Lynette J. Tippett
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View article: On the structural and practical identifiability of multi‐echo BBB‐ASL tracer kinetic models
On the structural and practical identifiability of multi‐echo BBB‐ASL tracer kinetic models Open
Purpose Tracer kinetic models are used in arterial spin labeling (ASL); however, deciding which model parameters to fix or fit is not always trivial. The identifiability of the resultant system of equations is useful to consider, since it …
View article: Neurodegenerative Diseases in Male Former First-Class New Zealand Rugby Players
Neurodegenerative Diseases in Male Former First-Class New Zealand Rugby Players Open
Background Growing concern surrounds the risk of neurodegenerative diseases in high-level collision sports, but research on Rugby Union's connection to these diseases is limited. Objective This study sought to examine the long-term neurode…
View article: Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington’s disease human cerebral cortex
Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington’s disease human cerebral cortex Open
Huntington's disease (HD) is a hereditary neurodegenerative condition caused by a CAG repeat expansion mutation in the gene encoding the huntingtin (HTT) protein. The accumulation of HTT inclusion bodies is a pathological hallmark of HD an…
View article: Prevalence of Dementia in European, Chinese and Indian/Fijian‐Indian Populations in Aotearoa New Zealand: A Protocol
Prevalence of Dementia in European, Chinese and Indian/Fijian‐Indian Populations in Aotearoa New Zealand: A Protocol Open
Objectives Aotearoa New Zealand (NZ) is a bicultural nation (Māori and European) with a growing population of Asian and Pacific peoples. Recent analysis of national routinely collected data suggests dementia prevalence is higher in Māori a…
View article: Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5
Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5 Open
MicroRNAs (miRNAs) are small non-coding RNAs that play crucial roles in post-transcriptional gene regulation. Poly(A) RNA polymerase D5 (PAPD5) catalyzes the addition of adenosine to the 3′ end of miRNAs. In this study, we demonstrate that…
View article: Elucidating cortical neurovascular involvement in Huntington's disease using human brain tissue microarrays
Elucidating cortical neurovascular involvement in Huntington's disease using human brain tissue microarrays Open
Although the genetic basis of Huntington's disease (HD) has been determined, the underlying pathophysiological mechanisms contributing to neurodegeneration remain largely unknown. In recent years, increasing evidence has posited vascular d…
View article: Midlife physical activity and amnestic MCI: Impact on hippocampal volume
Midlife physical activity and amnestic MCI: Impact on hippocampal volume Open
Background The projected doubling of dementia prevalence by 2050 highlights the critical importance of altering the dementia trajectory and associated burden. Modifiable risk factors account for 40% of dementia risk (Livingston et al, 2020…
View article: The New Zealand‐Dementia Prevention Research Clinics: Plasma biomarkers and the Alzheimer’s disease continuum
The New Zealand‐Dementia Prevention Research Clinics: Plasma biomarkers and the Alzheimer’s disease continuum Open
Background Single molecule array (Simoa) technology enables the detection of Alzheimer’s disease (AD) neuropathology in blood. This study compared cross‐sectional biomarker profiles for participants from the New Zealand‐Dementia Prevention…
View article: Investigation of structural connectivity in the whole brain and frontoparietal network in groups at risk of Alzheimer’s disease dementia
Investigation of structural connectivity in the whole brain and frontoparietal network in groups at risk of Alzheimer’s disease dementia Open
Background Brain connectivity patterns, measured with Magnetic Resonance Imaging (MRI), have been recently studied as a potential biomarker for Alzheimer’s disease dementia (AD). A ‘disconnected brain’ has been associated with greater cogn…
View article: Measurement of blood–brain barrier water exchange rate using diffusion‐prepared and multi‐echo arterial spin labelling: Comparison of quantitative values and age dependence
Measurement of blood–brain barrier water exchange rate using diffusion‐prepared and multi‐echo arterial spin labelling: Comparison of quantitative values and age dependence Open
Water exchange rate (Kw) across the blood–brain barrier (BBB) is an important physiological parameter that may provide new insight into ageing and neurodegenerative disease. Recently, two non‐invasive arterial spin labelling (ASL) MRI meth…
View article: Huntingtin is an RNA binding protein and participates in <i>NEAT1</i> -mediated paraspeckles
Huntingtin is an RNA binding protein and participates in <i>NEAT1</i> -mediated paraspeckles Open
Huntingtin protein, mutated in Huntington’s disease, is implicated in nucleic acid–mediated processes, yet the evidence for direct huntingtin–nucleic acid interaction is limited. Here, we show wild-type and mutant huntingtin copurify with …
View article: Microglial proliferation and astrocytic protein alterations in the human Huntington's disease cortex
Microglial proliferation and astrocytic protein alterations in the human Huntington's disease cortex Open
Huntington's disease (HD) is a neurodegenerative disorder that severely affects the basal ganglia and regions of the cerebral cortex. While astrocytosis and microgliosis both contribute to basal ganglia pathology, the contribution of glios…
View article: Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer’s disease (DEBBIE-AD): a prospective observational multicohort study protocol
Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer’s disease (DEBBIE-AD): a prospective observational multicohort study protocol Open
Introduction Loss of blood-brain barrier (BBB) integrity is hypothesised to be one of the earliest microvascular signs of Alzheimer’s disease (AD). Existing BBB integrity imaging methods involve contrast agents or ionising radiation, and p…
View article: Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles
Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles Open
Huntingtin protein, mutated in Huntington disease, is implicated in nucleic acid- mediated processes, yet evidence for direct huntingtin-nucleic acid interaction is limited. Here we show wildtype and mutant huntingtin co-purify with nuclei…
