Lyuba Salih
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View article: Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats
Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats Open
Paraneoplastic neurological syndromes arise from autoimmune reactions against nervous system antigens due to a maladaptive immune response to a peripheral cancer. Patients with small cell lung carcinoma or malignant thymoma can develop an …
View article: Cholesterol Inhibits HCN Channels through Dual Mechanisms in Neuropathic Pain
Cholesterol Inhibits HCN Channels through Dual Mechanisms in Neuropathic Pain Open
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate the excitability of dorsal root ganglion (DRG) neurons, particularly in the context of neuropathic pain. Cholesterol, a major component of lipid-ordered membrane d…
View article: Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy
Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy Open
Sensory neuronopathies (SNN) and small fiber neuropathies (SFN) are debilitating disorders associated with neuropathic pain, yet their underlying mechanisms remain poorly understood. Autoantibodies against fibroblast growth factor receptor…
View article: Nociceptors are functionally male or female: from mouse to monkey to man
Nociceptors are functionally male or female: from mouse to monkey to man Open
The prevalence of many pain conditions often differs between sexes. In addition to such quantitative distinctions, sexual dimorphism may also be qualitative reflecting differences in mechanisms that promote pain in men and women. A major f…
View article: Mechanism, and treatment of anti-CV2/CRMP5 autoimmune pain
Mechanism, and treatment of anti-CV2/CRMP5 autoimmune pain Open
Paraneoplastic neurological syndromes arise from autoimmune reactions against nervous system antigens due to a maladaptive immune response to a peripheral cancer. Patients with small cell lung carcinoma or malignant thymoma can develop an …
View article: Membrane Lipid Nanodomains Modulate HCN Pacemaker Channels in Nociceptor DRG Neurons
Membrane Lipid Nanodomains Modulate HCN Pacemaker Channels in Nociceptor DRG Neurons Open
Cell membranes consist of heterogeneous lipid nanodomains that influence key cellular processes. Using FRET-based fluorescent assays and fluorescence lifetime imaging microscopy (FLIM), we found that the dimension of cholesterol-enriched o…
View article: Progranulin Protects against Hyperglycemia-Induced Neuronal Dysfunction through GSK3β Signaling
Progranulin Protects against Hyperglycemia-Induced Neuronal Dysfunction through GSK3β Signaling Open
Type II diabetes affects over 530 million individuals worldwide and contributes to a host of neurological pathologies. Uncontrolled high blood glucose (hyperglycemia) is a major factor in diabetic pathology, and glucose regulation is a com…