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View article: Leveraging the global genomic epidemiology of carbapenemase-producing Klebsiella pneumoniae to inform infection prevention in Tunisian hospitals
Leveraging the global genomic epidemiology of carbapenemase-producing Klebsiella pneumoniae to inform infection prevention in Tunisian hospitals Open
Introduction: Habib Bourguiba Hospital (HBH) in Sfax, Tunisia, a 500-bed regional medical center, experienced profound increases in carbapenemase-producing Klebsiella pneumoniae (CPK) infections over 2009-2022. Given limited resources, we …
View article: Learning ecosystem-scale dynamics from microbiome data with MDSINE2
Learning ecosystem-scale dynamics from microbiome data with MDSINE2 Open
Although dynamical systems models are a powerful tool for analysing microbial ecosystems, challenges in learning these models from complex microbiome datasets and interpreting their outputs limit use. We introduce the Microbial Dynamical S…
View article: Prospective whole genome sequencing to aid the identification and control of methicillin-susceptible Staphylococcus aureus transmissions in a neonatal ICU
Prospective whole genome sequencing to aid the identification and control of methicillin-susceptible Staphylococcus aureus transmissions in a neonatal ICU Open
Prospective genotyping of surveillance and clinical methicillin-susceptible Staphylococcus aureus (MSSA) isolates in a neonatal intensive care unit over a 26-month period identified multiple MSSA clusters that were otherwise unappreciated …
View article: Polyunsaturated fatty acids promote appetite via the microbiome-gut-brain axis
Polyunsaturated fatty acids promote appetite via the microbiome-gut-brain axis Open
Appetite is regulated by nutrient-sensing systems that integrate long-term signals from energy stores and short-term cues from dietary intake, yet this regulation is increasingly disrupted by industrialized diets. Although the physiologica…
View article: Automated Segmentation of Forearm Muscles: Clinical Associations With Hand Function, Muscle Volume and Intramuscular Fat
Automated Segmentation of Forearm Muscles: Clinical Associations With Hand Function, Muscle Volume and Intramuscular Fat Open
Background Hand function is critical for daily activities and declines early in many diseases, conditions or disorders affecting the musculoskeletal and neurologic systems. Muscle health markers derived from clinically available magnetic r…
View article: Clostridioides difficile’s virulence requires efficient holin-mediated toxin secretion
Clostridioides difficile’s virulence requires efficient holin-mediated toxin secretion Open
View article: (092) A PROTOCOL FOR EVALUATION OF SEXUAL SIDE EFFECTS OF GLP-1 INHIBITOR MEDICATIONS
(092) A PROTOCOL FOR EVALUATION OF SEXUAL SIDE EFFECTS OF GLP-1 INHIBITOR MEDICATIONS Open
Introduction Glucagon-like-peptide-1 (GLP-1) agonists are medications that mimic the action of the postprandial hormone GLP-1, which causes increased pancreatic production of insulin and consequently cell uptake of glucose (1). GLP-1 agoni…
View article: (086) DEVELOPMENT OF A SURVEY TO ASSESS WOMEN’S SEXUAL HEALTH PROVIDERS’ AWARENESS AND APPROACH TOWARD PEYRONIE’S DISEASE AND THE IMPACT ON THE FEMALE SEXUAL PARTNER
(086) DEVELOPMENT OF A SURVEY TO ASSESS WOMEN’S SEXUAL HEALTH PROVIDERS’ AWARENESS AND APPROACH TOWARD PEYRONIE’S DISEASE AND THE IMPACT ON THE FEMALE SEXUAL PARTNER Open
Introduction Peyronie’s disease (PD) is a connective tissue disorder characterized by the development of collagen-containing plaques in the tunica albuginea. This alteration results in penile deformities that are most evident during erecti…
View article: A Small-Molecule Inhibitor of Gut Bacterial Urease Protects the Host from Liver Injury
A Small-Molecule Inhibitor of Gut Bacterial Urease Protects the Host from Liver Injury Open
Hyperammonemia is characterized by the accumulation of ammonia within the bloodstream upon liver injury. Left untreated, hyperammonemia contributes to conditions such as hepatic encephalopathy that have high rates of patient morbidity and …
View article: Prospective Whole Genome Sequencing to Aid the Identification and Control of Methicillin-Susceptible Staphylococcus Aureus Transmissions in a Neonatal ICU
