Lynn Rasmussen
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View article: A high-throughput human tissue model for respiratory viruses: Automating the use of human airway epithelial tissues for faster drug discovery
A high-throughput human tissue model for respiratory viruses: Automating the use of human airway epithelial tissues for faster drug discovery Open
View article: Pregabalin produces analgesia in males but not females in an animal model of chronic widespread muscle pain
Pregabalin produces analgesia in males but not females in an animal model of chronic widespread muscle pain Open
Introduction: Pregabalin, which acts on the α 2 δ-1 subunit of voltage-gated calcium channels, relieves ≥50% of pain in a third of individuals with fibromyalgia. Thus far, preclinical studies of pregabalin have predominantly used male anim…
View article: A high-throughput response to the SARS-CoV-2 pandemic
A high-throughput response to the SARS-CoV-2 pandemic Open
Four years after the beginning of the COVID-19 pandemic, it is important to reflect on the events that have occurred during that time and the knowledge that has been gained. The response to the pandemic was rapid and highly resourced; it w…
View article: High-Throughput cell-based immunofluorescence assays against influenza
High-Throughput cell-based immunofluorescence assays against influenza Open
View article: Genetic Depletion Of Acid-Sensing Ion Channel 3 In Macrophage/Monocytes Prevents Development Of Activity-Induced Muscle Pain
Genetic Depletion Of Acid-Sensing Ion Channel 3 In Macrophage/Monocytes Prevents Development Of Activity-Induced Muscle Pain Open
View article: P2X7-NLRP3-Caspase-1 signaling mediates activity-induced muscle pain in male but not female mice
P2X7-NLRP3-Caspase-1 signaling mediates activity-induced muscle pain in male but not female mice Open
We developed an animal model of activity-induced muscle pain that is dependent on local macrophage activation and release of interleukin-1β (IL-1β). Activation of purinergic type 2X (P2X) 7 receptors recruits the NOD-like receptor protein …
View article: Triamterene Functions as an Effective Nonsense Suppression Agent for MPS I-H (Hurler Syndrome)
Triamterene Functions as an Effective Nonsense Suppression Agent for MPS I-H (Hurler Syndrome) Open
Mucopolysaccharidosis I-Hurler (MPS I-H) is caused by the loss of α-L-iduronidase, a lysosomal enzyme that degrades glycosaminoglycans. Current therapies cannot treat many MPS I-H manifestations. In this study, triamterene, an FDA-approved…
View article: Selective androgen receptor modulator microparticle formulation reverses muscle hyperalgesia in a mouse model of widespread muscle pain
Selective androgen receptor modulator microparticle formulation reverses muscle hyperalgesia in a mouse model of widespread muscle pain Open
Chronic pain is a significant health problem associated with disability and reduced quality of life. Current management of chronic pain is inadequate with only modest effects of pharmacological interventions. Thus, there is a need for the …
View article: Selective Androgen Receptor Modulator Microparticle Formulation Reverses Muscle Hyperalgesia in Mouse Model of Widespread Muscle Pain
Selective Androgen Receptor Modulator Microparticle Formulation Reverses Muscle Hyperalgesia in Mouse Model of Widespread Muscle Pain Open
Currently, there is a need for the generation of non-opioid analgesics for treating chronic pain. Preclinical and clinical studies demonstrate the analgesic effects of testosterone. However, treatment with testosterone is not feasible due …
View article: Novel Compound Inhibitors of HIV-1NL4-3 Vpu
Novel Compound Inhibitors of HIV-1NL4-3 Vpu Open
HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further…
View article: Resistance training protects against muscle pain through activation of androgen receptors in male and female mice
Resistance training protects against muscle pain through activation of androgen receptors in male and female mice Open
Resistance training–based exercise is commonly prescribed in the clinic for the treatment of chronic pain. Mechanisms of aerobic exercise for analgesia are frequently studied, while little is known regarding resistance training mechanisms.…
View article: Fighting SARS-CoV-2 with green seaweed <i>Ulva</i> sp. extract: extraction protocol predetermines crude ulvan extract anti-SARS-CoV-2 inhibition properties in <i>in vitro</i> Vero-E6 cells assay
Fighting SARS-CoV-2 with green seaweed <i>Ulva</i> sp. extract: extraction protocol predetermines crude ulvan extract anti-SARS-CoV-2 inhibition properties in <i>in vitro</i> Vero-E6 cells assay Open
Due to the global COVID-19 pandemic, there is a need to screen for novel compounds with antiviral activity against SARS-COV-2. Here we compared chemical composition and the in vitro anti- SARS-COV-2 activity of two different Ulva sp. crude…
View article: Peer Review #2 of "Fighting SARS-CoV-2 with green seaweed Ulva sp. extract: extraction protocol predetermines crude ulvan extract anti-SARS-CoV-2 inhibition properties in in vitro Vero-E6 cells assay (v0.1)"
Peer Review #2 of "Fighting SARS-CoV-2 with green seaweed Ulva sp. extract: extraction protocol predetermines crude ulvan extract anti-SARS-CoV-2 inhibition properties in in vitro Vero-E6 cells assay (v0.1)" Open
Due to the global COVID19 pandemic, there is a need to screen for novel compounds with antiviral activity against SARS-COV-2.Here we compared chemical composition and thein vitroanti-SARS-COV-2 activity of two differentUlva sp.crude ulvan …
View article: Novel compound inhibitors of HIV-1<sub>NL4-3</sub> Vpu
Novel compound inhibitors of HIV-1<sub>NL4-3</sub> Vpu Open
HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further…
View article: Identification of Quinolinones as Antivirals against Venezuelan Equine Encephalitis Virus
Identification of Quinolinones as Antivirals against Venezuelan Equine Encephalitis Virus Open
Venezuelan equine encephalitis virus (VEEV) is a reemerging alphavirus that can cause encephalitis resulting in severe human morbidity and mortality. Using a high-throughput cell-based screen, we identified a quinolinone compound that prot…
