Lynn Wardlow
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View article: Daptomycin versus beta-lactam based therapy for the treatment of enterococcal endocarditis and other endovascular infections: a retrospective cohort study
Daptomycin versus beta-lactam based therapy for the treatment of enterococcal endocarditis and other endovascular infections: a retrospective cohort study Open
Outcomes were similar among patients with EIE treated with daptomycin versus beta-lactams. Larger, prospective studies are needed to confirm this finding.
View article: Implementing use of cystatin C‐guided estimated glomerular filtration rate for medication dosing at an Academic Medical Center
Implementing use of cystatin C‐guided estimated glomerular filtration rate for medication dosing at an Academic Medical Center Open
Accurate kidney function assessment is essential for medication dosing, although traditional methods such as urine output and serum creatinine are limited, especially in patients with acute kidney injury. Cystatin C was made available as a…
View article: Low- versus high-dose trimethoprim-sulfamethoxazole for the treatment of <i>Stenotrophomonas maltophilia</i> pneumonia
Low- versus high-dose trimethoprim-sulfamethoxazole for the treatment of <i>Stenotrophomonas maltophilia</i> pneumonia Open
Objective: To compare outcomes of patients treated with low-dose (LD) versus high-dose (HD) trimethoprim-sulfamethoxazole (TMP-SMX) for Stenotrophomonas maltophilia pneumonia. Design: Retrospective cohort study. Setting: Large academic ter…
View article: A Resident-Preceptor Collaboration to Encourage Wellness and Reduce Burnout Amongst Pharmacy Residents
A Resident-Preceptor Collaboration to Encourage Wellness and Reduce Burnout Amongst Pharmacy Residents Open
Pharmacy residents are especially vulnerable to burnout given the professional and personal stressors associated with postgraduate training. Residency programs need to prioritize burnout reduction strategies to support resident health and …
View article: Development of <scp>8‐h</scp> urine collections and an augmented renal clearance dosing program at an academic medical center
Development of <span>8‐h</span> urine collections and an augmented renal clearance dosing program at an academic medical center Open
Ensuring appropriate dosing of medications is an essential practice of clinical pharmacists. Dose adjustments in the setting of decreased renal function are common but may also be warranted for patients with supraphysiologic or augmented r…
View article: Clinical Outcomes with Ertapenem for Pneumonia in Obese versus Nonobese Patients
Clinical Outcomes with Ertapenem for Pneumonia in Obese versus Nonobese Patients Open
The objective of this study was to compare the rate of pneumonia resolution in obese (body mass index [BMI], ≥30 kg/m 2 ) and nonobese (BMI, <30 kg/m 2 ) patients treated with 1 gram ertapenem daily. In this retrospective cohort study, we …
View article: Clinical Outcomes With Definitive Treatment of Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia With Retained Daptomycin and Ceftaroline Combination Therapy vs De-escalation to Monotherapy With Vancomycin, Daptomycin, or Ceftaroline
Clinical Outcomes With Definitive Treatment of Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia With Retained Daptomycin and Ceftaroline Combination Therapy vs De-escalation to Monotherapy With Vancomycin, Daptomycin, or Ceftaroline Open
Background Lower mortality has been observed with combination therapy compared to monotherapy for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia; however, there is a lack of evidence for continued combination therapy over de…
View article: Clinical Outcomes of Daptomycin Versus Anti-Staphylococcal Beta-Lactams in Definitive Treatment of Methicillin-susceptible Staphylococcus aureus Bloodstream Infections
Clinical Outcomes of Daptomycin Versus Anti-Staphylococcal Beta-Lactams in Definitive Treatment of Methicillin-susceptible Staphylococcus aureus Bloodstream Infections Open
Staphylococcus aureus (S. aureus) is the leading cause of bacteraemia and infective endocarditis worldwide. The preferred management of patients with methicillin-susceptible S. aureus (MSSA) bacteraemia includes definitive therapy with int…
View article: 272. Clinical Outcomes with Continuation of Combination Antibiotic Therapy versus De-escalation to Monotherapy for Patients with MRSA Bacteremia