Prospective Whole Genome Sequencing to Aid the Identification and Control of Methicillin-Susceptible Staphylococcus Aureus Transmissions in a Neonatal ICU Open
View article: Evidence that minocycline treatment confounds the interpretation of neurofilament as a biomarker
Evidence that minocycline treatment confounds the interpretation of neurofilament as a biomarker Open
Neurofilament light (NfL) concentration in CSF and blood serves as an important biomarker in neurology drug development. Changes in NfL are generally assumed to reflect changes in neuronal damage, while little is known about the clearance …
View article: Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice
Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice Open
Dietary lipids play an essential role in regulating the function of the gut microbiota and gastrointestinal tract, and these luminal interactions contribute to mediating host metabolism. Palmitic Acid Hydroxy Stearic Acids (PAHSAs) are a f…
View article: Evidence that minocycline treatment confounds the interpretation of neurofilament as a biomarker
Evidence that minocycline treatment confounds the interpretation of neurofilament as a biomarker Open
Neurofilament light (NfL) concentration in cerebrospinal fluid (CSF) and blood serves as an important biomarker in neurology drug development. Changes in NfL are generally assumed to reflect changes in neuronal damage, while little is know…
View article: Longitudinal Microbiome Changes in Children Exposed to Proton Pump Inhibitors
Longitudinal Microbiome Changes in Children Exposed to Proton Pump Inhibitors Open
INTRODUCTION: Proton pump inhibitor (PPI) use has been associated with an increased risk of gastrointestinal and upper respiratory infections in children. There are limited longitudinal data on the effect of PPI in children. The goal of th…
View article: Approaching toxigenic Clostridia from a One Health perspective
Approaching toxigenic Clostridia from a One Health perspective Open
View article: Microbial butyrate capacity is reduced in inflamed mucosa in patients with ulcerative colitis
Microbial butyrate capacity is reduced in inflamed mucosa in patients with ulcerative colitis Open
Reduced butyrate-production capacity has been reported in fecal microbial communities in patients with active ulcerative colitis. However, the butyrate-production capacity of the mucosal microbiome from active vs quiescent mucosa in ulcera…
View article: Approaching pathogenic<i>Clostridia</i>from a One Health perspective
Approaching pathogenic<i>Clostridia</i>from a One Health perspective Open
Spore-forming pathogens have a unique capacity to thrive in diverse environments, and with temporal persistence afforded through their ability to sporulate. These behaviors require a One Health approach to identify critical reservoirs and …
View article: <i>Clostridioides difficile</i>MreE (PBP2) variants facilitate clinical disease during cephalosporin exposures
<i>Clostridioides difficile</i>MreE (PBP2) variants facilitate clinical disease during cephalosporin exposures Open
Cephalosporins are the most common triggers of healthcare-associated Clostridioides difficile infections (CDI). Here, we confirm gene-level drivers of cephalosporin resistance and their roles in promoting disease. Genomic-epidemiologic ana…
View article: Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice
Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice Open
Dietary lipids play an essential role in regulating the function of the gut microbiota and gastrointestinal tract, and these luminal interactions contribute to mediating host metabolism. PAHSAs are a class of lipids with anti-diabetic and …
View article: HRMAS<sup>13</sup>C NMR and genome-scale metabolic modeling identify threonine as a preferred dual redox substrate for<i>Clostridioides difficile</i>
HRMAS<sup>13</sup>C NMR and genome-scale metabolic modeling identify threonine as a preferred dual redox substrate for<i>Clostridioides difficile</i> Open
Stickland-fermenting Clostridia preferentially ferment amino acids to generate energy and anabolic substrates for growth. In gut ecosystems, these species prefer dual redox substrates, particularly mucin-abundant leucine. Here, we establis…
