Lesley A. Jarvis
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View article: Intermediate tissue oxygen level is required to observe murine FLASH skin sparing
Intermediate tissue oxygen level is required to observe murine FLASH skin sparing Open
Purpose: This study evaluated the hypothesis that baseline tissue oxygen (pO2) would modulate FLASH damage sparing in murine skin, comparing MeV ultra-high dose rate (UHDR) versus conventional dose rate (CDR). Methods and Materials: Murine…
View article: Robust real‐time segmentation of bio‐morphological features in human cherenkov imaging during radiotherapy via deep learning
Robust real‐time segmentation of bio‐morphological features in human cherenkov imaging during radiotherapy via deep learning Open
Background Cherenkov imaging enables real‐time visualization of megavoltage X‐ray or electron beam delivery to the patient during radiation therapy (RT). Bio‐morphological features, such as vasculature, seen in these images are patient‐spe…
View article: Achieving selectivity and reduced absorption for low loss monolithic InAs QD based III-V photonic integration
Achieving selectivity and reduced absorption for low loss monolithic InAs QD based III-V photonic integration Open
A straightforward method to achieve monolithic selective area intermixing in an epitaxially grown InAs quantum dot (QD) based laser structure is demonstrated, enabling the development of O-band monolithic photonic integrated circuits. Blue…
View article: Combined Radiation and Endocrine Therapies Elicit Benefit in ER+ Breast Cancer
Combined Radiation and Endocrine Therapies Elicit Benefit in ER+ Breast Cancer Open
Background: Standard treatment for patients with early-stage estrogen receptor-positive (ER+) breast cancer often includes sequential adjuvant radiation and endocrine therapies. Unfortunately, ~1/3 of patients eventually experience disease…
View article: Imaging system for real‐time, full‐field pulse‐by‐pulse surface dosimetry of UHDR electron beams
Imaging system for real‐time, full‐field pulse‐by‐pulse surface dosimetry of UHDR electron beams Open
Background The interest in ultra‐high dose rate (UHDR) radiation therapy (RT) has grown due to its potential to spare normal tissue. However, clinical application is hindered by dosimetry challenges, as current irradiators and dosimeters a…
View article: Cherenkov Imaged Bio-Morphological Features Verify Patient Positioning With Deformable Tissue Translocation in Breast Radiation Therapy
Cherenkov Imaged Bio-Morphological Features Verify Patient Positioning With Deformable Tissue Translocation in Breast Radiation Therapy Open
This study introduces the use of Cherenkov visualized bio-morphological features to quantify the global and local variations in patient positioning based on rigid and nonrigid registrations. This new approach demonstrates the feasibility o…
View article: Major contributors to FLASH sparing efficacy emerge from murine skin studies: dose rate, total dose per fraction, anesthesia and oxygenation
Major contributors to FLASH sparing efficacy emerge from murine skin studies: dose rate, total dose per fraction, anesthesia and oxygenation Open
Background Normal tissue sparing from radiation damage upon ultra-high dose rate irradiation, known as the FLASH effect with an equivalent tumor response, has been widely reported in murine skin models, and translation of this type of radi…
View article: Cherenkov Imaged Bio-morphological Features Verify Patient Positioning with Deformable Tissue Translocation in Breast Radiotherapy
Cherenkov Imaged Bio-morphological Features Verify Patient Positioning with Deformable Tissue Translocation in Breast Radiotherapy Open
Accurate patient positioning is critical for precise radiotherapy dose delivery, as positioning errors can significantly affect treatment outcomes. This study introduces a novel method for tracking loco-regional tissue deformation through …
View article: The impact of breast cancer radiation therapy exposure on the prevalence of breast arterial calcification
The impact of breast cancer radiation therapy exposure on the prevalence of breast arterial calcification Open
Objectives Mammographic breast arterial calcification (BAC) is an emerging imaging biomarker of cardiovascular disease (CVD) risk in women. The purpose of this study was to assess if breast radiation therapy (RT) exposure impacts the scree…
View article: Commissioning an ultra-high-dose-rate electron linac with end-to-end tests
Commissioning an ultra-high-dose-rate electron linac with end-to-end tests Open
Objective . The FLASH effect can potentially be used to improve the therapeutic ratio of radiotherapy (RT) through delivery of Ultra-high-dose-rate (UHDR) irradiation. Research is actively being conducted to translate UHDR-RT and for this …
