Mark G. Baxter
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View article: Age, glucose tolerance, and cognitive performance in vervet monkeys
Age, glucose tolerance, and cognitive performance in vervet monkeys Open
Background Alzheimer's disease (AD) is the primary cause of dementia worldwide and is increasing in incidence. In humans, impaired glucose handling characteristic of pre‐ and type 2 diabetes (T2D) is associated with cognitive dysfunction a…
View article: Between-hospital variability in the management and outcomes of postoperative periprosthetic femoral fractures
Between-hospital variability in the management and outcomes of postoperative periprosthetic femoral fractures Open
Aims Postoperative periprosthetic femoral fractures (POPFFs) following hip arthroplasty pose complex challenges, with differences in management and outcomes across healthcare facilities. However, there is limited published literature on su…
View article: Optimized and Additively Manufactured Face Mills for Enhanced Cutting Performance
Optimized and Additively Manufactured Face Mills for Enhanced Cutting Performance Open
With the growing acceptance of additive manufacturing (AM) across various sectors, laser-based powder bed fusion (PBF-LB) has widely been utilized to create intricately shaped parts from a range of metals alloys. The factors contributing t…
View article: Locally Acquired (Autochthonous) Mosquito-Transmitted <i>Plasmodium vivax</i> Malaria — Saline County, Arkansas, September 2023
Locally Acquired (Autochthonous) Mosquito-Transmitted <i>Plasmodium vivax</i> Malaria — Saline County, Arkansas, September 2023 Open
A case of locally acquired (autochthonous) mosquito-transmitted Plasmodium vivax malaria was diagnosed in Arkansas in September 2023. This represents the 10th autochthonous case identified nationally in 2023, after 20 years without recorde…
View article: Brain Charts for the Rhesus Macaque Lifespan
Brain Charts for the Rhesus Macaque Lifespan Open
Recent efforts to chart human brain growth across the lifespan using large-scale MRI data have provided reference standards for human brain development. However, similar models for nonhuman primate (NHP) growth are lacking. The rhesus maca…
View article: Brain Charts for the Rhesus Macaque Lifespan
Brain Charts for the Rhesus Macaque Lifespan Open
Recent efforts to chart human brain growth across the lifespan using large-scale MRI data have provided reference standards for human brain development. However, similar models for nonhuman primate (NHP) growth are lacking. The rhesus maca…
View article: The hippocampus dissociates present from past and future goals
The hippocampus dissociates present from past and future goals Open
Our brain adeptly navigates goals across time frames, distinguishing between urgent needs and those of the past or future. The hippocampus is a region known for supporting mental time travel and organizing information along its longitudina…
View article: Relationships between AD‐related neuroanatomy and cognitive, physical, and social aging in vervet monkeys
Relationships between AD‐related neuroanatomy and cognitive, physical, and social aging in vervet monkeys Open
Background In humans, social integration wanes with age, a pattern hypothesized to stem from cognitive or physical decrements. Social isolation increases dementia risk. Nonhuman primates provide important translational opportunities to stu…
View article: Hippocampal timestamp for goals
Hippocampal timestamp for goals Open
Our brain must manage multiple goals that differ in their temporal proximity. Some goals require immediate attention, while others have already been accomplished, or will be relevant later in time. Here, we examined how the hippocampus rep…
View article: Neuropsychology of cognitive aging in rhesus monkeys
Neuropsychology of cognitive aging in rhesus monkeys Open
Aged rhesus monkeys, like aged humans, show declines in cognitive function. We present cognitive test data from a large sample of male and female rhesus monkeys, 34 young (aged 3.5-13.6 years) and 71 aged (aged 19.9-32.5 years at the start…
View article: Neuropsychology of cognitive aging in rhesus monkeys
Neuropsychology of cognitive aging in rhesus monkeys Open
Aged rhesus monkeys, like aged humans, show declines in cognitive function. We present cognitive test data from a large sample of male and female rhesus monkeys, 34 young (3.5-13.6 years) and 71 aged (19.9-32.5 years of age at the start of…
View article: Development of prefrontal corticostriatal connectivity in mice
Development of prefrontal corticostriatal connectivity in mice Open
Summary Rational decision making is grounded in learning to associate actions with outcomes, a process that depends on projections from prefrontal cortex to dorsomedial striatum. Symptoms associated with a variety of human pathological con…
View article: Neonatal exposures to sevoflurane in rhesus monkeys alter synaptic ultrastructure in later life
Neonatal exposures to sevoflurane in rhesus monkeys alter synaptic ultrastructure in later life Open
Repeated or prolonged early life exposure to anesthesia is neurotoxic in animals and associated with neurocognitive impairment in later life in humans. We used electron microscopy with unbiased stereological sampling to assess synaptic ult…
View article: Integrated Multi-Omics Analysis of Brain Aging in Female Nonhuman Primates Reveals Altered Signaling Pathways Relevant to Age-Related Disorders
Integrated Multi-Omics Analysis of Brain Aging in Female Nonhuman Primates Reveals Altered Signaling Pathways Relevant to Age-Related Disorders Open
The prefrontal cortex (PFC) has been implicated as a key brain region responsible for age-related cognitive decline. Little is known about aging-related molecular changes in PFC that may mediate these effects. To date, no studies have used…
View article: 1082 Pattern and outcomes of adolescent trauma in a mixed major trauma centre: a one-year review of TARN data
1082 Pattern and outcomes of adolescent trauma in a mixed major trauma centre: a one-year review of TARN data Open
Aims Trauma is the leading cause of death among young people [1 2]. The objective of this review is to outline main patterns of injury and related outcomes in this population and to describe the differences in presentations amongst younger…
View article: Ensemble remodeling supports memory-updating
Ensemble remodeling supports memory-updating Open
Memory-updating is critical in dynamic environments because updating memories with new information promotes versatility. However, little is known about how memories are updated with new information. To study how neuronal ensembles might su…
View article: A pragmatic reevaluation of the efficacy of nonhuman primate optogenetics for psychiatry
A pragmatic reevaluation of the efficacy of nonhuman primate optogenetics for psychiatry Open
Translational neuroscience is committed to generating discoveries in the laboratory that ultimately can improve human lives. Optogenetics has received considerable attention because of its demonstrated promise in rodent brains to manipulat…
View article: Neonatal exposures to sevoflurane in rhesus monkeys alter synaptic ultrastructure in later life
Neonatal exposures to sevoflurane in rhesus monkeys alter synaptic ultrastructure in later life Open
Early-life exposure to anesthesia in infant humans and monkeys increases the risk for cognitive and socioemotional impairments. However, the long-term effects of neonatal anesthesia on synaptic ultrastructure have not been thoroughly inves…
View article: Cognitive Deficits and Altered Cholinergic Innervation in Young Adult Mice Carrying a Parkinson’s Disease LRRK2-G2019S Knockin Mutation
Cognitive Deficits and Altered Cholinergic Innervation in Young Adult Mice Carrying a Parkinson’s Disease LRRK2-G2019S Knockin Mutation Open
Impaired executive function is a common and debilitating non-motor symptom of idiopathic and hereditary Parkinson’s disease (PD), but there is little understanding of the underlying pathophysiological mechanisms and circuits. The G2019S mu…