients with COPD
Validity of the diagnosis of pneumonia in hospitalised patients with COPD Open
Rationale Exacerbations of chronic obstructive pulmonary disease (COPD) and pneumonia are two of the most common reasons for acute hospital admissions. Acute exacerbations and pneumonia present with similar symptoms in COPD patients, repre…
View article: Human Rhinovirus Impairs the Innate Immune Response to Bacteria in Alveolar Macrophages in Chronic Obstructive Pulmonary Disease
Human Rhinovirus Impairs the Innate Immune Response to Bacteria in Alveolar Macrophages in Chronic Obstructive Pulmonary Disease Open
Rationale: Human rhinovirus (HRV) is a common cause of chronic obstructive pulmonary disease (COPD) exacerbations. Secondary bacterial infection is associated with more severe symptoms and delayed recovery. Alveolar macrophages clear bacte…
View article: P56 Human rhinovirus impairs phagocytosis of haemophilus influenzae in alveolar macrophages in chronic obstructive pulmonary disease
P56 Human rhinovirus impairs phagocytosis of haemophilus influenzae in alveolar macrophages in chronic obstructive pulmonary disease Open
Introduction COPD exacerbations are the main cause of hospital admission and death in COPD. Respiratory viruses are identified in over half COPD exacerbations with human rhinovirus (HRV) being the most commonly detected. Secondary bacteria…
View article: T3 Human rhinovirus impairs the innate immune response to bacteria in monocyte derived macrophages from patients with chronic obstructive pulmonary disease
T3 Human rhinovirus impairs the innate immune response to bacteria in monocyte derived macrophages from patients with chronic obstructive pulmonary disease Open
Introduction Exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are associated with accelerated disease progression, hospitalisation and death. Respiratory viruses are identified in approximately half of all exacerbations. We ha…