Lynda Constable
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View article: Protocol for a feasibility randomized control trial of the Supporting Toddlers with a connection to autism or ADHD to develop Strong Attention, Regulation, and Thinking skills (START) programme
Protocol for a feasibility randomized control trial of the Supporting Toddlers with a connection to autism or ADHD to develop Strong Attention, Regulation, and Thinking skills (START) programme Open
View article: Patient and healthcare professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: qualitative study of the CATHETER II trial
Patient and healthcare professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: qualitative study of the CATHETER II trial Open
Objectives To explore trial participants’ experience of long-term catheters (LTC), the acceptability of washout policies, their experience of the CATHETER II trial (a randomised controlled trial comparing the clinical effectiveness of vari…
View article: 320 - Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial
320 - Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial Open
View article: 260 - CATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters
260 - CATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters Open
View article: User Experiences in a Digital Intervention to Support Total Skin Self-examination by Melanoma Survivors: Nested Qualitative Evaluation Embedded in a Randomized Controlled Trial
User Experiences in a Digital Intervention to Support Total Skin Self-examination by Melanoma Survivors: Nested Qualitative Evaluation Embedded in a Randomized Controlled Trial Open
Background Melanoma is a relatively common cancer type with a high survival rate, but survivors risk recurrences or second primaries. Consequently, patients receive regular hospital follow-up, but this can be burdensome to attend and not o…
View article: Randomised Controlled Trial CompAring THE Clinical And CosT-Effectiveness Of VaRious Washout Policies Versus No Washout Policy In Preventing Catheter Associated Complications In Adults Living With Long-Term Catheters: study protocol for the CATHETER II study.
Randomised Controlled Trial CompAring THE Clinical And CosT-Effectiveness Of VaRious Washout Policies Versus No Washout Policy In Preventing Catheter Associated Complications In Adults Living With Long-Term Catheters: study protocol for the CATHETER II study. Open
View article: The Achieving Self-directed Integrated Cancer Aftercare Intervention for Detection of Recurrent and Second Primary Melanoma in Survivors of Melanoma: Pilot Randomized Controlled Trial
The Achieving Self-directed Integrated Cancer Aftercare Intervention for Detection of Recurrent and Second Primary Melanoma in Survivors of Melanoma: Pilot Randomized Controlled Trial Open
Background Melanoma is common with increasing incidence. Guidelines recommend monthly total skin self-examinations (TSSEs) by survivors to detect recurrent and new primary melanomas. TSSE is underperformed despite evidence of benefit. Obje…
View article: User Experiences in a Digital Intervention to Support Total Skin Self-examination by Melanoma Survivors: Nested Qualitative Evaluation Embedded in a Randomized Controlled Trial (Preprint)
User Experiences in a Digital Intervention to Support Total Skin Self-examination by Melanoma Survivors: Nested Qualitative Evaluation Embedded in a Randomized Controlled Trial (Preprint) Open
BACKGROUND Melanoma is a relatively common cancer type with a high survival rate, but survivors risk recurrences or second primaries. Consequently, patients receive regular hospital follow-up, but this can be burdensome to attend and not …
View article: The Achieving Self-Directed Integrated Cancer Aftercare (ASICA) intervention for detection of recurrent and second primary melanoma: a randomized pilot trial (Preprint)
The Achieving Self-Directed Integrated Cancer Aftercare (ASICA) intervention for detection of recurrent and second primary melanoma: a randomized pilot trial (Preprint) Open
BACKGROUND Melanoma is common and incidence increasing. Guidelines recommend monthly Total-Skin-Self-Examination (TSSE) performed by melanoma survivors to detect recurrent and new primary melanoma. TSSE is underperformed despite evidence …
View article: Male synthetic sling or artificial urinary sphincter (AUS) for men with urodynamic stress incontinenceafter prostate surgery: the MASTER non-inferiority randomised controlled trial
Male synthetic sling or artificial urinary sphincter (AUS) for men with urodynamic stress incontinenceafter prostate surgery: the MASTER non-inferiority randomised controlled trial Open
View article: A Nested Qualitative Evaluation of User Experiences in a Randomized Trial of a Digital Intervention To Support Total-Skin-Self-Examination By Melanoma Survivors
