Lynette J. Oost
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View article: Cancer incidence and diagnostic characteristics in people with intellectual disabilities in the Netherlands: a national registry-based cohort study
Cancer incidence and diagnostic characteristics in people with intellectual disabilities in the Netherlands: a national registry-based cohort study Open
Objective People with intellectual disabilities (ID) face notable health disparities, also affecting cancer care. This study is among the first to use nationwide population and cancer registry databases to compare cancer incidence in the p…
View article: Proton pump inhibitor induced hypomagnesemia and mortality: mediation analyses in the Diabetes Care System cohort
Proton pump inhibitor induced hypomagnesemia and mortality: mediation analyses in the Diabetes Care System cohort Open
Background: Chronic proton pump inhibitor (PPI) use and hypomagnesemia are common in people with type 2 diabetes (T2D), and both are associated with increased mortality and cardiovascular disease (CVD). Since PPI use can cause hypomagnesem…
View article: Hypomagnesemia and Cardiovascular Risk in Type 2 Diabetes
Hypomagnesemia and Cardiovascular Risk in Type 2 Diabetes Open
Hypomagnesemia is 10-fold more common in individuals with type 2 diabetes (T2D) than in the healthy population. Factors that are involved in this high prevalence are low Mg2+ intake, gut microbiome composition, medication use, and presumab…
View article: Magnesium increases insulin-dependent glucose uptake in adipocytes
Magnesium increases insulin-dependent glucose uptake in adipocytes Open
Background Type 2 diabetes (T2D) is characterized by a decreased insulin sensitivity. Magnesium (Mg 2+ ) deficiency is common in people with T2D. However, the molecular consequences of low Mg 2+ levels on insulin sensitivity and glucose ha…
View article: Serum Magnesium Is Inversely Associated With Heart Failure, Atrial Fibrillation, and Microvascular Complications in Type 2 Diabetes
Serum Magnesium Is Inversely Associated With Heart Failure, Atrial Fibrillation, and Microvascular Complications in Type 2 Diabetes Open
Objective We investigated whether serum magnesium (Mg2+) was prospectively associated with macro- or microvascular complications and mediated by glycemic control (Hemoglobin A1c (HbA1c)), in T2D. Research Design and Methods We analyzed i…
View article: Serum Magnesium Is Inversely Associated With Heart Failure, Atrial Fibrillation, and Microvascular Complications in Type 2 Diabetes
Serum Magnesium Is Inversely Associated With Heart Failure, Atrial Fibrillation, and Microvascular Complications in Type 2 Diabetes Open
OBJECTIVE We investigated whether serum magnesium (Mg2+) was prospectively associated with macro- or microvascular complications and mediated by glycemic control (hemoglobin A1c [HbA1c]), in type 2 diabetes (T2D). RESEARCH DESIGN AND METHO…
View article: Serum Magnesium Is Inversely Associated With Heart Failure, Atrial Fibrillation, and Microvascular Complications in Type 2 Diabetes
Serum Magnesium Is Inversely Associated With Heart Failure, Atrial Fibrillation, and Microvascular Complications in Type 2 Diabetes Open
Objective We investigated whether serum magnesium (Mg2+) was prospectively associated with macro- or microvascular complications and mediated by glycemic control (Hemoglobin A1c (HbA1c)), in T2D. Research Design and Methods We analyzed i…
View article: The authors reply: Letter on: “Fibroblast growth factor 21 controls mitophagy and muscle mass” by Oost et al.
The authors reply: Letter on: “Fibroblast growth factor 21 controls mitophagy and muscle mass” by Oost et al. Open
No abstract available
View article: Fibroblast growth factor 21 controls mitophagy and muscle mass
Fibroblast growth factor 21 controls mitophagy and muscle mass Open
Background Skeletal muscle is a plastic tissue that adapts to changes in exercise, nutrition, and stress by secreting myokines and myometabolites. These muscle‐secreted factors have autocrine, paracrine, and endocrine effects, contributing…