M. Adelita Vizcaíno
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View article: IMG-122. PSMA uptake in glioblastoma: a diagnostic curveball in neuro-oncology
IMG-122. PSMA uptake in glioblastoma: a diagnostic curveball in neuro-oncology Open
OBJECTIVE To demonstrate that Prostate-specific membrane antigen (PSMA) PET imaging, though primarily used in prostate cancer surveillance, can reveal PSMA uptake in non-prostatic tumors due to neovascular PSMA expression. BACKGROUND PSMA …
View article: Comparing loss of p16 and MTAP expression in detecting <i>CDKN2A</i> homozygous deletion in pleomorphic xanthoastrocytoma
Comparing loss of p16 and MTAP expression in detecting <i>CDKN2A</i> homozygous deletion in pleomorphic xanthoastrocytoma Open
Pleomorphic xanthoastrocytomas (PXAs) harbor CDKN2A homozygous deletion in >90% of cases, resulting in loss of p16 expression by immunohistochemistry. Considering the proximity of MTAP to CDKN2A and their frequent concurrent deletions, …
View article: Primary Leptomeningeal Lymphoma: Clinicopathologic Features of 2 Rare Phenotypes
Primary Leptomeningeal Lymphoma: Clinicopathologic Features of 2 Rare Phenotypes Open
Primary leptomeningeal lymphoma is exceedingly rare. We describe 2 rare lymphoma cases with exclusive leptomeningeal disease: 1 ALK-positive (ALK+) anaplastic large cell lymphoma (ALCL) and 1 primary effusion lymphoma (PEL). Case 1: A 19-y…
View article: Evaluating neurosurgical biopsies for CNS tumor diagnoses: An algorithmic and pattern based approach.
Evaluating neurosurgical biopsies for CNS tumor diagnoses: An algorithmic and pattern based approach. Open
The 2016 and 2021 World Health Organization (WHO) Classifications of Tumors of the Central Nervous System (CNS) reflect the importance of integrating molecular analysis into CNS tumor diagnosis and classification, adding to the complexity …
View article: Surgical Experience and Management of Intracranial Neurenteric Cysts: Single-Center Experience and Review of the Literature
Surgical Experience and Management of Intracranial Neurenteric Cysts: Single-Center Experience and Review of the Literature Open
Introduction Neurenteric cysts (NECs) are rare, congenital lesions lined by endodermal cell-derived columnar or cuboidal epithelium. Based on previous studies, gross total removal of the capsule has been presumed to be the ideal surgical g…
View article: Diffuse Large B-Cell Lymphoma of Peripheral Nerve with Distinctive Pathological Features Resembling Primary CNS Lymphoma
Diffuse Large B-Cell Lymphoma of Peripheral Nerve with Distinctive Pathological Features Resembling Primary CNS Lymphoma Open
To the Editor:Involvement of cranial or peripheral nerves, nerve roots, and/or nerve plexuses by lymphoma, also referred as neurolymphomatosis, is uncommon (1).When present, it usually represents secondary involvement by systemic subtypes …
View article: An Unusual Case of EBV-Negative Primary CNS Lymphoma of Natural Killer/T-Cell Lineage
An Unusual Case of EBV-Negative Primary CNS Lymphoma of Natural Killer/T-Cell Lineage Open
Extranodal NK/T-cell lymphoma (ENKTL) is a well-defined cytotoxic lymphoma strongly associated with Epstein–Barr virus (EBV) infection, commonly affecting the nasopharynx and upper aerodigestive tract. Primary central nervous system (CNS) …
View article: Exophytic Lumbar Vertebral Body Mass in an Adult with Back Pain
Exophytic Lumbar Vertebral Body Mass in an Adult with Back Pain Open
Chordomas are rare primary bone malignancies derived from notochord remnants. The tumors often are slow-growing and often present with indolent, nonspecific symptoms. Nevertheless, chordomas are locally aggressive and highly prone to local…
View article: Localized Hypertrophic Neuropathy as a Neoplastic Manifestation of <i>KRAS</i>-Mediated RASopathy
Localized Hypertrophic Neuropathy as a Neoplastic Manifestation of <i>KRAS</i>-Mediated RASopathy Open
Localized hypertrophic neuropathy is a rare Schwann cell proliferation that usually affects single nerves from the extremities, and it is of unclear etiology in its pure form. RASopathies are a defined group of genetic diseases with overla…
View article: Alternative lengthening of telomeres, ATRX loss and H3‐K27M mutations in histologically defined pilocytic astrocytoma with anaplasia
Alternative lengthening of telomeres, ATRX loss and H3‐K27M mutations in histologically defined pilocytic astrocytoma with anaplasia Open
Anaplasia may be identified in a subset of tumors with a presumed pilocytic astrocytoma ( PA ) component or piloid features, which may be associated with aggressive behavior, but the biologic basis of this change remains unclear. Fifty‐sev…
View article: Orbital progressive transformation of germinal centers as part of the spectrum of IgG4-related ophthalmic disease: Clinicopathologic features of three cases
Orbital progressive transformation of germinal centers as part of the spectrum of IgG4-related ophthalmic disease: Clinicopathologic features of three cases Open
Progressive transformation of germinal centers (PTGC) is a form of follicular hyperplasia recently associated with immunoglobulin G4-related disease (IgG4-RD), but the ophthalmic manifestations of this combination are poorly described. In …
View article: Hemophagocytic Lymphohistiocytosis in Adults with Intraocular Involvement: Clinicopathologic Features of 3 Cases
Hemophagocytic Lymphohistiocytosis in Adults with Intraocular Involvement: Clinicopathologic Features of 3 Cases Open
Background/Aims: Hemophagocytic lymphohistiocytosis (HLH) is an infrequent inflammatory multisystemic syndrome. Only rare cases with ophthalmic involvement describing their pathologic features have been previously reported. Methods: We rep…
View article: Multiple myeloma masquerading as abducens palsy: A case report.
Multiple myeloma masquerading as abducens palsy: A case report. Open
Purpose: To report a case of abducens palsy as the presenting symptom of multiple myeloma Case report: A 68-year-old woman with a history of systemic hypertension presented complaining of constant horizontal diplopia in left gaze for six w…
View article: Long standing exophytic conjunctival papilloma infected with human papillomavirus
Long standing exophytic conjunctival papilloma infected with human papillomavirus Open
Background: Most conjunctival papillomas are benign in nature.However, any long standing conjunctival mass should not evade the surveillance of carcinogenicity.Presented here is a case of a long standing conjunctival papilloma (HPV) that s…
View article: Supplementary Material for: Hemophagocytic Lymphohistiocytosis in Adults with Intraocular Involvement: Clinicopathologic Features of 3 Cases
Supplementary Material for: Hemophagocytic Lymphohistiocytosis in Adults with Intraocular Involvement: Clinicopathologic Features of 3 Cases Open
Background/Aims: Hemophagocytic lymphohistiocytosis (HLH) is an infrequent inflammatory multisystemic syndrome. Only rare cases with ophthalmic involvement describing their pathologic features have been previously reported. Methods: We rep…