Marleen H. C. Abma-Henkens
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View article: Effect of increased CpG and UpA dinucleotides in the West Nile virus genome on virus transmission by <i>Culex</i> mosquitoes and pathogenesis in a vertebrate host
Effect of increased CpG and UpA dinucleotides in the West Nile virus genome on virus transmission by <i>Culex</i> mosquitoes and pathogenesis in a vertebrate host Open
Vertebrate animals and many small DNA and single-stranded RNA viruses that infect vertebrates have evolved to suppress genomic CpG dinucleotides. All organisms and most viruses additionally suppress UpA dinucleotides in protein-coding RNA.…
View article: The effect of increased CpG and UpA dinucleotides in the West Nile virus genome on virus transmission by <i>Culex</i> mosquitoes and pathogenesis in a vertebrate host
The effect of increased CpG and UpA dinucleotides in the West Nile virus genome on virus transmission by <i>Culex</i> mosquitoes and pathogenesis in a vertebrate host Open
Vertebrate animals and many small DNA and single-stranded RNA viruses that infect vertebrates have evolved to suppress genomic CpG dinucleotides. All organisms and most viruses additionally suppress UpA dinucleotides in protein coding RNA.…
View article: Comparative Efficacy of Mayaro Virus-Like Particle Vaccines Produced in Insect or Mammalian Cells
Comparative Efficacy of Mayaro Virus-Like Particle Vaccines Produced in Insect or Mammalian Cells Open
Mayaro virus (MAYV) is associated with acute rheumatic disease that can be debilitating and can evolve into months of chronic arthralgia. MAYV is believed to have the potential to emerge as a tropical public health threat, especially if it…
View article: The invasive Asian bush mosquito Aedes japonicus found in the Netherlands can experimentally transmit Zika virus and Usutu virus
The invasive Asian bush mosquito Aedes japonicus found in the Netherlands can experimentally transmit Zika virus and Usutu virus Open
Given that Ae. japonicus can experimentally transmit arthropod-borne viruses (arboviruses) like ZIKV and USUV and is currently expanding its territories, we should consider this mosquito as a potential vector for arboviral diseases in Euro…
View article: Conserved motifs in the hypervariable domain of chikungunya virus nsP3 required for transmission by Aedes aegypti mosquitoes
Conserved motifs in the hypervariable domain of chikungunya virus nsP3 required for transmission by Aedes aegypti mosquitoes Open
The P-rich motif in CHIKV nsP3 is dispensable for transmission by mosquitoes. A single FGDF motif is sufficient for infection and dissemination in mosquitoes, but duplicate FGDF motifs are required for the efficient infection from the mosq…