Lyna Kamintsky YOU? Author Swipe

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An algorithm for seizure detection in rodents Open

Lyna Kamintsky, Gerben van Hameren, Itai Weissberg, Pooyan Moradi, Ofer Prager , et al. · 2025

Objective Epilepsy animal research often relies on long‐term intracranial electroencephalographic (iEEG) recordings. Here, we describe an artificial neural network (ANN) algorithm for automatic detection of seizures. Methods The algorithm …

Imaging blood–brain barrier dysfunction in drug‐resistant epilepsy: A multi‐center feasibility study Open

Alon Friedman, Sheida Mirloo, Daniel Zarhin, Lyna Kamintsky, Yonatan Serlin , et al. · 2024

Objective Blood–brain barrier dysfunction (BBBD) has been linked to various neurological disorders, including epilepsy. This study aims to utilize dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) to identify and compare brain…

Author response: Cortical plasticity is associated with blood–brain barrier modulation Open

Evyatar Swissa, Uri Monsonego, Lynn Yang, Lior Schori, Lyna Kamintsky , et al. · 2024

Cortical plasticity is associated with blood–brain barrier modulation Open

Evyatar Swissa, Uri Monsonego, Lynn Yang, Lior Schori, Lyna Kamintsky , et al. · 2024

Brain microvessels possess the unique properties of a blood–brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…

Author response: Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open

Evyatar Swissa, Uri Monsonego, Lynn Yang, Lior Schori, Lyna Kamintsky , et al. · 2024

Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…

Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open

Evyatar Swissa, Uri Monsonego, Lynn Yang, Lior Schori, Lyna Kamintsky , et al. · 2024

Summary Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the as…

302 Resting state functional connectivity in SLE patients and association with cognitive impairment and blood-brain barrier permeability Open

John G. Hanly, Jason W. Robertson, Alexandra Legge, Lyna Kamintsky, Guillermo Aristi , et al. · 2024

Objective Cognitive impairment (CI) is the most frequent manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE), yet the mechanisms underlying it remain poorly understood. We have previously reported an association between …

Reviewer #3 (Public Review): Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open

Evyatar Swissa, Uri Monsonego, Lynn Yang, Lior Schori, Lyna Kamintsky , et al. · 2024

Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…

Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open

Evyatar Swissa, Uri Monsonego, Lynn Yang, Lior Schori, Lyna Kamintsky , et al. · 2024

Summary Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the as…

Reviewer #1 (Public Review): Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open

Evyatar Swissa, Uri Monsonego, Lynn Yang, Lior Schori, Lyna Kamintsky , et al. · 2024

Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…

Reviewer #2 (Public Review): Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open

Evyatar Swissa, Uri Monsonego, Lynn Yang, Lior Schori, Lyna Kamintsky , et al. · 2024

Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…

Author Response: Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open

Evyatar Swissa, Uri Monsonego, Lynn Yang, Lior Schori, Lyna Kamintsky , et al. · 2024

Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…

Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open

Evyatar Swissa, Uri Monsonego, Lynn Yang, Lior Schori, Lyna Kamintsky , et al. · 2023

Summary Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the as…

Cortical plasticity is associated with blood–brain barrier modulation Open

Evyatar Swissa, Uri Monsonego, Lynn Yang, Lior Schori, Lyna Kamintsky , et al. · 2023

Brain microvessels possess the unique properties of a blood–brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…

Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open

Evyatar Swissa, Uri Monsonego, Lynn Yang, Lior Schori, Lyna Kamintsky , et al. · 2023

Summary Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the as…

Resting state functional connectivity in SLE patients and association with cognitive impairment and blood–brain barrier permeability Open

John G. Hanly, Jason W. Robertson, Alexandra Legge, Lyna Kamintsky, Guillermo Aristi , et al. · 2022

Objective Extensive blood–brain barrier (BBB) leakage has been linked to cognitive impairment in SLE. This study aimed to examine the associations of brain functional connectivity (FC) with cognitive impairment and BBB dysfunction among pa…

Role of autoantibodies and blood–brain barrier leakage in cognitive impairment in systemic lupus erythematosus Open

John G. Hanly, Alexandra Legge, Lyna Kamintsky, Alon Friedman, Javeria A. Hashmi , et al. · 2022

Objective Cognitive impairment is common in patients with SLE but the cause is unknown. The current cross-sectional study examined the association between select SLE-related autoantibodies, other serological biomarkers and extensive blood–…

Symptoms reported by Canadians posted in Havana are linked with reduced white matter fibre density Open

Guillermo Aristi, Lyna Kamintsky, Margaux Ross, Chris V. Bowen, Cynthia Calkin , et al. · 2022

Diplomats representing the USA have reported with unusual neurologic symptoms and MRI changes after being posted in Havana, Cuba between late 2016 and 2018. Here, we examined white matter microstructure and network connectivity of individu…

Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction Open

Ellen Parker, Refat Aboghazleh, Griffin Mumby, Ronel Veksler, Jonathan Ofer , et al. · 2021

