Michele Saviano
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View article: Structure-based identification of a non-covalent thioredoxin reductase inhibitor with proven ADMET suitability
Structure-based identification of a non-covalent thioredoxin reductase inhibitor with proven ADMET suitability Open
Thioredoxin reductase 1 (TrxR1), a selenoprotein enzyme crucial for redox homeostasis in mammals, has emerged as a promising target for anticancer therapy. In this study, we present a non-covalent TrxR1 inhibitor, identified through an int…
View article: Bioinspired RGD-Functionalized Gold Nanoparticles for Integrin-Driven Interaction with Melanoma Cells
Bioinspired RGD-Functionalized Gold Nanoparticles for Integrin-Driven Interaction with Melanoma Cells Open
This work provides new understanding of biomimetic gold nanoparticles and highlights their potential in tumour selective strategies, particularly for integring-targeted theranostics, while addressing toxicity and targeting limitations of c…
View article: Carbon Dots for Nucleic Acid-Based Diagnostics and Therapeutics: Focus on Oxidative DNA Damage
Carbon Dots for Nucleic Acid-Based Diagnostics and Therapeutics: Focus on Oxidative DNA Damage Open
Carbon dots (CDs) are gaining significant attention as multifunctional nanomaterials due to their optical properties, aqueous dispersibility, redox activity, and overall biocompatibility. This review presents a critical overview of the rec…
View article: Structural Implications of Missense Point Mutations in Shwachman–Bodian–Diamond Syndrome Protein (SBDS): A Combined SAXS/MD Investigation
Structural Implications of Missense Point Mutations in Shwachman–Bodian–Diamond Syndrome Protein (SBDS): A Combined SAXS/MD Investigation Open
Shwachman-Diamond syndrome (SDS) is a rare autosomal recessive disorder characterized by pleiotropic phenotypes, including pancreatic insufficiency, skeletal abnormalities, and bone marrow dysfunction. Notably, patients with SDS exhibit an…
View article: β‐Cyclodextrin Inclusion Complexes with Model Pentapeptides: Role of the Tyrosine Position within the Peptide Chain
β‐Cyclodextrin Inclusion Complexes with Model Pentapeptides: Role of the Tyrosine Position within the Peptide Chain Open
Peptide's applications frequently present problems of solubility, stability, activity, or membrane permeability. To overcome these issues, cyclodextrins (CDs) can be used to form inclusion complexes with peptide hydrophobic parts; alkyl‐ch…
View article: Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid
Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid Open
Peptide nucleic acids (PNAs) have garnered significant attention due to their enhanced chemical, physical, and binding properties in comparison to natural nucleic acids. This prompted their application in antigene/antisense approach, assig…
View article: Structural Insights Into Galectin‐3 Recognition of a Selenoglycomimetic
Structural Insights Into Galectin‐3 Recognition of a Selenoglycomimetic Open
Chimera‐type galectin‐3 (Gal‐3) is a β‐galactoside‐binding protein containing a single conserved carbohydrate‐recognition domain, crucial in fibrosis and carcinogenesis. Selenium‐based Gal‐3 inhibitors have emerged as promising therapeutic…
View article: Design, synthesis and evaluation of gluten peptide analogues as inhibitors of the HLA/DQ8-mediated celiac immune response
Design, synthesis and evaluation of gluten peptide analogues as inhibitors of the HLA/DQ8-mediated celiac immune response Open
New gluten peptide analogues were found by a comparative structural analysis of the peptide–protein interactions. A murine model allowed selecting those that inhibit the HLA/DQ8-mediated celiac immune response.
View article: Melleatin, an antibiofilm multitasking protein with rRNA N-glycosylase and nuclease activity from Armillaria mellea fruiting bodies
Melleatin, an antibiofilm multitasking protein with rRNA N-glycosylase and nuclease activity from Armillaria mellea fruiting bodies Open
Several studies highlight the identification of some enzymes with additional abilities, especially those involved in metabolic pathways and/or host defence processes, classified as multitasking proteins. In this context, we report the char…
View article: A CD Study of a Structure-Based Selection of N-Heterocyclic Bis-Carbene Gold(I) Complexes as Potential Ligands of the G-Quadruplex-Forming Human Telomeric hTel23 Sequence
A CD Study of a Structure-Based Selection of N-Heterocyclic Bis-Carbene Gold(I) Complexes as Potential Ligands of the G-Quadruplex-Forming Human Telomeric hTel23 Sequence Open
Herein, we report the structure-based selection via molecular docking of four N-heterocyclic bis-carbene gold(I) complexes, whose potential as ligands for the hTel23 G-quadruplex structure has been investigated using circular dichroism (CD…
View article: SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity prediction
SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity prediction Open
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19.
