Matthias Augustin
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View article: Epidemiology of nummular eczema – methodological approaches and outcomes from nationwide claims data analyses
Epidemiology of nummular eczema – methodological approaches and outcomes from nationwide claims data analyses Open
Summary Background and Objectives Nummular eczema (NE) is a chronic skin condition with limited epidemiologic data. This study estimates its prevalence, incidence and severity in Germany. Methods A cross‐sectional analysis (2016–2022) used…
View article: The <scp>SWITCH</scp> algorithm: An expert consensus on treat‐to‐target criteria for chronic prurigo
The <span>SWITCH</span> algorithm: An expert consensus on treat‐to‐target criteria for chronic prurigo Open
Background To date, the management of chronic prurigo (CPG; prurigo nodularis) relies on expert consensus and guidelines without providing detailed recommendations on long‐term treatment management. Objectives This study was initiated by a…
View article: Anchored Matching-Adjusted Indirect Comparison of the Long-Term Maintenance of Efficacy of Tralokinumab and Lebrikizumab in Patients with Moderate-to-Severe Atopic Dermatitis
Anchored Matching-Adjusted Indirect Comparison of the Long-Term Maintenance of Efficacy of Tralokinumab and Lebrikizumab in Patients with Moderate-to-Severe Atopic Dermatitis Open
Comparable maintenance of efficacy was observed between tralokinumab and lebrikizumab after 52 weeks of treatment among patients meeting response criteria at week 16.
View article: Family dermatology life quality index (F-DLQI): German validation and applicability to parents of infants and toddlers with dermatological conditions
Family dermatology life quality index (F-DLQI): German validation and applicability to parents of infants and toddlers with dermatological conditions Open
Parents of children with skin conditions face an additional caregiving burden and significant health-related quality of life (HRQoL) impairments. This study aimed to (1) test the psychometric properties of the German version of the Family …
View article: Comparative Analysis of Patient-Reported Outcomes in Chronic Pruritus: Patients with Chronic Liver or Kidney Diseases Exhibit Higher Psychological Distress than Those with Atopic Dermatitis
Comparative Analysis of Patient-Reported Outcomes in Chronic Pruritus: Patients with Chronic Liver or Kidney Diseases Exhibit Higher Psychological Distress than Those with Atopic Dermatitis Open
These results highlight the need for holistic, patient-centred management strategies that address both the physical and psychological aspects of CP.
View article: Large Eczema Area and Severity Index response at 2-year follow-up of patients treated with dupilumab in routine care of atopic dermatitis: results from the national registry TREATgermany
Large Eczema Area and Severity Index response at 2-year follow-up of patients treated with dupilumab in routine care of atopic dermatitis: results from the national registry TREATgermany Open
The TREATgermany registry was set up in 2016. We provide results on long-term dupilumab therapy in adults with moderate and severe atopic dermatitis (AD) in a routine care setting. The analysis cohort of 294 patients is one of the largest …
View article: How to Interpret Quality of Life Assessment of Patients With Chronic Wounds Using the Wound‐<scp>QoL</scp>
How to Interpret Quality of Life Assessment of Patients With Chronic Wounds Using the Wound‐<span>QoL</span> Open
The Wound‐QoL assesses patients' health‐related quality of life. Quick and valid interpretation of the results is crucial, but no thresholds have yet been established. Additionally, counting top box responses might be a quick approximation…
View article: Atypical Wounds in Chronic Graft‐Versus‐Host Disease and Peripheral Arterial Disease Caused by Tyrosine Kinase Inhibitors
Atypical Wounds in Chronic Graft‐Versus‐Host Disease and Peripheral Arterial Disease Caused by Tyrosine Kinase Inhibitors Open
The term “atypical wounds” primarily refers to lesions with immunological or cancerous etiologies. However, these wounds can also be drug‐induced. We report about a 32‐year‐old man with a 6‐year history of chronic myelogenous leukemia (CML…
View article: Effective management of psoriasis and psoriatic arthritis in a patient with systemic lupus erythematosus using deucravacitinib, mycophenolate mofetil and hydroxychloroquine
Effective management of psoriasis and psoriatic arthritis in a patient with systemic lupus erythematosus using deucravacitinib, mycophenolate mofetil and hydroxychloroquine Open
We report the case of a 32-year-old woman with severe psoriasis, psoriatic arthritis (PsA) and systemic lupus erythematosus (SLE), including lupus nephritis. Despite effective control of her SLE and PsA with hydroxychloroquine, mycophenola…
View article: Utilization and Costs of Laboratory Monitoring in Biological and Non-Biological Psoriasis Treatment – Large-Scale Claims Data Analysis
Utilization and Costs of Laboratory Monitoring in Biological and Non-Biological Psoriasis Treatment – Large-Scale Claims Data Analysis Open
Biologic therapies for psoriasis induce considerably higher monitoring costs than non-biological systemic drugs. Age and CCI were main predictors for higher utilization of laboratory services, indicating a medical rationale to perform more…
View article: Quality of Life Measurement in Autoimmune Blistering Diseases: Mutual Position Statement of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Autoimmune Blistering Diseases
Quality of Life Measurement in Autoimmune Blistering Diseases: Mutual Position Statement of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Autoimmune Blistering Diseases Open
The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient Oriented Outcomes and on Autoimmune Bullous Diseases (AIBD) collaborated on a position statement regarding the QoL instrument…
View article: Epidemiology and Health Care of Generalized Pustular Psoriasis in Germany – Methodology and Outcomes of Claims Data Analysis
Epidemiology and Health Care of Generalized Pustular Psoriasis in Germany – Methodology and Outcomes of Claims Data Analysis Open
Acknowledging that the observed frequency or costs associated with GPP may be underestimated due to a few inherent limitations is important. Differences in GPP coding behavior and diagnostic accuracy may contribute to variations in epidemi…
View article: Severity of psoriasis and its impact on patient-reported outcomes (PROs): real world evidence with brodalumab 210 mg from the LIBERO study
Severity of psoriasis and its impact on patient-reported outcomes (PROs): real world evidence with brodalumab 210 mg from the LIBERO study Open
LIBERO confirms the benefit of brodalumab on PROs including rapid and complete clearance of skin lesions, quality of life and individual patient benefits - irrespective of their disease severity.