View article: Inhibiting SARS‐CoV‐2 infection with lysosomal alkalizers
Inhibiting SARS‐CoV‐2 infection with lysosomal alkalizers Open
Understanding the SARS‐CoV‐2 virus’ routes of infection, virus–host–protein interactions, and mechanisms of virus‐induced cytopathic effects will greatly aid in the discovery and design of new therapeutics to treat COVID‐19. Chloroquine an…
View article: Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors
Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors Open
A benzo[6]annulene, 4-(tert-butyl)-N-(3-methoxy-5,6,7,8-tetrahydronaphthalen-2-yl) benzamide (1a), was identified as an inhibitor against Chikungunya virus (CHIKV) with antiviral activity EC90 = 1.45 μM and …
View article: Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2
Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2 Open
Drug repurposing is a rapid approach to identify therapeutics for the treatment of emerging infectious diseases such as COVID-19. To address the urgent need for treatment options, we carried out a quantitative high-throughput screen using …
View article: Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design
Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design Open
The macrodomain of nsP3 (nsP3MD) is highly conserved among the alphaviruses and ADP-ribosylhydrolase activity of Chikungunya Virus (CHIKV) nsP3MD is critical for CHIKV viral replication and virulence. No small molecule drugs targeting CHIK…
View article: The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules
The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules Open
Understanding the SARS-CoV-2 virus' pathways of infection, virus-host-protein interactions, and mechanisms of virus-induced cytopathic effects will greatly aid in the discovery and design of new therapeutics to treat COVID-19. Chloroquine …
View article: Regular physical activity reduces the percentage of spinally projecting neurons that express mu-opioid receptors from the rostral ventromedial medulla in mice
Regular physical activity reduces the percentage of spinally projecting neurons that express mu-opioid receptors from the rostral ventromedial medulla in mice Open
Introduction: Regular physical activity/exercise is an effective nonpharmacological treatment for individuals with chronic pain. Central inhibitory mechanisms, involving serotonin and opioids, are critical to analgesia produced by regular …
View article: Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2
Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2 Open
Drug repurposing is a rapid approach to identifying therapeutics for the treatment of emerging infectious diseases such as COVID-19. To address the urgent need for treatment options, we carried out a quantitative high-throughput screen usi…
View article: Testosterone protects against the development of widespread muscle pain in mice
Testosterone protects against the development of widespread muscle pain in mice Open
Chronic widespread pain conditions are more prevalent in women than men, suggesting a role for gonadal hormones in the observed differences. Previously, we showed that female mice, compared to male, develop widespread, more severe, and lon…
View article: Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus
Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus Open
Alphaviruses are arthropod-transmitted members of the Togaviridae family that can cause severe disease in humans, including debilitating arthralgia and severe neurological complications. Currently, there are no approved vaccines or antivir…
View article: The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators
The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators Open
SARS-CoV-2 is a new type of coronavirus capable of rapid transmission and causing severe clinical symptoms; much of which has unknown biological etiology. It has prompted researchers to rapidly mobilize their efforts towards identifying an…
View article: Regular physical activity reduces the percentage of spinally projecting neurons that express mu-opioid receptors from the RVM
Regular physical activity reduces the percentage of spinally projecting neurons that express mu-opioid receptors from the RVM Open
Regular physical activity/exercise is an effective non-pharmacological treatment for individuals with chronic pain. Central inhibitory mechanisms, involving serotonin and opioids, are critical to analgesia produced by regular physical acti…
View article: P2X4 Receptors on Muscle Macrophages Are Required for Development of Hyperalgesia in an Animal Model of Activity-Induced Muscle Pain
P2X4 Receptors on Muscle Macrophages Are Required for Development of Hyperalgesia in an Animal Model of Activity-Induced Muscle Pain Open
View article: Revisiting the β-Lactams for Tuberculosis Therapy with a Compound-Compound Synthetic Lethality Approach
Revisiting the β-Lactams for Tuberculosis Therapy with a Compound-Compound Synthetic Lethality Approach Open
The suboptimal effectiveness of β-lactam antibiotics against Mycobacterium tuberculosis has hindered the utility of this compound class for tuberculosis treatment. However, the results of treatment with a second-line regimen containing mer…
View article: Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategies
Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategies Open
Over the past two decades, ribosome biogenesis has emerged as an attractive target for cancer treatment. In this study, two high-throughput screens were used to identify ribosome biogenesis inhibitors. Our primary screen made use of the Ha…
View article: High-throughput screening and Bayesian machine learning for copper-dependent inhibitors of <i>Staphylococcus aureus</i>
High-throughput screening and Bayesian machine learning for copper-dependent inhibitors of <i>Staphylococcus aureus</i> Open
One potential source of new antibacterials is through probing existing chemical libraries for copper-dependent inhibitors (CDIs), i.e., molecules with antibiotic activity only in the presence of copper. Recently, our group demonstrated tha…