Lyndsay A. Harshman
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View article: Systematic review of neuroimaging findings in children and young adults with chronic kidney disease
Systematic review of neuroimaging findings in children and young adults with chronic kidney disease Open
Background Chronic kidney disease (CKD) is associated with poorer neurocognitive outcomes. Neuroimaging studies have been mostly undertaken in older adults. However, individuals under 25 are uniquely impacted due to concurrent brain develo…
View article: Stealing nephrons—a review on how patent ductus arteriosus physiology impacts neonatal kidney health
Stealing nephrons—a review on how patent ductus arteriosus physiology impacts neonatal kidney health Open
Adverse short- and long-term kidney outcomes are increasingly recognized as sequelae of NICU care, oftentimes of multifactorial origin and in the setting of a patent ductus arteriosus (PDA). Many studies have reviewed the interactions betw…
View article: COVID-19 Associated Worry and Emotional Distress in Youth and Young Adults with Chronic Kidney Disease
COVID-19 Associated Worry and Emotional Distress in Youth and Young Adults with Chronic Kidney Disease Open
The COVID-19 (C19) pandemic impacted youth mental/behavioral health with a 25% increase in prevalence of anxiety and depression worldwide. Little is known about the emotional impact of C19 for children with Chronic Kidney Disease (CKD).
View article: Assessment and management of magnesium and trace element status in children with CKD stages 2–5, on dialysis and post-transplantation: Clinical practice points from the Pediatric Renal Nutrition Taskforce
Assessment and management of magnesium and trace element status in children with CKD stages 2–5, on dialysis and post-transplantation: Clinical practice points from the Pediatric Renal Nutrition Taskforce Open
Children and young people with chronic kidney disease (CKD) are at risk for deficiency or excess of magnesium and trace elements. Kidney function, dialysis, medication, and dietary and supplemental intake can affect their biochemical statu…
View article: Iliocaval Anomaly With Resulting Congestive Nephropathy: A Rare Etiology of Allograft Dysfunction Following Kidney Transplantation
Iliocaval Anomaly With Resulting Congestive Nephropathy: A Rare Etiology of Allograft Dysfunction Following Kidney Transplantation Open
Background Renal allograft dysfunction warrants prompt investigation as the differential diagnosis is often broad. Here, we present a pediatric kidney transplant recipient who experienced suboptimal allograft function due to previously und…
View article: Kidney Function Following COVID-19 in Children and Adolescents
Kidney Function Following COVID-19 in Children and Adolescents Open
Importance It remains unclear whether children and adolescents with SARS-CoV-2 infection are at heightened risk for long-term kidney complications. Objective To investigate whether SARS-CoV-2 infection is associated with an increased risk …
View article: Age-Related Changes in Brain Structure in Pediatric Chronic Kidney Disease
Age-Related Changes in Brain Structure in Pediatric Chronic Kidney Disease Open
Importance Pediatric patients with chronic kidney disease (CKD) exhibit reduced cerebellum volume, which is associated with neurocognitive deficits and a lower estimated glomerular filtration rate (eGFR), even before dialysis or transplant…
View article: β-Blocker Use and Delayed Onset and Progression of Huntington Disease
β-Blocker Use and Delayed Onset and Progression of Huntington Disease Open
Importance Huntington disease (HD) is characterized by motor, cognitive, and psychiatric decline. β-Blockers may play a therapeutic role by decreasing enhanced sympathetic tone in HD. Objective To evaluate the impact of β-blockers on the t…
View article: An Improved Postprocessing Method to Mitigate the Macroscopic Cross-Slice B0 Field Effect on R2* Measurements in the Mouse Brain at 7T
An Improved Postprocessing Method to Mitigate the Macroscopic Cross-Slice B0 Field Effect on R2* Measurements in the Mouse Brain at 7T Open
The MR transverse relaxation rate, R2*, has been widely used to detect iron and myelin content in tissue. However, it is also sensitive to macroscopic B0 inhomogeneities. One approach to correct for the B0 effect is to fit gradient-echo si…
View article: Nutritional management of the child with chronic kidney disease and on dialysis