A Nested Qualitative Evaluation of User Experiences in a Randomized Trial of a Digital Intervention To Support Total-Skin-Self-Examination By Melanoma Survivors Open
Background Melanoma is a common cancer with a high survival rate, as well as a high chance of recurrence. Combined, this leads to a high burden of follow-up. Total-Skin-Self-Examination (TSSE) improves clinical outcomes of melanoma via ear…
View article: Outcomes of a Noninferiority Randomised Controlled Trial of Surgery for Men with Urodynamic Stress Incontinence After Prostate Surgery (MASTER)
Outcomes of a Noninferiority Randomised Controlled Trial of Surgery for Men with Urodynamic Stress Incontinence After Prostate Surgery (MASTER) Open
View article: A Randomised Patient-Focused Trial of the Achieving Self-Directed Integrated Cancer Aftercare (ASICA) Intervention for Detection of Recurrent and Second Primary Melanoma: Effect on Psychological Well-Being and Quality of Life
A Randomised Patient-Focused Trial of the Achieving Self-Directed Integrated Cancer Aftercare (ASICA) Intervention for Detection of Recurrent and Second Primary Melanoma: Effect on Psychological Well-Being and Quality of Life Open
View article: It is unprecedented: trial management during the COVID-19 pandemic and beyond
It is unprecedented: trial management during the COVID-19 pandemic and beyond Open
The COVID-19 pandemic has presented unique challenges for the clinical trial community, both in the rapid establishment of COVID-19 clinical trials and many existing non-COVID-19 studies either being temporarily paused (whether that is a c…
View article: How to deal with a temporary suspension and restarting your trial: our experiences and lessons learnt
How to deal with a temporary suspension and restarting your trial: our experiences and lessons learnt Open
Whilst the issues around early termination of randomised controlled trials (RCTs) are well documented in the literature, trials can also be temporarily suspended with the real prospect that they may subsequently restart. There is little gu…
View article: Using systematic data categorisation to quantify the types of data collected in clinical trials: the DataCat project
Using systematic data categorisation to quantify the types of data collected in clinical trials: the DataCat project Open
View article: Verifying participant-reported clinical outcomes: challenges and implications
Verifying participant-reported clinical outcomes: challenges and implications Open
Background Researchers often rely on trial participants to self-report clinical outcomes (for example, fractures, re-operations). Little information exists as to the ‘accuracy’ of participant-reported clinical outcomes, particularly in ran…
View article: Verifying participant reported clinical outcomes: challenges and implications
Verifying participant reported clinical outcomes: challenges and implications Open
Background Researchers often rely on trial participants to self-report clinical outcomes (for example fracture, re-operation). Little information exists as to the “accuracy” of participant reported clinical outcomes, particularly in random…
View article: Verifying participant reported clinical outcomes: challenges and implications
Verifying participant reported clinical outcomes: challenges and implications Open
Background Researchers often rely on trial participants to self-report clinical outcomes (for example fracture, re-operation). Little information exists as to the “accuracy” of participant reported clinical outcomes, particularly in random…
View article: Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells
Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells Open
View article: The importance of rapport and relationship building when recruiting to clinical trials: a qualitative investigation of trial recruitment consultations in a surgical RCT
The importance of rapport and relationship building when recruiting to clinical trials: a qualitative investigation of trial recruitment consultations in a surgical RCT Open
Results The key findings highlighted the importance of; a) the context to the recruitment consultation, b) the current health status of potential participants at the time of trial invitation, and c) the trial information exchange process. …
View article: Overcoming a trial ‘adverse event’: impact and experiences of a temporary suspension of randomisation in clinical trials
Overcoming a trial ‘adverse event’: impact and experiences of a temporary suspension of randomisation in clinical trials Open
A number of factors can result in the temporary suspension of randomisation in clinical trials, with the most common being safety, effectiveness and recruitment. However, external factors such as commercial, political, patient and media pr…