Lynne A. Holtzclaw
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View article: Liver-specific loss of <i>Atg9a</i> perturbs lipid metabolism and hepatocyte integrity
Liver-specific loss of <i>Atg9a</i> perturbs lipid metabolism and hepatocyte integrity Open
The autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional Atg9a knockout (Atg9a-cKO) mou…
View article: Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice
Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice Open
View article: Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain Open
View article: Single Cell Sequencing of the Pineal Gland: The Next Chapter
Single Cell Sequencing of the Pineal Gland: The Next Chapter Open
The analysis of pineal cell biology has undergone remarkable development as techniques have become available which allow for sequencing of entire transcriptomes and, most recently, the sequencing of the transcriptome of individual cells. I…
View article: Index
Index Open
View article: Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo
Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo Open
Neurolastin is a dynamin family GTPase that also contains a RING domain and exhibits both GTPase and E3 ligase activities. It is specifically expressed in the brain and is important for synaptic transmission, as neurolastin knockout animal…
View article: Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression
Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression Open
The vertebrate pineal gland is dedicated to the production of the hormone melatonin, which increases at night to influence circadian and seasonal rhythms. This increase is associated with dramatic changes in the pineal transcriptome. Here,…
View article: Using double pulsed-field gradient MRI to study tissue microstructure in traumatic brain injury (TBI)
Using double pulsed-field gradient MRI to study tissue microstructure in traumatic brain injury (TBI) Open