Lyon Bruinsma
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View article: Strategic redesign of the central metabolism in Pseudomonas putida boosts NADPH generation and product formation
Strategic redesign of the central metabolism in Pseudomonas putida boosts NADPH generation and product formation Open
The biotechnological synthesis of chemicals presents a greener and more sustainable alternative to traditional petrochemical processes. However, achieving titers, rates, and yields (TRY) allowing for economic competitiveness remains a sign…
View article: Shikimate pathway-dependent catabolism: enabling near-to-maximum production of aromatics
Shikimate pathway-dependent catabolism: enabling near-to-maximum production of aromatics Open
View article: Establishing microbial production of anisole
Establishing microbial production of anisole Open
View article: Shikimate pathway-Dependent Catabolism: enabling near-to-maximum production yield of aromatics
Shikimate pathway-Dependent Catabolism: enabling near-to-maximum production yield of aromatics Open
Catabolism is a complex network of tightly regulated metabolic reactions that provides energy and carbon to fuel anabolism in all living organisms. Rewiring catabolism is essential for harnessing industrial biotechnology but remains a subs…
View article: Shikimate pathway-Dependent Catabolism: enabling near-to-maximum production yield of aromatics
Shikimate pathway-Dependent Catabolism: enabling near-to-maximum production yield of aromatics Open
Catabolism is a complex network of tightly regulated metabolic reactions that provides energy and carbon to fuel anabolism in all living organisms. Rewiring catabolism is essential for harnessing industrial biotechnology but remains a subs…
View article: Paving the way for synthetic C1 - Metabolism in Pseudomonas putida through the reductive glycine pathway
Paving the way for synthetic C1 - Metabolism in Pseudomonas putida through the reductive glycine pathway Open
One-carbon (C1) compounds such as methanol, formate, and CO2 are alternative, sustainable microbial feedstocks for the biobased production of chemicals and fuels. In this study, we engineered the carbon metabolism of the industr…
View article: Increasing cellular fitness and product yields in Pseudomonas putida through an engineered phosphoketolase shunt
Increasing cellular fitness and product yields in Pseudomonas putida through an engineered phosphoketolase shunt Open
Background Pseudomonas putida has received increasing interest as a cell factory due to its remarkable features such as fast growth, a versatile and robust metabolism, an extensive genetic toolbox and its high tolerance to oxidative stress…
View article: Paving the way for synthetic C1- metabolism in Pseudomonas putida through the reductive glycine pathway
Paving the way for synthetic C1- metabolism in Pseudomonas putida through the reductive glycine pathway Open
One-carbon (C1) compounds such as methanol, formate, and CO2 are alternative, sustainable microbial feedstocks for the biobased production of chemicals and fuels. In this study, we engineered the carbon metabolism of the industrially impor…
View article: Paving the way for synthetic C1- metabolism in <i>Pseudomonas putida</i> through the reductive glycine pathway
Paving the way for synthetic C1- metabolism in <i>Pseudomonas putida</i> through the reductive glycine pathway Open
One-carbon (C1) compounds such as methanol, formate, and CO 2 are alternative, sustainable microbial feedstocks for the biobased production of chemicals and fuels. In this study, we engineered the carbon metabolism of the industrially impo…
View article: Increasing cellular fitness and product yields in Pseudomonas putida through an engineered phosphoketolase shunt
Increasing cellular fitness and product yields in Pseudomonas putida through an engineered phosphoketolase shunt Open
Background Pseudomonas putida as a cell factory is increasingly being used due to its remarkable features such as fast growth, versatile and robust metabolism, extensive genetic toolbox and high tolerance to oxidative stress and toxic comp…
View article: Global Transcriptional Response of Aspergillus niger to Blocked Active Citrate Export through Deletion of the Exporter Gene
Global Transcriptional Response of Aspergillus niger to Blocked Active Citrate Export through Deletion of the Exporter Gene Open
Aspergillus niger is the major industrial citrate producer worldwide. Export as well as uptake of citric acid are believed to occur by active, proton-dependent, symport systems. Both are major bottlenecks for industrial citrate production.…
View article: A navigation guide of synthetic biology tools for Pseudomonas putida
A navigation guide of synthetic biology tools for Pseudomonas putida Open
View article: Expression of the Alternative Oxidase Influences JNK Signaling and Cell Migration
Expression of the Alternative Oxidase Influences JNK Signaling and Cell Migration Open
View article: Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration
Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration Open
Downregulation of Jun N-terminal kinase (JNK) signaling inhibits cell migration in diverse model systems. In Drosophila pupal development, attenuated JNK signaling in the thoracic dorsal epithelium leads to defective midline closure…
View article: <i>Aspergillus niger</i>citrate exporter revealed by comparison of two alternative citrate producing conditions
<i>Aspergillus niger</i>citrate exporter revealed by comparison of two alternative citrate producing conditions Open
Currently, there is no consensus regarding the mechanism underlying Aspergillus niger citrate biosynthesis and secretion, although it is amongst the most studied biotechnological production processes. Carbon excess relative to various othe…