François M. Abboud
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View article: Peripheral MicroRNA Signatures in Adolescent Depression
Peripheral MicroRNA Signatures in Adolescent Depression Open
These findings lay the groundwork for identifying adolescent peripheral miRNA markers that reflect neurodevelopmental pathways that shape lifelong psychopathology risk.
View article: Altering Early Life Gut Microbiota Has Long-Term Effect on Immune System and Hypertension in Spontaneously Hypertensive Rats
Altering Early Life Gut Microbiota Has Long-Term Effect on Immune System and Hypertension in Spontaneously Hypertensive Rats Open
Hypertension is regulated by immunological components. Spontaneously hypertensive rats (SHR) display a large population of proinflammatory CD161 + immune cells. We investigated the effect of early post-natal gut microbiota on the developme…
View article: Renal denervation and CD161a immune ablation prevent cholinergic hypertension and renal sodium retention
Renal denervation and CD161a immune ablation prevent cholinergic hypertension and renal sodium retention Open
Cholinergic receptor activation leads to premature development of hypertension and infiltration of proinflammatory CD161a + /CD68 + M1 macrophages into the renal medulla. Renal inflammation is implicated in renal sodium retention and the d…
View article: Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults
Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults Open
Muscle sympathetic nerve activity (MSNA) influences the mechanical properties (ie, vascular smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether MSNA contributes to stiffness of central arteries, s…
View article: The continuous heart failure spectrum: moving beyond an ejection fraction classification
The continuous heart failure spectrum: moving beyond an ejection fraction classification Open
Randomized clinical trials initially used heart failure (HF) patients with low left ventricular ejection fraction (LVEF) to select study populations with high risk to enhance statistical power. However, this use of LVEF in clinical trials …
View article: TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons
TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons Open
The satiety effects and metabolic actions of cholecystokinin (CCK) have been recognized as potential therapeutic targets in obesity for decades. We identified a potentially novel Ca2+-activated chloride (Cl-) current (CaCC) that is induced…
View article: Angiotensin II-induced hypertension and cardiac hypertrophy are differentially mediated by TLR3- and TLR4-dependent pathways
Angiotensin II-induced hypertension and cardiac hypertrophy are differentially mediated by TLR3- and TLR4-dependent pathways Open
Toll-like receptors (TLR) are key components of the innate immune system that elicit inflammatory responses through the adaptor proteins myeloid differentiation protein 88 (MyD88) and Toll-interleukin receptor domain-containing adaptor pro…
View article: PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex Open
Heart rate and blood pressure control PIEZO1 and PIEZO2 are two mechanically activated ion channels that are highly expressed in lungs, bladder, and skin. Zeng et al. found that both ion channels are expressed in sensory neurons of a gangl…
View article: Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety
Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety Open
Relative burst amplitude of muscle sympathetic nerve activity (MSNA) is an indicator of augmented sympathetic outflow and contributes to greater vasoconstrictor responses. Evidence suggests anxiety-induced augmentation of relative MSNA bur…
View article: Increased receptor activity-modifying protein 1 in the nervous system is sufficient to protect against autonomic dysregulation and hypertension
Increased receptor activity-modifying protein 1 in the nervous system is sufficient to protect against autonomic dysregulation and hypertension Open
Calcitonin gene-related peptide (CGRP) can cause migraines, yet it is also a potent vasodilator that protects against hypertension. Given the emerging role of CGRP-targeted antibodies for migraine prevention, an important question is wheth…
View article: Autonomic regulation of the immune system in cardiovascular diseases
Autonomic regulation of the immune system in cardiovascular diseases Open
The autonomic nervous system is a powerful regulator of circulatory adjustments to acute hemodynamic stresses. Here we focus on new concepts that emphasize the chronic influence of the sympathetic and parasympathetic systems on cardiovascu…
View article: The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH
The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH Open
The leucine rich repeat containing protein 8A (LRRC8A), or SWELL1, is an essential component of the volume-regulated anion channel (VRAC) that is activated by cell swelling and ionic strength. We report here for the first time to our knowl…
View article: Nicotine Mediates CD161a<sup>+</sup>Renal Macrophage Infiltration and Premature Hypertension in the Spontaneously Hypertensive Rat
Nicotine Mediates CD161a<sup>+</sup>Renal Macrophage Infiltration and Premature Hypertension in the Spontaneously Hypertensive Rat Open
Rationale: Renal inflammation contributes to the pathophysiology of hypertension. CD161a + immune cells are dominant in the (SHR) spontaneously hypertensive rat and expand in response to nicotinic cholinergic activation. Objective: We aime…
View article: Dual Activation of TRIF and MyD88 Adaptor Proteins by Angiotensin II Evokes Opposing Effects on Pressure, Cardiac Hypertrophy, and Inflammatory Gene Expression
Dual Activation of TRIF and MyD88 Adaptor Proteins by Angiotensin II Evokes Opposing Effects on Pressure, Cardiac Hypertrophy, and Inflammatory Gene Expression Open
Hypertension is recognized as an immune disorder whereby immune cells play a defining role in the genesis and progression of the disease. The innate immune system and its component toll-like receptors are key determinants of the immunologi…