Explanipedia

The Values and Preferences of People Living With Motor Neurone Disease (MND): A Systematic Review Protocol Open

Timothy Hugh Barker, Grace Holland, Camille Schubert, Danielle Pollock, Cindy Stern , et al. · 2025

Objective To systematically review the values and preferences of people with lived experience of motor neurone disease (MND), including those living with MND, caregivers and genetic carriers, regarding their health‐related outcomes. Introd…

Long-Term Protection Against Invasive Meningococcal B Disease and Gonococcal Infection 5 Years After Implementation of Funded Childhood and Adolescent 4CMenB Vaccination Program in South Australia: An Observational Cohort and Case-Control Study Open

Bing Wang, Lynne Giles, Prabha H. Andraweera, Mark McMillan, Rebecca Beazley , et al. · 2025

Background A publicly funded 4CMenB program has been implemented in South Australia since 2018. We aimed to evaluate vaccine effectiveness (VE) and vaccine impact on invasive meningococcal B (MenB) disease and gonococcal infections 5 years…

Bifidobacteria support optimal infant vaccine responses Open

Feargal J. Ryan, Michelle Clarke, Miriam A. Lynn, Saoirse C. Benson, Sonia McAlister , et al. · 2025

Sneak peek: food, waste and packaging characteristics of South Australian school children’s lunchboxes Open

Neha Lalchandani, Clare Hume, Lynne Giles, Shona Crabb, Jo Hendrikx , et al. · 2025

Objective: To characterise children’s lunchbox contents for food, waste and packaging. Design: A cross-sectional study was conducted. Lunchboxes were photographed at two time points on the same day: before first morning break to capture fo…

Long-term 4CMenB Vaccine Effectiveness Against Gonococcal Infection at Four Years Post–Program Implementation: Observational Case–Control Study Open

Bing Wang, Lynne Giles, Prabha H. Andraweera, Mark McMillan, Rebecca Beazley , et al. · 2024

Background A 4-component meningococcal B (4CMenB) vaccine program was introduced in adolescents in 2019 in South Australia. We aimed to evaluate long-term vaccine effectiveness (VE) and impact (VI) on gonococcal infection 4 years after imp…

Benefit of Early Oseltamivir Therapy for Adults Hospitalized With Influenza A: An Observational Study Open

Nathaniel M. Lewis, Elizabeth Harker, Lauren Grant, Yuwei Zhu, Carlos G. Grijalva , et al. · 2024

Background Clinical guidelines recommend initiation of antiviral therapy as soon as possible for patients hospitalized with confirmed or suspected influenza. Methods A multicenter US observational sentinel surveillance network prospectivel…

The Impact of Obesity on Influenza Vaccine Immunogenicity and Antibody Transfer to the Infant During Pregnancy Open

Michelle Clarke, Suja M. Mathew, Lynne Giles, Ian Barr, Peter Richmond , et al. · 2024

Background/Objectives: Influenza vaccination is recommended for pregnant women, offering the dual benefit of protecting pregnant women and their newborn infants against influenza. This study aimed to investigate the impact of body mass ind…

Clomiphene Citrate Medication for Infertility and Risk of Stillbirth or Neonatal Death: A Population-based Cohort Study Open

Vivienne Moore, Alice Rumbold, Renae Fernandez, Heather McElroy, Lynette Moore , et al. · 2024

Objective To assess associations between clomiphene citrate (CC) use and perinatal death. Design Whole of population data linkage cohort. Setting South Australia. Participants All women giving birth between July 2003 and December 2015 (n =…

Heatwaves and occupational injuries and illnesses risk varied at localised spatial scale: A national study in Australia Open

Syeda Fatima, Lynne Giles, Paul Rothmore, Blesson M. Varghese, Peng Bi · 2024

Public health management of invasive meningococcal disease outbreaks: worldwide 1973–2018, a systematic review Open