272. Clinical Outcomes with Continuation of Combination Antibiotic Therapy versus De-escalation to Monotherapy for Patients with MRSA Bacteremia Open
Background Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with increased morbidity and mortality. Previous studies have demonstrated lower mortality with combination therapy (CT) compared to monother…
View article: Clinical Impact of an Antibiotic Time Out Initiative at an Academic Medical Center
Clinical Impact of an Antibiotic Time Out Initiative at an Academic Medical Center Open
Background: Various strategies aimed at limiting inappropriate antimicrobial use including antibiotic time out (ATO) have been proposed to combat the development of antimicrobial resistance, yet there are limited studies that have assessed…
View article: 177. Clinical Outcomes of Daptomycin vs. Anti-Staphylococcal β-Lactams in Definitive Treatment of Methicillin-Susceptible Staphylococcus aureus (MSSA) Bloodstream Infections
177. Clinical Outcomes of Daptomycin vs. Anti-Staphylococcal β-Lactams in Definitive Treatment of Methicillin-Susceptible Staphylococcus aureus (MSSA) Bloodstream Infections Open
Background The preferred management of patients with MSSA bacteremia includes definitive therapy with intravenous anti-staphylococcal β-lactam antibiotics. In β-lactam allergic or intolerant patients, daptomycin has been targeted as a viab…
View article: 1036. Clinical impact of an antibiotic time out initiative at an academic medical center
1036. Clinical impact of an antibiotic time out initiative at an academic medical center Open
Background The Infectious Diseases Society of America’s guideline for implementing antibiotic (abx) stewardship recommends routine review of abx use. Several studies demonstrate antibiotic time out (ATO) programs result in de-escalation, b…
View article: Trends in and Predictors of Carbapenem Consumption across North American Hospitals: Results from a Multicenter Survey by the MAD-ID Research Network
Trends in and Predictors of Carbapenem Consumption across North American Hospitals: Results from a Multicenter Survey by the MAD-ID Research Network Open
We sought to define trends in and predictors of carbapenem consumption across community, teaching, and university-affiliated hospitals in the United States and Canada. We conducted a retrospective multicenter survey of carbapenem and broad…
View article: 334. Implementation of FilmArray Meningitis/Encephalitis Panel at a Tertiary Medical Center
334. Implementation of FilmArray Meningitis/Encephalitis Panel at a Tertiary Medical Center Open
BACKGROUND: A rapid and accurate meningitis/encephalitis diagnostic test can have a significant clinical impact and improve utilization of antimicrobial agents. The FilmArray Meningitis/Encephalitis Panel, a multiplex PCR meningitis/enceph…
View article: 1484. Impact of Combination Vs. Monotherapy on Clinical Outcomes Associated with <i>Stenotrophomonas maltophilia</i> Pneumonia
1484. Impact of Combination Vs. Monotherapy on Clinical Outcomes Associated with <i>Stenotrophomonas maltophilia</i> Pneumonia Open
BACKGROUND: Stenotrophomonas maltophilia is an emerging nosocomial pathogen with intrinsic resistance to several antibiotics, making it potentially challenging to treat. Studies have demonstrated treatment failures and resistance developme…
View article: Preparing for The Joint Commission Standard on Antimicrobial Stewardship: Practical Tips for Survey Success
Preparing for The Joint Commission Standard on Antimicrobial Stewardship: Practical Tips for Survey Success Open
Results.In 2013, >1 antibiotic dose/day was prescribed to 16.2% of VA dental patients (total = 476,451 patients).By class, aminopenicillins were most frequently prescribed (69.4%), followed by lincomycins (21.9%).The overall mean AD was 11…
View article: Clinical Outcomes with Penicillin Vs. Alternative Β-Lactams in the Treatment of Penicillin-Susceptible Staphylococcus aureus Bacteremia
Clinical Outcomes with Penicillin Vs. Alternative Β-Lactams in the Treatment of Penicillin-Susceptible Staphylococcus aureus Bacteremia Open
The prevalence of penicillin-susceptible S. aureus (PSSA) has increased in recent years. However, non-penicillin β-lactams (BLs) are often utilized for the treatment of PSSA bacteremia. To date, there are limited data on the management of …