M. Andrew Nesbit
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View article: Validation of a stall-side Immunoglobin assay for use in equine reproductive management.
Validation of a stall-side Immunoglobin assay for use in equine reproductive management. Open
View article: Topical mutant allele-specific siRNA delivery for treatment of Meesmann epithelial corneal dystrophy and elucidation of disease biomarkers
Topical mutant allele-specific siRNA delivery for treatment of Meesmann epithelial corneal dystrophy and elucidation of disease biomarkers Open
Proven in vivo efficacy is a key requirement for novel gene therapies proceeding to clinical trial. No gene therapies for corneal dystrophies have been able to progress into patient-led studies due to a lack of suitable animal models expre…
View article: Appraisal of Cardiovascular Risk Factors, Biomarkers, and OcularImaging in Cardiovascular Risk Prediction
Appraisal of Cardiovascular Risk Factors, Biomarkers, and OcularImaging in Cardiovascular Risk Prediction Open
Cardiovascular disease remains a leading cause of death worldwide despite the use of available cardiovascular disease risk prediction tools. Identification of high-risk individuals via risk stratification and screening at sub-clinical stag…
View article: Assessment of hemodynamic indices of conjunctival microvascular function in patients with coronary microvascular dysfunction
Assessment of hemodynamic indices of conjunctival microvascular function in patients with coronary microvascular dysfunction Open
View article: Assessment of Indices of Conjunctival Microvascular Function in Patients With and Without Obstructive Coronary Artery Disease
Assessment of Indices of Conjunctival Microvascular Function in Patients With and Without Obstructive Coronary Artery Disease Open
View article: INOCA affects more than the coronaries
INOCA affects more than the coronaries Open
Background Ischaemia with normal coronary arteries (INOCA) may result in disabling symptoms and has an association with adverse long-term prognosis. The diagnosis of INOCA necessitates invasive coronary angiography to perform a physiologic…
View article: Evaluation of the performance of a lateral flow device for quantitative detection of anti-SARS-CoV-2 IgG
Evaluation of the performance of a lateral flow device for quantitative detection of anti-SARS-CoV-2 IgG Open
View article: A novel algorithm for cardiovascular screening using conjunctival microcirculatory parameters and blood biomarkers
A novel algorithm for cardiovascular screening using conjunctival microcirculatory parameters and blood biomarkers Open
View article: Successful Proof-of-Concept for Topical Delivery of Novel Peptide ALM201 with Potential Usefulness for Treating Neovascular Eye Disorders
Successful Proof-of-Concept for Topical Delivery of Novel Peptide ALM201 with Potential Usefulness for Treating Neovascular Eye Disorders Open
ALM201 is a promising novel molecule with anti-inflammatory and antivascularization activity and is a strong candidate to meet the clinical need of a new, topically delivered therapeutic agent for treating inflammation and pathologic vascu…
View article: IgG antibody production and persistence to 6 months following SARS-CoV-2 vaccination: A Northern Ireland observational study
IgG antibody production and persistence to 6 months following SARS-CoV-2 vaccination: A Northern Ireland observational study Open
This study demonstrates that strong anti-spike protein antibody responses are evoked in almost all individuals that receive two doses of Oxford-AstraZeneca vaccine, and which largely persist beyond six months after first vaccination.
