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View article: Seroprevalence of cytomegalovirus among pregnant women attending Murtala Muhammad Specialist Hospital, Kano
Seroprevalence of cytomegalovirus among pregnant women attending Murtala Muhammad Specialist Hospital, Kano Open
Cytomegalovirus (CMV) infection is a common cause of miscarriage, growth retardation and congenital infections in pregnancy. This congenital infection can cause serious disease to the foetus such as blindness and deafness. This study deter…
View article: Potential of fat-soluble vitamins as a platform for antiviral drug development
Potential of fat-soluble vitamins as a platform for antiviral drug development Open
Fat-soluble vitamins, including vitamins A, D, E, and K, exhibit antioxidative, anti-inflammatory, and immunomodulatory effects, making them promising candidates for antiviral drug development. This review highlights their structural featu…
View article: Design, Synthesis, and Anti-SARS-CoV-2 Activity of Amodiaquine Analogs
Design, Synthesis, and Anti-SARS-CoV-2 Activity of Amodiaquine Analogs Open
The pandemic of coronavirus disease 2019, caused by the new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a serious concern worldwide. Although some effective vaccines have been developed, only a few ant…
View article: Pyrazolo[3,4-<i>d</i>]pyrimidine-based neplanocin analogues identified as potential <i>de novo</i> pharmacophores for dual-target HBV inhibition
Pyrazolo[3,4-<i>d</i>]pyrimidine-based neplanocin analogues identified as potential <i>de novo</i> pharmacophores for dual-target HBV inhibition Open
Pyrazolo[3,4- d ]pyrimidine-based nucleoside as de-novo pharmacophore as dual-target HBV inhibitor.
View article: MOLECULAR TYPING OF HLA-B*27 SUB-ALLELES REVEALS AN ASSOCIATION WITH ERAP1 AND DISEASE SUBSET OF ANKYLOSING SPONDYLITIS IN NORTH-INDIAN (KASHMIR) POPULATION
MOLECULAR TYPING OF HLA-B*27 SUB-ALLELES REVEALS AN ASSOCIATION WITH ERAP1 AND DISEASE SUBSET OF ANKYLOSING SPONDYLITIS IN NORTH-INDIAN (KASHMIR) POPULATION Open
Background: Human Leukocyte Antigen(HLA)-B*27 is significantly linked to Ankylosing spondylitis(AS) and its presence aids in the diagnosis of the disease. Identification of HLA-B*27 allele plays an important role in the clinical monitoring…
View article: Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro
Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro Open
The persistence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of new mutant strains continue to present a substantial threat with potential for future pandemics. Safe, effective, and readily av…
View article: Exploring Novel Vitamin K Derivatives with Anti-SARS-CoV-2 Activity
Exploring Novel Vitamin K Derivatives with Anti-SARS-CoV-2 Activity Open
From our compound library of vitamin K derivatives, we found that some compounds exhibited anti-SARS-CoV-2 activity in VeroE6/TMPRSS2 cells. The common structure of these compounds was menaquinone-2 (MK-2) with either the m-methylphenyl or…
View article: Effect of increased saliva secretion on chewing and swallowing behaviors
Effect of increased saliva secretion on chewing and swallowing behaviors Open
I．目的
View article: Novel RT-PCR Using Sugar Chain-Immobilized Gold-Nanoparticles Correlates Patients’ Symptoms: The Follow-Up Study of COVID-19 Hospitalized Patients
Novel RT-PCR Using Sugar Chain-Immobilized Gold-Nanoparticles Correlates Patients’ Symptoms: The Follow-Up Study of COVID-19 Hospitalized Patients Open
Background: The transmissible capacity and toxicity of SARS-CoV-2 variants are continually changing. We report here the follow-up study of hospitalized COVID-19 patients from 2020 to 2022. It is known that the PCR diagnosis for hospitalize…
View article: Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action
Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action Open
Novel neplanocin A derivatives have been identified as potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro . These include (1S,2R,5R)-5-(5-bromo-4-methyl-7H-pyrrolo[2,3-d]-pyrimidin-7-yl)-3-(hydroxymethyl)cyclop…
View article: Novel Anti-CD70 Antibody Drug Conjugate for the Treatment of Adult T-Cell Leukemia (ATL)
Novel Anti-CD70 Antibody Drug Conjugate for the Treatment of Adult T-Cell Leukemia (ATL) Open
The anti-CD70 ADC offers some chemotherapeutic potential for the treatment of ATL.
View article: Synthesis and anti-HBV activity of carbocyclic nucleoside hybrids with salient features of entecavir and aristeromycin
Synthesis and anti-HBV activity of carbocyclic nucleoside hybrids with salient features of entecavir and aristeromycin Open
A new carbocyclic nucleoside with the salient features of entecavir and aristeromycin identified as the anti-HBV lead candidate.