The mechanisms underlying the complications of mild traumatic brain injury, including post-concussion syndrome, post-impact catastrophic death, and delayed neurodegeneration remain poorly understood. This limited pathophysiological underst…

P.185 Impact-detecting helmets as indicators of concussion and blood brain barrier integrity in university football players Open

Cheryl Jones, Lorelei Audas, Nelofar Kureshi, Lyna Kamintsky, Lynne Fenerty , et al. · 2021

Background: Repetitive sub-concussive head impacts have been associated with changes in brain architecture and neurological symptoms. In this study, we examined the association between repetitive sub-concussive impacts, impact burden, and …

Insulin Resistance and Blood-Brain Barrier Dysfunction Underlie Neuroprogression in Bipolar Disorder Open

Cynthia Calkin, Christie McClelland, Kathleen Cairns, Lyna Kamintsky, Alon Friedman · 2021

Bipolar disorder (BD) often progresses to a more chronic and treatment resistant (neuroprogressive) course. Identifying which patients are at risk could allow for early intervention and prevention. Bipolar disorder is highly comorbid with …

Response to: ‘Correspondence on ‘Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment’’ by Pamuk and Hasni Open

Lyna Kamintsky, Steven Beyea, John D. Fisk, Javeria A. Hashmi, Antonina Omisade , et al. · 2021

The potential role of microvascular pathology in the neurological manifestations of coronavirus infection Open

Mark A. MacLean, Lyna Kamintsky, Erika Leck, Alon Friedman · 2020

Human coronaviruses are highly pathogenic viruses that pose a serious threat to human health. Examples include the severe acute respiratory syndrome outbreak of 2003 (SARS-CoV-1), the Middle East Respiratory Syndrome (MERS-CoV) outbreak of…

Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players Open

Ronel Veksler, Udi Vazana, Yonatan Serlin, Ofer Prager, Jonathan Ofer , et al. · 2020

Repetitive mild traumatic brain injury in American football players has garnered increasing public attention following reports of chronic traumatic encephalopathy, a progressive tauopathy. While the mechanisms underlying repetitive mild tr…

Blood-brain barrier imaging as a potential biomarker for bipolar disorder progression Open

Lyna Kamintsky, Kathleen Cairns, Ronel Veksler, Chris V. Bowen, Steven Beyea , et al. · 2019

Bipolar disorder affects approximately 2% of the population and is typically characterized by recurrent episodes of mania and depression. While some patients achieve remission using mood-stabilizing treatments, a significant proportion of …

Havana Syndrome Among Canadian Diplomats: Brain Imaging Reveals Acquired Neurotoxicity Open

Alon Friedman, Cynthia Calkin, Amanda Adams, Guillermo Aristi Suarez, Tim Bardouille , et al. · 2019

BACKGROUND In late 2016, US diplomats stationed in Havana began presenting with a variety of neurological manifestations that proved difficult to diagnose. Though previous studies suggested a likely association with brain injury, the mecha…

Seizure‐induced microvascular injury is associated with impaired neurovascular coupling and blood–brain barrier dysfunction Open

Ofer Prager, Lyna Kamintsky, Luisa A. Hasam‐Henderson, Karl Schoknecht, Vera Wuntke , et al. · 2019

Summary Objective Blood–brain barrier ( BBB ) impairment, redistribution of pericytes, and disturbances in cerebral blood flow may contribute to the increased seizure propensity and neurological comorbidities associated with epilepsy. Howe…

Electrocorticographic Dynamics as a Novel Biomarker in Five Models of Epileptogenesis Open

Dan Z. Milikovsky, Itai Weissberg, Lyna Kamintsky, Kristina Lippmann, Osnat Schefenbauer , et al. · 2017

Postinjury epilepsy (PIE) is a devastating sequela of various brain insults. While recent studies offer novel insights into the mechanisms underlying epileptogenesis and discover potential preventive treatments, the lack of PIE biomarkers …

Imaging blood–brain barrier dysfunction as a biomarker for epileptogenesis Open

Guy Bar‐Klein, Svetlana Lublinsky, Lyna Kamintsky, Iris Noyman, Ronel Veksler , et al. · 2017

A biomarker that will enable the identification of patients at high-risk for developing post-injury epilepsy is critically required. Microvascular pathology and related blood-brain barrier dysfunction and neuroinflammation were shown to be…

Epileptiform activity and spreading depolarization in the blood–brain barrier-disrupted peri-infarct hippocampus are associated with impaired GABAergic inhibition and synaptic plasticity Open

Kristina Lippmann, Lyna Kamintsky, Soo Young Kim, Svetlana Lublinsky, Ofer Prager , et al. · 2016

Peri-infarct opening of the blood–brain barrier may be associated with spreading depolarizations, seizures, and epileptogenesis as well as cognitive dysfunction. We aimed to investigate the mechanisms underlying neural network pathophysiol…

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