View article: DEveloping BBB-ASL as non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD): Study design
DEveloping BBB-ASL as non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD): Study design Open
Introduction: Arterial spin labeling (ASL) MRI, a non-invasive technique for imaging perfusion, now allows studying BBB permeability. The DEveloping BBB-ASL as a non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD) multi-cohort …
View article: Determinants of Time to Diagnosis in Young-Onset Dementia
Determinants of Time to Diagnosis in Young-Onset Dementia Open
Timely diagnosis of young-onset dementia (YOD) is critical. This study aimed to identify factors that increased time to diagnosis at each stage of the diagnostic pathway. Participants were patients diagnosed with YOD (n = 40) and their car…
View article: Investigating the association between white matter fiber density in the superior longitudinal fasciculus and inhibitory control in groups at‐risk of Alzheimer’s disease
Investigating the association between white matter fiber density in the superior longitudinal fasciculus and inhibitory control in groups at‐risk of Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is associated with poorer memory and reduced grey matter volume. Non‐amnestic cognition and white matter (WM) changes are an alternative line of enquiry and may reveal earlier changes. We investigated ho…
View article: The relevance of tract‐specific white matter hyperintensity burden to clinical impairment in groups at risk of Alzheimer’s disease
The relevance of tract‐specific white matter hyperintensity burden to clinical impairment in groups at risk of Alzheimer’s disease Open
Background White matter hyperintensities (WMHs) are common in normally functioning older adults. While greater WMH volume may be associated with an increased risk of cognitive dysfunction and dementia, the impact of the location of WMHs is…
View article: Plasma biomarkers across the Alzheimer’s disease continuum in the New Zealand‐Dementia Prevention Research Clinics
Plasma biomarkers across the Alzheimer’s disease continuum in the New Zealand‐Dementia Prevention Research Clinics Open
Background Advances in ultra‐sensitive immunoassay methods, like Single molecule array (Simoa) technology, show that Alzheimer’s disease (AD) neuropathology can be detected in blood at the earliest stages of AD. This study compared cross‐s…
View article: Increasing our understanding of emotion recognition impairment among frontotemporal dementias
Increasing our understanding of emotion recognition impairment among frontotemporal dementias Open
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View article: Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability
Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability Open
View article: Microglial and Astrocytic Responses in the Human Midcingulate Cortex in Huntington's Disease
Microglial and Astrocytic Responses in the Human Midcingulate Cortex in Huntington's Disease Open
Objective Patients with Huntington's disease can present with variable difficulties of motor functioning, mood, and cognition. Neurodegeneration occurs in the anterior cingulate cortex of some patients with Huntington's disease and is link…
View article: Decision-making capacity assessments in New Zealand and Australia: a systematised review
Decision-making capacity assessments in New Zealand and Australia: a systematised review Open
In an ageing world with a growing prevalence of neurodegenerative disease and recent voluntary assisted dying laws in New Zealand and several Australian states, healthcare professionals are increasingly being relied upon to conduct decisio…
View article: Kumanu Tāngata—The Aftermatch Project: Neurodegenerative Disease Epidemiology in Former First-Class New Zealand Rugby Players
Kumanu Tāngata—The Aftermatch Project: Neurodegenerative Disease Epidemiology in Former First-Class New Zealand Rugby Players Open
View article: Antagonistic roles of canonical and alternative RPA in tandem CAG repeat diseases
Antagonistic roles of canonical and alternative RPA in tandem CAG repeat diseases Open
Tandem CAG repeat expansion mutations cause >15 neurodegenerative diseases, where ongoing expansions in patients’ brains are thought to drive disease onset and progression. Repeat length mutations will involve single-stranded DNAs prone to…
View article: N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease
N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease Open
View article: Dementia Prevention Research Clinic: a longitudinal study investigating factors influencing the development of Alzheimer’s disease in Aotearoa, New Zealand
Dementia Prevention Research Clinic: a longitudinal study investigating factors influencing the development of Alzheimer’s disease in Aotearoa, New Zealand Open
Aotearoa New Zealand's population is ageing. Increasing life expectancy is accompanied by increases in prevalence of Alzheimer's Disease (AD) and ageing-related disorders. The multicentre Dementia Prevention Research Clinic longitudinal st…
View article: The New Zealand Genetic Frontotemporal Dementia Study (FTDGeNZ): a longitudinal study of pre-symptomatic biomarkers
The New Zealand Genetic Frontotemporal Dementia Study (FTDGeNZ): a longitudinal study of pre-symptomatic biomarkers Open
The New Zealand Genetic Frontotemporal Dementia Study (FTDGeNZ) is an emerging longitudinal study of a large New Zealand pedigree with genetic frontotemporal dementia (FTD). Natural history studies of genetic FTD cohorts provide a unique o…
View article: N-terminal mutant Huntingtin deposition correlates with CAG repeat length and disease onset, but not neuronal loss in Huntington’s disease
N-terminal mutant Huntingtin deposition correlates with CAG repeat length and disease onset, but not neuronal loss in Huntington’s disease Open
Huntington’s disease (HD) is caused by a CAG repeat expansion mutation in the gene encoding the huntingtin (Htt) protein, with mutant Htt protein subsequently forming aggregates within the brain. Mutant Htt is a current target for novel th…
View article: Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia Open
Cerebral blood flow (CBF) measured with arterial spin labelling (ASL) magnetic resonance imaging (MRI) reflects cerebral perfusion, related to metabolism, and arterial transit time (ATT), related to vascular health. Our aim was to investig…