Lyndi L. Gilliam
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View article: Pharmacokinetics of Chloramphenicol and Chloramphenicol Glucuronide in Horses Following Administration Per Rectum or via Nasogastric Intubation
Pharmacokinetics of Chloramphenicol and Chloramphenicol Glucuronide in Horses Following Administration Per Rectum or via Nasogastric Intubation Open
Chloramphenicol is a broad‐spectrum antibiotic used in equine practice. It is known to produce adverse effects of hyporexia/anorexia after oral administration. Administration per rectum (PR) could mitigate the appetite suppression seen wit…
View article: Pharmacokinetics of amikacin after intravenous, intra‐articular, and combined intravenous and intra‐articular administration in healthy neonatal foals
Pharmacokinetics of amikacin after intravenous, intra‐articular, and combined intravenous and intra‐articular administration in healthy neonatal foals Open
Background Pharmacokinetics of amikacin administered IV to neonatal foals are described, but little data are available regarding the plasma concentrations contributed by concurrent intra‐articular (IA) administration. Hypothesis/Objectives…
View article: Oral and IV Varespladib Rescue Experiments in Juvenile Pigs with Weakness Induced by Australian and Papuan Oxyuranus scutellatus Venoms
Oral and IV Varespladib Rescue Experiments in Juvenile Pigs with Weakness Induced by Australian and Papuan Oxyuranus scutellatus Venoms Open
Antivenom is currently the standard-of-care treatment for snakebite envenoming, but its efficacy is limited by treatment delays, availability, and in many cases, species specificity. Many of the rapidly lethal effects of envenoming are cau…
View article: Nebulized glycosylated caffeic acid phenylether ester attenuation of environmental particulate-induced airway inflammation in horses
Nebulized glycosylated caffeic acid phenylether ester attenuation of environmental particulate-induced airway inflammation in horses Open
The objective of this study was to determine the extent that nebulized glycosylated caffeic acid phenylether ester-4-O-alpha-D-glucopyranoside (G-CAPE) attenuates particulate-induced airway inflammation in healthy horses. Our hypothesis wa…
View article: Thromboelastography in obese horses with insulin dysregulation compared to healthy controls
Thromboelastography in obese horses with insulin dysregulation compared to healthy controls Open
Background Both obesity and metabolic syndrome are associated with hypercoagulability in people, increasing the risk of cardiovascular disease and thromboembolic events. Whether hypercoagulability exists in obese, insulin‐dysregulated hors…
View article: Characterization of short‐ and long‐term morbidity and mortality of goat kids born to does with pregnancy toxemia
Characterization of short‐ and long‐term morbidity and mortality of goat kids born to does with pregnancy toxemia Open
Background Pregnancy toxemia is a common metabolic disease of periparturient small ruminants. Information on its effects on metabolism and perinatal adaptation of newborn lambs and kids is lacking. Objectives Evaluate differences in morbid…
View article: Foal Amikacin Final Results 2.25.2019a.xlsx
Foal Amikacin Final Results 2.25.2019a.xlsx Open
Six healthy neonatal foals (4 Quarter Horses & 2 Paint horses; 5 colts & 1 filly; mean ± SD weight at 7 days of age at start of study, 59.7 ± 8.0 kg; weight at 24 days of age at end of last protocol 85.2 ± 11.9 kg) completed three amikacin…
View article: Foal Amikacin Final Results 2.25.2019a.xlsx
Foal Amikacin Final Results 2.25.2019a.xlsx Open
Six healthy neonatal foals (4 Quarter Horses & 2 Paint horses; 5 colts & 1 filly; mean ± SD weight at 7 days of age at start of study, 59.7 ± 8.0 kg; weight at 24 days of age at end of last protocol 85.2 ± 11.9 kg) completed three amikacin…
View article: Foal Amikacin Final Results 2.25.2019a.xlsx
Foal Amikacin Final Results 2.25.2019a.xlsx Open
Six healthy neonatal foals (4 Quarter Horses & 2 Paint horses; 5 colts & 1 filly; mean ± SD weight at 7 days of age at start of study, 59.7 ± 8.0 kg; weight at 24 days of age at end of last protocol 85.2 ± 11.9 kg) completed three amikacin…
View article: Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral Snake) Venom
Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral Snake) Venom Open
There is a clear, unmet need for effective, lightweight, shelf-stable and economical snakebite envenoming therapies that can be given rapidly after the time of a snake’s bite and as adjuncts to antivenom therapies in the hospital setting. …
View article: Efficacy of the early administration of valacyclovir hydrochloride for the treatment of neuropathogenic equine herpesvirus type-1 infection in horses
Efficacy of the early administration of valacyclovir hydrochloride for the treatment of neuropathogenic equine herpesvirus type-1 infection in horses Open
OBJECTIVE To determine whether prophylactic administration of valacyclovir hydrochloride versus initiation of treatment at the onset of fever would differentially protect horses from viral replication and clinical disease attributable to e…
View article: <i>Lathyrus hirsutus</i> (Caley Pea) Intoxication in a Herd of Horses
<i>Lathyrus hirsutus</i> (Caley Pea) Intoxication in a Herd of Horses Open
Background Caley Pea ( Lathyrus hirsutus ) is potentially toxic to horses, but large case series are not reported. Objectives To describe the clinical signs of horses intoxicated with Lathyrus hirsutus and speculate on the neuroanatomical …