Lyonell B. Kone
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View article: Combination LIGHT overexpression and checkpoint blockade disrupts the tumor immune environment impacting colorectal liver metastases
Combination LIGHT overexpression and checkpoint blockade disrupts the tumor immune environment impacting colorectal liver metastases Open
Colorectal cancer and liver metastases are a leading cause of cancer-related mortality. Overexpression of the immunostimulatory cytokine TNFSF14/LIGHT associates with improved survival and correlates with increased tumor-infiltrating lymph…
View article: Best Model Selection for Extreme Values Analysis Using the Peaks-Over-Threshold Method and the Annual Maximum Method: Case Study of Bamako, Mali
Best Model Selection for Extreme Values Analysis Using the Peaks-Over-Threshold Method and the Annual Maximum Method: Case Study of Bamako, Mali Open
View article: Porcelain gallbladder in a 4-year-old male: A case report
Porcelain gallbladder in a 4-year-old male: A case report Open
Introduction: Porcelain gallbladder (PGB) is a gallbladder with calcium encrusted on its inner wall. PGB is rare in the pediatric population with only four cases reported in the literature. We present a patient who is the youngest reported…
View article: Non-Canonical Activin A Signaling Stimulates Context-Dependent and Cellular-Specific Outcomes in CRC to Promote Tumor Cell Migration and Immune Tolerance
Non-Canonical Activin A Signaling Stimulates Context-Dependent and Cellular-Specific Outcomes in CRC to Promote Tumor Cell Migration and Immune Tolerance Open
We have shown that activin A (activin), a TGF-β superfamily member, has pro-metastatic effects in colorectal cancer (CRC). In lung cancer, activin activates pro-metastatic pathways to enhance tumor cell survival and migration while augment…
View article: Robotic pancreatic and liver surgery is being done more frequently: Are we getting better or bolder?
Robotic pancreatic and liver surgery is being done more frequently: Are we getting better or bolder? Open
View article: Robotic Surgery for Biliary Tract Cancer
Robotic Surgery for Biliary Tract Cancer Open
Biliary tract cancer consists of cholangiocarcinoma (CC) and gallbladder cancer (GBC). When resectable, surgery provides the best chance at long-term survival. Unfortunately, surgery for these tumors is associated with long operative times…
View article: LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer
LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer Open
Increased tumor infiltrating lymphocytes (TIL) are associated with improved patient responses to immunotherapy. As a result, there is interest in enhancing lymphocyte trafficking particularly to colon cancers since the majority are checkpo…
View article: Surgeon-placed continuous infusion pain catheters markedly decrease narcotic use and improve outcomes after pancreatectomy
Surgeon-placed continuous infusion pain catheters markedly decrease narcotic use and improve outcomes after pancreatectomy Open
View article: One size doesn't fit all: different antibiotics are associated with decreases in surgical site infections in pancreaticoduodenectomy versus distal pancreatectomy
One size doesn't fit all: different antibiotics are associated with decreases in surgical site infections in pancreaticoduodenectomy versus distal pancreatectomy Open
View article: Preoperative Radiotherapy Is Not Associated with Increased Post-mastectomy Short-term Morbidity: Analysis of 77,902 Patients
Preoperative Radiotherapy Is Not Associated with Increased Post-mastectomy Short-term Morbidity: Analysis of 77,902 Patients Open
Background: Neoadjuvant radiotherapy (NRT) enhances breast-conserving surgery outcomes, reducing local recurrence of breast cancer and increasing median survival. However, its effect on postoperative morbidity remains under-studied. We sou…