View article: Synthesis, Anti-HBV, and Anti-HIV Activities of 3′-Halogenated Bis(hydroxymethyl)-cyclopentenyladenines
Synthesis, Anti-HBV, and Anti-HIV Activities of 3′-Halogenated Bis(hydroxymethyl)-cyclopentenyladenines Open
Synthesis of 3'-halogeno analogues (5a-d) of 9-[c-4,t-5-bis(hydroxymethyl)-cyclopent-2-en-r-1-yl]-9H-adenine (BCA, 3) was accomplished by means of dual utilization of the vinyl sulfone functional moieties in both 10 and 16 utilizing a SN2'…
View article: Effects of the Chemical Structures of Oligoarginines Conjugated to Biocompatible Polymers as a Mucosal Adjuvant on Antibody Induction in Nasal Cavities
Effects of the Chemical Structures of Oligoarginines Conjugated to Biocompatible Polymers as a Mucosal Adjuvant on Antibody Induction in Nasal Cavities Open
We have been investigating the potential of oligoarginine-linked polymers as an adjuvant for mucosal vaccination that induces immunoglobulin G (IgG) in systemic circulation and immunoglobulin A (IgA) secreted on the mucosa. Our latest infe…
View article: Establishment of an antiviral assay system and identification of severe fever with thrombocytopenia syndrome virus inhibitors
Establishment of an antiviral assay system and identification of severe fever with thrombocytopenia syndrome virus inhibitors Open
Aims Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease. SFTS is epidemic in Asia, and its fatality rate is around 30% in Japan. The causative virus severe fever with thrombocytopenia syndrome v…
View article: Immunomodulatory Potential of Herbal Formulations Containing Seeds of Nigella sativa Linn.
Immunomodulatory Potential of Herbal Formulations Containing Seeds of Nigella sativa Linn. Open
Immunostimulation counteracts immunosuppression, thereby playing a role in re-establishing body equilibrium. Plants with immunostimulatory activities are used as an alternative therapy for a variety of diseases, including impaired immune r…
View article: SELECTIVE INHIBITION OF HEPATITIS C VIRUS REPLICATION BY ALPHA-ZAM, A NIGELLA SATIVA SEED FORMULATION
SELECTIVE INHIBITION OF HEPATITIS C VIRUS REPLICATION BY ALPHA-ZAM, A NIGELLA SATIVA SEED FORMULATION Open
Background: Hepatitis C virus (HCV) infection became curable because of the development of direct acting antivirals (DAAs). However, the high cost of DAAs has greatly impeded their potential impact on the treatment of HCV infection. As a r…
View article: Synthesis, characterization, antimicrobial and antioxidant studies of 2-[(2-hydroxyphenyl) methylidene] hydrazine-1-carboxamide and its metal (ii) complexes
Synthesis, characterization, antimicrobial and antioxidant studies of 2-[(2-hydroxyphenyl) methylidene] hydrazine-1-carboxamide and its metal (ii) complexes Open
2-{(2-hydroxyphenyl) methylidene}hydrazine salicylaldehyde and semicarbazide.Its metal chlorides respectively.The compounds were characterized on the basis of solubility, melting point/decomposition temperature, magnetic susce sphectrophot…
View article: CCDC 971278: Experimental Crystal Structure Determination
CCDC 971278: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1479856: Experimental Crystal Structure Determination
CCDC 1479856: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Development of three-dimensional human skin models by cell coating technology for alternative systems to animal testing.
Development of three-dimensional human skin models by cell coating technology for alternative systems to animal testing. Open
Event Abstract Back to Event Development of three-dimensional human skin models by cell coating technology for alternative systems to animal testing. Takami Akagi1, 2, Mayuka Nagura1, 2, Ayami Hiura1, Tomoki Yano3, Michiya Matsusaki4, Sach…
View article: Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative
Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative Open
Background The novel phenanthridinone derivative HA-719 has recently been identified as a highly potent and selective inhibitor of hepatitis C virus replication. To elucidate its mechanism of inhibition, we have isolated and analyzed a clo…
View article: Identification of Antiviral Agents Targeting Hepatitis B Virus Promoter from Extracts of Indonesian Marine Organisms by a Novel Cell-Based Screening Assay
Identification of Antiviral Agents Targeting Hepatitis B Virus Promoter from Extracts of Indonesian Marine Organisms by a Novel Cell-Based Screening Assay Open
The current treatments of chronic hepatitis B (CHB) face a limited choice of vaccine, antibody and antiviral agents. The development of additional antiviral agents is still needed for improvement of CHB therapy. In this study, we establish…
View article: Incompatible Natures of the HIV-1 Envelope in Resistance to the CCR5 Antagonist Cenicriviroc and to Neutralizing Antibodies
Incompatible Natures of the HIV-1 Envelope in Resistance to the CCR5 Antagonist Cenicriviroc and to Neutralizing Antibodies Open
Cenicriviroc is a CCR5 antagonist which prevents human immunodeficiency virus type 1 (HIV-1) from cellular entry. The CCR5-binding regions of the HIV-1 envelope glycoprotein are important targets for neutralizing antibodies (NAbs), and mut…
View article: Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives
Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives Open
Background The reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) is an attractive target for the development of drugs used in the treatment of HIV-1 infection and acquired immune deficiency syndrome (AIDS). We have …
View article: Induction of Potent Adaptive Immunity by the Novel Polyion Complex Nanoparticles
Induction of Potent Adaptive Immunity by the Novel Polyion Complex Nanoparticles Open
The development of effective and simple methods of vaccine preparation is desired for the prophylaxis and treatment of a variety of infectious diseases and cancers. We have created novel polyion complex (PIC) nanoparticles (NPs) composed o…