Brianna R. Morello, Adriana Milazzo, Helen Marshall, Lynne Giles · 2024

Maternal modifiable factors and risk of congenital heart defects: systematic review and causality assessment Open

Judith Streak Gomersall, Vivienne Moore, Renae Fernandez, Lynne Giles, Luke E. Grzeskowiak , et al. · 2024

Objective Primary prevention strategies are critical to reduce the global burden of congenital heart defects (CHDs); this requires robust knowledge of causal agents. We aimed to review associations between CHDs and maternal advanced age, o…

Energy and nutrient intake by 11–13-year-old young adolescents attending private schools in Delhi, India Open

Anupama Ivaturi, Lynne Giles, Loc Do, Tina Rawal, Monika Arora , et al. · 2024

There are no high-quality data on dietary behaviour of adolescents in India. This study aimed to assess the intake of energy (E), macronutrients and selected micronutrients in a sample of 11–13-year-old schoolchildren in Delhi, India. Part…

Sources and determinants of free sugars intake by 5‐year‐old Australian children in the SMILE cohort Open

Anupama Ivaturi, Loc Do, Lynne Giles, Gemma Devenish, Jane Scott , et al. · 2024

Reducing free sugars intake is important for the prevention of dental caries and obesity in children. The study aimed to determine the amount and sources of free sugars known to contribute to dental caries, and identify sociodemographic de…

Intake of energy and macronutrients in the diets of 11–13-year-old schoolchildren living in Delhi India Open

Paula Moynihan, Anupama Ivaturi, Lynne Giles, Loc Do, Tina Rawal , et al. · 2024

National surveys in India, through measures of anthropometry and biomarkers, have identified a triple burden of malnutrition (undernutrition, micronutrient deficiencies and overnutrition) in adolescents (1) . However, there is a dearth of …

Geographical distribution of invasive meningococcal disease and carriage: A spatial analysis Open

Adriana Milazzo, Mark McMillan, Lynne Giles, K.L. Page, Louise Flood , et al. · 2024

Little information exists concerning the spatial relationship between invasive meningococcal disease (IMD) cases and Neisseria meningitidis (N. meningitidis) carriage. The aim of this study was to examine whether there is a relationship be…

Heatwaves and Occupational Injuries and Illnesses Risk Varied at Localised Spatial Scale: A National Study in Australia Open

Syeda Hira Fatima, Lynne Giles, Paul Rothmore, Blesson M. Varghese, Peng Bi · 2024

P-767 Urogenital defects in live births to women dispensed clomiphene citrate: A study within a whole of population birth cohort Open

Michael J. Davies, Alice Rumbold, Lynette Moore, Rosa Rodríguez Fernández, Lynne Giles , et al. · 2023

Study question Is the risk of urogenital defects increased in live births where clomiphene citrate is known to have been dispensed by a pharmacist to the individual? Summary answer The risk of urogenital defects is elevated in singletons, …

Impacts of hot climatic conditions on work, health, and safety in Australia: A case study of policies in practice in the construction industry Open

Syeda Hira Fatima, Paul Rothmore, Lynne Giles, Peng Bi · 2023

CHARACTERISTICS OF MENINGOCOCCAL CLOSE CONTACTS AND THEIR PERCEPTIONS, BEHAVIOUR AND KNOWLEDGE OF THE CONTACT TRACING PROCESS Open

Adriana Milazzo, M. Sathiananthan, Lynne Giles, Helen Marshall · 2023

Intro: The aim of this study is to characterize close contacts of cases diagnosed with Invasive Meningococcal Disease (IMD) in further understanding their role in how IMD is spread and their experience throughout the contact tracing proces…

Protocol for a nested case-control study design for omics investigations in the Environmental Determinants of Islet Autoimmunity cohort Open

Helena Oakey, Lynne Giles, Rebecca L. Thomson, Kim‐Anh Lê Cao, Pat Ashwood , et al. · 2023

