Lorraine M. Albritton
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View article: CD8+ T Cells Expressing an HLA-DR1 Chimeric Antigen Receptor Target Autoimmune CD4+ T Cells in an Antigen-Specific Manner and Inhibit the Development of Autoimmune Arthritis
CD8+ T Cells Expressing an HLA-DR1 Chimeric Antigen Receptor Target Autoimmune CD4+ T Cells in an Antigen-Specific Manner and Inhibit the Development of Autoimmune Arthritis Open
Ag-specific immunotherapy is a long-term goal for the treatment of autoimmune diseases; however developing a means of therapeutically targeting autoimmune T cells in an Ag-specific manner has been difficult. Through the engineering of an H…
View article: Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus
Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus Open
CD19-targeted CAR T cells show sustained CD19 + B cell depletion and profound therapeutic benefit in ameliorating disease in mouse models of lupus.
View article: Inhibition of melanocortin 1 receptor slows melanoma growth, reduces tumor heterogeneity and increases survival
Inhibition of melanocortin 1 receptor slows melanoma growth, reduces tumor heterogeneity and increases survival Open
Melanoma risk is increased in patients with mutations of melanocortin 1 receptor (MC1R) yet the basis for the increased risk remains unknown. Here we report in vivo evidence supporting a critical role for MC1R in regulating melanoma tumor …