Nutritional management of the child with chronic kidney disease and on dialysis Open
While it is widely accepted that the nutritional management of the infant with chronic kidney disease (CKD) is paramount to achieve normal growth and development, nutritional management is also of importance beyond 1 year of age, particula…
View article: Post-acute and Chronic Kidney Function Outcomes of COVID-19 in Children and Adolescents: An EHR Cohort Study from the RECOVER Initiative
Post-acute and Chronic Kidney Function Outcomes of COVID-19 in Children and Adolescents: An EHR Cohort Study from the RECOVER Initiative Open
We investigated the risks of post-acute and chronic adverse kidney outcomes of SARS-CoV-2 infection in the pediatric population via a retrospective cohort study using data from the RECOVER program. We included 1,864,637 children and adoles…
View article: Kidney transplantation in patients with tuberous sclerosis complex
Kidney transplantation in patients with tuberous sclerosis complex Open
Background Tuberous sclerosis complex (TSC) is a disorder of the mammalian target of the rapamycin (mTOR) pathway associated with the development of multisystem tumors, including renal angiomyolipoma (AML). These renal tumors are benign by…
View article: Psychotropic Medication Usage in Pediatric CKD: Reporting from the CKD in Children Cohort
Psychotropic Medication Usage in Pediatric CKD: Reporting from the CKD in Children Cohort Open
Key Points Psychotropic medication use is prevalent in the pediatric CKD population. Central nervous system stimulant usage was more common in male patients, and antidepressant usage was more frequently reported at follow-up visits during …
View article: Adult and late adolescent complications of pediatric solid organ transplantation
Adult and late adolescent complications of pediatric solid organ transplantation Open
Background There have been over 51 000 pediatric solid organ transplants since 1988 in the United States alone, leading to a growing population of long‐term survivors who face complications of childhood organ failure and long‐term immunosu…
View article: Antibody‐mediated rejection in pediatric kidney transplant recipients: A report from the Pediatric Nephrology Research Consortium
Antibody‐mediated rejection in pediatric kidney transplant recipients: A report from the Pediatric Nephrology Research Consortium Open
Background Antibody‐mediated rejection (AMR) is a major cause of kidney allograft loss. There is a paucity of large‐scale pediatric‐specific data regarding AMR treatment outcomes. Methods Data were obtained from 14 centers within the Pedia…
View article: Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol
Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol Open
Objective Evaluate the impact of a sodium (Na) supplementation protocol based upon urine Na concentration on growth parameters and morbidities. Study Design Retrospective cohort study of infants 260/7-336/7 weeks gestational age (GA) cared…
View article: Prevalence of mycophenolate mofetil discontinuation and subsequent outcomes in pediatric kidney transplant recipients: A PNRC study
Prevalence of mycophenolate mofetil discontinuation and subsequent outcomes in pediatric kidney transplant recipients: A PNRC study Open
Background Mycophenolate Mofetil (MMF) is an effective immunosuppressant used in kidney transplant recipients to prevent acute rejection. Complications such as diarrhea, leukopenia, and infections may necessitate the reduction or discontin…
View article: Understanding the impact of pediatric kidney transplantation on cognition: A review of the literature
Understanding the impact of pediatric kidney transplantation on cognition: A review of the literature Open
Background Chronic kidney disease (CKD) is a relatively rare childhood disease that is associated with a wide array of medical comorbidities. Roughly half of all pediatric patients acquire CKD due to congenital anomalies of the kidneys and…
View article: The Impact of Pediatric CKD on Educational and Employment Outcomes
The Impact of Pediatric CKD on Educational and Employment Outcomes Open
Key Points This study evaluates educational and employment outcomes in patients with pediatric kidney disease and assesses predictors of educational attainment and employment in young adulthood. Despite high rates of high school graduation…