Background: The Environmental Determinants of Islet Autoimmunity (ENDIA) pregnancy-birth cohort investigates the developmental origins of type 1 diabetes (T1D), with recruitment between 2013 and 2019. ENDIA is the first study in the…

Intra-urban risk assessment of occupational injuries and illnesses associated with current and projected climate: Evidence from three largest Australian cities Open

Syeda Hira Fatima, Paul Rothmore, Lynne Giles, Peng Bi · 2023

Impacts of Hot Climate Conditions on Work Health and Safety in Australia: A Case Assessment of Policies in Practice in the Construction Industry Open

Syeda Hira Fatima, Paul Rothmore, Lynne Giles, Peng Bi · 2023

A comparison of survival models for prediction of eight-year revision risk following total knee and hip arthroplasty Open

Alana R. Cuthbert, Lynne Giles, Gary Glonek, Lisa M. Kalisch Ellett, Nicole Pratt · 2022

The impact of non‐pharmaceutical interventions on COVID‐19 cases in South Australia and Victoria Open

Adriana Milazzo, Lynne Giles, Natalie Parent, Sophie McCarthy, Caroline Laurence · 2022

Low case numbers and deaths in Australia's first wave of COVID-19 are thought to be due to the timely use of interventions. The observed two-week lag effect associated with a decrease in incidence provides justification for early implement…

A Prospective Study Investigating the Impact of Obesity on the Immune Response to the Quadrivalent Influenza Vaccine in Children and Adolescents Open

Michelle Clarke, Suja M. Mathew, Lynne Giles, Alexia Peña, Ian Barr , et al. · 2022

Obesity can increase the severity of influenza infection. Data are limited regarding immune responses to influenza vaccination in obese children. We aimed to investigate the impact of obesity on quadrivalent influenza vaccine responses in …

Effect of a multi-faceted rapid response system re-design on repeat calling of the rapid response team Open

Richard Chalwin, Amy Salter, Jonathan Karnon, Victoria Eaton, Lynne Giles · 2022

Background Repeat Rapid Response Team (RRT) calls are associated with increased in-hospital mortality risk and pose an organisation-level resource burden. Use of Non-Technical Skills (NTS) at calls has the potential to reduce potentially p…

An Observational Study to Assess the Effectiveness of 4CMenB against Meningococcal Disease and Carriage and Gonorrhea in Adolescents in the Northern Territory, Australia—Study Protocol Open

Helen Marshall, Prabha H. Andraweera, James Ward, John Kaldor, Ross Andrews , et al. · 2022

Invasive meningococcal disease (IMD) causes significant morbidity and mortality worldwide with serogroup B being the predominant serogroup in Australia and other countries for the past few decades. The licensed 4CMenB vaccine is effective …

690Growth in childhood and age at menarche: Insights from individual trajectory modelling Open

Lynne Giles, Melissa J. Whitrow, Alice Rumbold, Michael J. Davies, Vivienne Moore · 2021

Background The relationship between patterns of weight gain across childhood and the onset of puberty remains unclear. We aimed to derive growth parameters (size, tempo, and velocity) from models of weight across childhood and to estimate …

A Comparison of Survival Models for Prediction of Eight-year Revision Risk Following Total Knee and Hip Arthroplasty Open

Alana R. Cuthbert, Lynne Giles, Gary Glonek, Lisa M. Kalisch Ellett, Nicole Pratt · 2021

Background There is increasing interest in the development and use of clinical prediction models, but a lack of evidence-supported guidance on the merits of different modelling approaches. This is especially true for time-to-event outcomes…

Lessons for and from the COVID-19 pandemic response — An appraisal of guidance for the public health management of Invasive Meningococcal Disease Open

Brianna R. Morello, Adriana Milazzo, Helen Marshall, Lynne Giles · 2021

Discrepancies between guidelines could be due to limited evidence concerning mechanisms behind disease transmission, along with the lack of a consistent process for development and review of guideline recommendations. COVID-19 management h…

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