View article: The TcdE holin drives toxin secretion and virulence in<i>Clostridioides difficile</i>
The TcdE holin drives toxin secretion and virulence in<i>Clostridioides difficile</i> Open
Clostridioides difficile is the leading cause of healthcare associated infections. The Pathogenicity Locus (PaLoc) toxins TcdA and TcdB promote host disease. These toxins lack canonical N-terminal signal sequences for translocation across …
View article: Central<i>in vivo</i>mechanisms by which<i>C. difficile’s</i>proline reductase drives efficient metabolism, growth, and toxin production
Central<i>in vivo</i>mechanisms by which<i>C. difficile’s</i>proline reductase drives efficient metabolism, growth, and toxin production Open
Clostridioides difficile (CD) is a sporulating and toxin-producing nosocomial pathogen that opportunistically infects the gut, particularly in patients with depleted microbiota after antibiotic exposure. Metabolically, CD rapidly generates…
View article: Indole-3-Propionic Acid, a Gut Microbiota Metabolite, Protects Against the Development of Postoperative Delirium
Indole-3-Propionic Acid, a Gut Microbiota Metabolite, Protects Against the Development of Postoperative Delirium Open
Objective: The aim was to determine preoperative gut microbiota metabolites that may be associated with postoperative delirium (POD) development in patients and further study in rodents. Summary Background Data: POD occurs in 9% to 50% of …
View article: Prospective Genomic Surveillance Reveals Cryptic MRSA Outbreaks with Local to International Origins among NICU Patients
Prospective Genomic Surveillance Reveals Cryptic MRSA Outbreaks with Local to International Origins among NICU Patients Open
Methicillin-resistant Staphylococcus aureus (MRSA) infections cause substantive morbidity and mortality in neonates. Using publicly available resources from the National Center of Biotechnology Information (NCBI) and Food and Drug Administ…
View article: Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut
Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut Open
View article: Elucidating dynamic anaerobe metabolism with HRMAS 13C NMR and genome-scale modeling
Elucidating dynamic anaerobe metabolism with HRMAS 13C NMR and genome-scale modeling Open
Anaerobic microbial metabolism drives critical functions within global ecosystems, host–microbiota interactions, and industrial applications, yet remains ill-defined. Here we advance a versatile approach to elaborate cellular metabolism in…
View article: Gut metabolites predict Clostridioides difficile recurrence
Gut metabolites predict Clostridioides difficile recurrence Open
This repository contains:\n\n\n1. Data used for analyses from:\n\n\nA) 16S rRNA gene amplicon analysis after paired-end Fastq files were truncated, filtered, denoised, and merged ["1-ASV_Counts.xlsx"]\n\n\nB) Untargeted metabolom…
View article: Gut metabolites predict Clostridioides difficile recurrence
Gut metabolites predict Clostridioides difficile recurrence Open
This repository contains: 1. Data used for analyses from: A) 16S rRNA gene amplicon analysis after paired-end Fastq files were truncated, filtered, denoised, and merged ["1-ASV_Counts.xlsx"] B) Untargeted metabolomics as provided by Metabo…
View article: Intelectin-1 binds and alters the localization of the mucus barrier–modifying bacterium <i>Akkermansia muciniphila</i>
Intelectin-1 binds and alters the localization of the mucus barrier–modifying bacterium <i>Akkermansia muciniphila</i> Open
Intelectin-1 (ITLN1) is a lectin secreted by intestinal epithelial cells (IECs) and upregulated in human ulcerative colitis (UC). We investigated how ITLN1 production is regulated in IECs and the biological effects of ITLN1 at the host–mic…
View article: Gut metabolites predict Clostridioides difficile recurrence
Gut metabolites predict Clostridioides difficile recurrence Open
This repository contains: 1. Data used for analyses from: A) 16S rRNA gene amplicon analysis after paired-end Fastq files were truncated, filtered, denoised, and merged ["1-ASV_Counts.xlsx"] B) Untargeted metabolomics as provided by Metabo…