View article: Patient-Reported Well-Being in Value-Based Routine Care Using Tildrakizumab: 52-week Interim Data of the Phase IV Positive Study
Patient-Reported Well-Being in Value-Based Routine Care Using Tildrakizumab: 52-week Interim Data of the Phase IV Positive Study Open
Tildrakizumab successfully contributes to value-based long-term health care for moderate-to-severe psoriasis by increasing patient wellbeing, QoL and clinical outcomes while showing very good safety and tolerability.
View article: Evolution of Drug Supply for Psoriasis from 2010 to 2022 – Real-World Claims Data Analysis in Germany
Evolution of Drug Supply for Psoriasis from 2010 to 2022 – Real-World Claims Data Analysis in Germany Open
In more than a decade, the use of innovative systemic drugs, especially biologicals, in Germany has increased substantially. Despite their high cost, biologic expenses per person have slightly decreased over time.
View article: Optimization of Basic Emollient Therapy for the Management of Xerosis Cutis
Optimization of Basic Emollient Therapy for the Management of Xerosis Cutis Open
Topical emollients are the mainstay of basic therapy for managing xerosis cutis (dry skin). In general, most emollient formulations are safe and effective for xerosis cutis and diseases associated with dry skin; however, several other fact…
View article: Case Report of a Patient With Psoriasis Vulgaris, Psoriatic Arthritis and Alopecia Universalis Successfully Treated With Tofacitinib and Methotrexate
Case Report of a Patient With Psoriasis Vulgaris, Psoriatic Arthritis and Alopecia Universalis Successfully Treated With Tofacitinib and Methotrexate Open
Psoriasis vulgaris and psoriatic arthritis are common diseases that can lead to considerable impairment of quality of life. The coexistence of alopecia universalis and psoriasis may suppose a therapeutic challenge. We report a 31‐year‐old …
View article: Understanding Dermatologists’ Acceptance of Digital Health Interventions: Cross-Sectional Survey and Cluster Analysis
Understanding Dermatologists’ Acceptance of Digital Health Interventions: Cross-Sectional Survey and Cluster Analysis Open
Background Digital health interventions (DHIs) have the potential to enhance dermatological care by improving quality, patient empowerment, and efficiency. However, adoption remains limited, particularly in Germany. Objective This study ex…
View article: Benefits and Limitations of Teledermatology in German Correctional Facilities: Cross-Sectional Analysis
Benefits and Limitations of Teledermatology in German Correctional Facilities: Cross-Sectional Analysis Open
Background Teledermatology consultations offer the advantage of rapid diagnosis and care. Since 2019, our institute at the University Medical Center Hamburg-Eppendorf has been part of an interdisciplinary team for teledermatology support i…
View article: Are Systemic Drug Choices for Psoriasis by Dermatologists Compatible with Psoriatic Arthritis? Data from the German National Psoriasis Registry PsoBest
Are Systemic Drug Choices for Psoriasis by Dermatologists Compatible with Psoriatic Arthritis? Data from the German National Psoriasis Registry PsoBest Open
Early and effective treatment of PsA is crucial to prevent persistent damage of the joints. Although most patients received recommended systemic treatment for PSO+PsA, there is a small number of patients with prescriptions addressing mainl…
View article: Communication and Therapy Planning for Patients of Reproductive Age Under Immunomodulatory Treatments for Psoriasis or Psoriatic Arthritis—Survey of the German National Psoriasis Registry PsoBest
Communication and Therapy Planning for Patients of Reproductive Age Under Immunomodulatory Treatments for Psoriasis or Psoriatic Arthritis—Survey of the German National Psoriasis Registry PsoBest Open
Background/Objective: During the systemic treatment of moderate to severe psoriasis in patients of reproductive age, contraindications and therapeutic peculiarities must be taken into account. Doctor–patient communication is crucial for th…
View article: Impact of malodour on health‐related quality of life of patients with chronic wounds due to volatile organic compounds
Impact of malodour on health‐related quality of life of patients with chronic wounds due to volatile organic compounds Open
Chronic wounds significantly impact health‐related quality of life (HRQoL). Unpleasant wound odour, caused by bacterial colonisation and necrotic processes, is a distressing symptom. Its exact composition is not well understood, but it cou…
View article: Understanding patient priorities in teledermatology for psoriasis: A discrete choice experiment
Understanding patient priorities in teledermatology for psoriasis: A discrete choice experiment Open
Background/Objectives Despite supporting guidelines and evidence, teledermatology adoption in Germany is low, also possibly due to a lack of services that reflect patients' preferences. This study investigates these preferences in psoriasi…
View article: Effect of spesolimab on sustained disease control in patients with generalized pustular psoriasis: Post hoc analysis of the EFFISAYIL 2 study
Effect of spesolimab on sustained disease control in patients with generalized pustular psoriasis: Post hoc analysis of the EFFISAYIL 2 study Open
Spesolimab 600 mg SC LD followed by 300 mg SC q4w provides sustained improvement of skin symptoms and QoL burden in a substantially higher proportion of patients with GPP versus placebo.