View article: Electron beam response corrections for an ultra‐high‐dose‐rate capable diode dosimeter
Electron beam response corrections for an ultra‐high‐dose‐rate capable diode dosimeter Open
Background Ultra‐high‐dose‐rate (UHDR) electron beams have been commonly utilized in FLASH studies and the translation of FLASH Radiotherapy (RT) to the clinic. The EDGE diode detector has potential use for UHDR dosimetry albeit with a bea…
View article: First Monte Carlo beam model for ultra‐high dose rate radiotherapy with a compact electron LINAC
First Monte Carlo beam model for ultra‐high dose rate radiotherapy with a compact electron LINAC Open
Background FLASH radiotherapy based on ultra‐high dose rate (UHDR) is actively being studied by the radiotherapy community. Dedicated UHDR electron devices are currently a mainstay for FLASH studies. Purpose To present the first Monte Carl…
View article: Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect
Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect Open
The skin FLASH sparing effect is significantly reduced when using oxygen during anesthesia rather than room air. FLASH sparing was also reduced in female mice compared to male mice. Both tissue oxygenation and sex are likely sources of var…
View article: Anesthetic oxygen use and sex are critical factors in the FLASH sparing effect
Anesthetic oxygen use and sex are critical factors in the FLASH sparing effect Open
Introduction Ultra-high dose-rate (UHDR) radiation has been reported to spare normal tissue compared to conventional dose-rate (CDR) radiation. However, reproducibility of the FLASH effect remains challenging due to varying dose ranges, ra…
View article: Contemporary Applications of Cherenkov Imaging in Radiation Therapy
Contemporary Applications of Cherenkov Imaging in Radiation Therapy Open
Cherenkov radiation (CR) is produced from all high energy radiation sources and is part of the dose delivery process in tissue. As such, CR is a direct indicator of the dose delivery process and in recent years the ability to image and mea…
View article: Comparison of Tumor Control and Skin Damage in a Mouse Model after Ultra-High Dose Rate Irradiation and Conventional Irradiation
Comparison of Tumor Control and Skin Damage in a Mouse Model after Ultra-High Dose Rate Irradiation and Conventional Irradiation Open
Recent studies suggest ultra-high dose rate radiation treatment (UHDR-RT) reduces normal tissue damage compared to conventional radiation treatment (CONV-RT) at the same dose. In this study, we compared first, the kinetics and degree of sk…
View article: Performance comparison of quantitative metrics for analysis of in vivo Cherenkov imaging incident detection during radiotherapy
Performance comparison of quantitative metrics for analysis of in vivo Cherenkov imaging incident detection during radiotherapy Open
Objectives: Examine the responses of multiple image similarity metrics to detect patient positioning errors in radiotherapy observed through Cherenkov imaging, which may be used to optimize automated incident detection. Methods: An anthrop…
View article: Comparing fast imaging techniques for individual pulse imaging by Cherenkov in vivo from electron FLASH irradiation
Comparing fast imaging techniques for individual pulse imaging by Cherenkov in vivo from electron FLASH irradiation Open
Objective: In this study, a fast imaging technique was developed for the first in vivo Cherenkov emission imaging from an ultra-high dose rate (UHDR) electron beam source at single pulse (360 Hz) submillimeter resolution. Approach: A CMOS …
View article: Remote dose imaging from Cherenkov light using spatially resolved CT calibration in breast radiotherapy
Remote dose imaging from Cherenkov light using spatially resolved CT calibration in breast radiotherapy Open
Purpose Imaging Cherenkov light during radiotherapy allows the visualization and recording of frame‐by‐frame relative maps of the dose being delivered to the tissue at each control point used throughout treatment, providing one of the most…
View article: Epidermal growth factor-targeted fluorescence is unaffected by standard neoadjuvant therapies in human sarcoma
Epidermal growth factor-targeted fluorescence is unaffected by standard neoadjuvant therapies in human sarcoma Open
Curative surgery for other many cancers requires that the tumor be removed with a zone of normal tissue surrounding the tumor with 'negative' margins. Sarcomas, cancers of the bones, muscles, and fat, require WLE for cure. Unfortunately, '…
View article: Color Cherenkov imaging of clinical radiation therapy
Color Cherenkov imaging of clinical radiation therapy Open
Color vision is used throughout medicine to interpret the health and status of tissue. Ionizing radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect, and this light is attenuated by …