View article: User experience of home-based AbC-19 SARS-CoV-2 antibody rapid lateral flow immunoassay test
User experience of home-based AbC-19 SARS-CoV-2 antibody rapid lateral flow immunoassay test Open
View article: Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals
Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals Open
View article: Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose
Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose Open
Variants of SARS-CoV-2 may evade natural and vaccine induced immunity and monoclonal antibody immunotherapeutics. There is an urgent need to know how well antibodies, induced by healthy and Clinically Extremely Vulnerable (CEV) patients, w…
View article: User experience analysis of AbC-19 Rapid Test via lateral flow immunoassays for self-administrated SARS-CoV-2 antibody testing
User experience analysis of AbC-19 Rapid Test via lateral flow immunoassays for self-administrated SARS-CoV-2 antibody testing Open
View article: Evaluation of the IgG antibody response to SARS CoV-2 infection and performance of a lateral flow immunoassay: cross-sectional and longitudinal analysis over 11 months
Evaluation of the IgG antibody response to SARS CoV-2 infection and performance of a lateral flow immunoassay: cross-sectional and longitudinal analysis over 11 months Open
Objective To evaluate the dynamics and longevity of the humoral immune response to SARS-CoV-2 infection and assess the performance of professional use of the UK-RTC AbC-19 Rapid Test lateral flow immunoassay (LFIA) for the target condition…
View article: Assessment of the conjunctival microcirculation in adult patients with cyanotic congenital heart disease compared to healthy controls
Assessment of the conjunctival microcirculation in adult patients with cyanotic congenital heart disease compared to healthy controls Open
View article: Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls
Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls Open
View article: GNA11 Variants Identified in Patients with Hypercalcemia or Hypocalcemia
GNA11 Variants Identified in Patients with Hypercalcemia or Hypocalcemia Open
Familial hypocalciuric hypercalcemia type 2 (FHH2) and autosomal dominant hypocalcemia type 2 (ADH2) are due to loss- and gain-of-function mutations, respectively, of the GNA11 gene that encodes the G protein subunit Gα11, a signaling part…
View article: Laboratory evaluation of SARS-CoV-2 antibodies: detectable IgG up to 20 weeks post infection
Laboratory evaluation of SARS-CoV-2 antibodies: detectable IgG up to 20 weeks post infection Open
Background The SARS-CoV-2 pandemic necessitated rapid and global responses across all areas of healthcare, including an unprecedented interest in serological immunoassays to detect antibodies to the virus. The dynamics of the immune respon…
View article: Topical siRNA delivery to the cornea and anterior eye by hybrid silicon-lipid nanoparticles
Topical siRNA delivery to the cornea and anterior eye by hybrid silicon-lipid nanoparticles Open
The major unmet need and crucial challenge hampering the exciting potential of RNAi therapeutics in ophthalmology is to find an effective, safe and non-invasive means of delivering siRNA to the cornea. Although all tissues of the eye are a…
View article: Protein Analysis of the TGFBI<sup>R124H</sup> Mouse Model Gives Insight into Phenotype Development of Granular Corneal Dystrophy
Protein Analysis of the TGFBI<sup>R124H</sup> Mouse Model Gives Insight into Phenotype Development of Granular Corneal Dystrophy Open
Purpose Mutations in the transforming growth factor β‐induced protein (TGFBIp) are associated with TGFBI‐linked corneal dystrophies, which manifests as protein deposits in the cornea. A total of 70 different disease‐causing mutations have …
View article: Mutation-Independent Allele-Specific Editing by CRISPR-Cas9, a Novel Approach to Treat Autosomal Dominant Disease
Mutation-Independent Allele-Specific Editing by CRISPR-Cas9, a Novel Approach to Treat Autosomal Dominant Disease Open
View article: Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism
Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism Open
Hypoparathyroidism is genetically heterogeneous and characterized by low plasma calcium and parathyroid hormone (PTH) concentrations. X-linked hypoparathyroidism (XLHPT) in two American families is associated with interstitial deletion-ins…
View article: CRISPR/Cas9 gene editing demonstrates metabolic importance of GPR55 in the modulation of GIP release and pancreatic beta cell function
CRISPR/Cas9 gene editing demonstrates metabolic importance of GPR55 in the modulation of GIP release and pancreatic beta cell function Open
View article: Gene Editing for Corneal Stromal Regeneration
Gene Editing for Corneal Stromal Regeneration Open
View article: Capsid Engineering Overcomes Barriers Toward Adeno-Associated Virus Vector-Mediated Transduction of Endothelial Cells
Capsid Engineering Overcomes Barriers Toward Adeno-Associated Virus Vector-Mediated Transduction of Endothelial Cells Open
Endothelial cells (EC) are targets in gene therapy and regenerative medicine, but they are inefficiently transduced with adeno-associated virus (AAV) vectors of various serotypes. To identify barriers hampering efficient transduction and t…
View article: Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide
Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide Open
View article: Quantitative assessment of the conjunctival microcirculation using a smartphone and slit-lamp biomicroscope
Quantitative assessment of the conjunctival microcirculation using a smartphone and slit-lamp biomicroscope Open
View article: Late-onset lattice corneal dystrophy associated TGFBI p.H626R mutation in members of a Canadian family
Late-onset lattice corneal dystrophy associated TGFBI p.H626R mutation in members of a Canadian family Open
View article: Evaluation of TGFBI corneal dystrophy and molecular diagnostic testing
Evaluation of TGFBI corneal dystrophy and molecular diagnostic testing Open