Mark A. Geyer
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View article: Quantifying exploratory behavior in the human behavioral pattern monitor using automated video tracking
Quantifying exploratory behavior in the human behavioral pattern monitor using automated video tracking Open
Exploration is an essential adaptive function across many species. Distinct exploratory behavior patterns have been observed across several neuropsychiatric conditions, such as schizophrenia and bipolar disorder, leading to the refinement …
View article: Modulation of ventromedial orbitofrontal cortical glutamatergic activity affects the explore-exploit balance and influences value-based decision-making
Modulation of ventromedial orbitofrontal cortical glutamatergic activity affects the explore-exploit balance and influences value-based decision-making Open
The balance between exploration and exploitation is essential for decision-making. The present study investigated the role of ventromedial orbitofrontal cortex (vmOFC) glutamate neurons in mediating value-based decision-making by first usi…
View article: HIV Transgenic Rats Demonstrate Impaired Sensorimotor Gating But Are Insensitive to Cannabinoid (Δ9-Tetrahydrocannabinol)-Induced Deficits
HIV Transgenic Rats Demonstrate Impaired Sensorimotor Gating But Are Insensitive to Cannabinoid (Δ9-Tetrahydrocannabinol)-Induced Deficits Open
Background HIV-associated neurocognitive disorder (HAND) is commonly observed in persons living with HIV (PWH) and is characterized by cognitive deficits implicating disruptions of fronto-striatal neurocircuitry. Such circuitry is also sus…
View article: Advancing drug discovery for schizophrenia
Advancing drug discovery for schizophrenia Open
Sponsored by the New York Academy of Sciences and with support from the National Institute of Mental Health, the Life Technologies Foundation, and the Josiah Macy Jr. Foundation, "Advancing Drug Discovery for Schizophrenia" was held March …
View article: The Effects of Cannabis Use on Cognitive Function in Healthy Aging: A Systematic Scoping Review
The Effects of Cannabis Use on Cognitive Function in Healthy Aging: A Systematic Scoping Review Open
Background Older adults (≥50 years) represent the fastest-growing population of people who use cannabis, potentially due to the increasing promotion of cannabis as medicine by dispensaries and cannabis websites. Given healthy aging and can…
View article: Sustained attention and vigilance deficits associated with HIV and a history of methamphetamine dependence
Sustained attention and vigilance deficits associated with HIV and a history of methamphetamine dependence Open
Background Human immunodeficiency virus (HIV)-associated neurocognitive disorders persist in the era of antiretroviral therapy (ART). One factor that is elevated among persons with HIV (PWH) and independently associated with neurocognitive…
View article: Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts
Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts Open
To reveal post-traumatic stress disorder (PTSD) genetic risk influences on tissue-specific gene expression, we use brain and non-brain transcriptomic imputation. We impute genetically regulated gene expression (GReX) in 29,539 PTSD cases a…
View article: The effects of cannabis use on cognitive function in healthy aging: A systematic scoping review
The effects of cannabis use on cognitive function in healthy aging: A systematic scoping review Open
Middle-to-older-aged adults (>50 years) represent the fastest-growing cannabis-using population. Given aging and cannabis use are associated with cognitive decline, it is important to establish the effects of cannabis on cognitive function…
View article: The Relationship between Cannabis Use and Cognition in People with Bipolar Disorder: A Systematic Scoping Review
The Relationship between Cannabis Use and Cognition in People with Bipolar Disorder: A Systematic Scoping Review Open
Bipolar disorder (BD) and cannabis use are highly comorbid and are each associated with cognitive impairment. It is therefore important to understand the relationship between cannabis use and cognition in people with BD, as cannabis use in…
View article: Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter‐deficient mice using the 5‐choice CPT
Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter‐deficient mice using the 5‐choice CPT Open
Objectives Bipolar disorder (BD) is a debilitating psychiatric illness affecting 2%‐5% of the population. Although mania is the cardinal feature of BD, inattention and related cognitive dysfunction are observed across all stages. Since cog…
View article: Analysis of Genetically Regulated Gene Expression identifies a trauma type specific PTSD gene, SNRNP35
Analysis of Genetically Regulated Gene Expression identifies a trauma type specific PTSD gene, SNRNP35 Open
SUMMARY PTSD has significant genetic heritability; however, it is unclear how genetic risk influences tissue-specific gene expression. We used brain and non-brain transcriptomic imputation models to impute genetically regulated gene expres…
View article: Erratum
Erratum Open
[This corrects the article DOI: 10.1159/000480349.].
View article: Amphetamine Modestly Improves Conners’ Continuous Performance Test Performance in Healthy Adults
Amphetamine Modestly Improves Conners’ Continuous Performance Test Performance in Healthy Adults Open
Objectives: Amphetamine improves vigilance as assessed by continuous performance tests (CPT) in children and adults with attention deficit hyperactivity disorder (ADHD). Less is known, however, regarding amphetamine effects on vigilance in…