View article: Molecular interactions between a diphenyl scaffold and PED/PEA15: Implications for type II diabetes therapeutics targeting PED/PEA15 – Phospholipase D1 interaction
Molecular interactions between a diphenyl scaffold and PED/PEA15: Implications for type II diabetes therapeutics targeting PED/PEA15 – Phospholipase D1 interaction Open
In a recent study, we have identified BPH03 as a promising scaffold for the development of compounds aimed at modulating the interaction between PED/PEA15 (Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes 15) and P…
View article: Structure/function relationship of Atlantic bonito (Sarda sarda Bloch) myoglobin and comparison with Atlantic and Tinker mackerel myoglobins
Structure/function relationship of Atlantic bonito (Sarda sarda Bloch) myoglobin and comparison with Atlantic and Tinker mackerel myoglobins Open
Atlantic bonito meat has economic potential as an alternative to mackerel consumption. Thus, considering the presence of myoglobin (Mb) in red fish muscles, we report the characterisation of Atlantic bonito Mb compared to Atlantic and Tink…
View article: Spectroscopic study to assess the integrity of chemically modified curcumin: Hyaluronic acid-curcumin conjugate as a proof of the method
Spectroscopic study to assess the integrity of chemically modified curcumin: Hyaluronic acid-curcumin conjugate as a proof of the method Open
A hyaluronan-curcumin conjugate was synthesized by employing a green procedure, the final aim was to improve the aqueous solubility and the bioavailability of the curcumin by reducing its hydrolytic degradation. A comprehensive study on th…
View article: Microwave-Assisted, Solid-State Procedure to Covalently Conjugate Hyaluronic Acid to Curcumin: Validation of a Green Synthetic Protocol
Microwave-Assisted, Solid-State Procedure to Covalently Conjugate Hyaluronic Acid to Curcumin: Validation of a Green Synthetic Protocol Open
A microwave-assisted esterification reaction to prepare hyaluronan-curcumin derivatives by employing a solvent-free process was developed. In particular, a solid-state strategy to react two molecules characterized by totally different solu…
View article: Italian guidelines for the management of irritable bowel syndrome in children and adolescents
Italian guidelines for the management of irritable bowel syndrome in children and adolescents Open
The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still …
View article: Biophysical and Structural Characterization of the Interaction between Human Galectin-3 and the Lipopolysaccharide from Pseudomonas aeruginosa
Biophysical and Structural Characterization of the Interaction between Human Galectin-3 and the Lipopolysaccharide from Pseudomonas aeruginosa Open
Given the significant involvement of galectins in the development of numerous diseases, the aim of the following work is to further study the interaction between galectin-3 (Gal3) and the LPS from Pseudomonas aeruginosa. This manuscript fo…
View article: AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis Open
Drug-induced phospholipidosis (PLD) involves the accumulation of phospholipids in cells of multiple tissues, particularly within lysosomes, and it is associated with prolonged exposure to druglike compounds, predominantly cationic amphiphi…
View article: Advances in Nucleic Acid Research: Exploring the Potential of Oligonucleotides for Therapeutic Applications and Biological Studies
Advances in Nucleic Acid Research: Exploring the Potential of Oligonucleotides for Therapeutic Applications and Biological Studies Open
In recent years, nucleic acids have emerged as powerful biomaterials, revolutionizing the field of biomedicine. This review explores the multifaceted applications of nucleic acids, focusing on their pivotal role in various biomedical appli…
View article: Peptoids: Smart and Emerging Candidates for the Diagnosis of Cancer, Neurological and Autoimmune Disorders
Peptoids: Smart and Emerging Candidates for the Diagnosis of Cancer, Neurological and Autoimmune Disorders Open
Early detection of fatal and disabling diseases such as cancer, neurological and autoimmune dysfunctions is still desirable yet challenging to improve quality of life and longevity. Peptoids (N-substituted glycine oligomers) are a relative…
View article: The Biological Action and Structural Characterization of Eryngitin 3 and 4, Ribotoxin-like Proteins from Pleurotus eryngii Fruiting Bodies
The Biological Action and Structural Characterization of Eryngitin 3 and 4, Ribotoxin-like Proteins from Pleurotus eryngii Fruiting Bodies Open
Ribotoxin-like proteins (RL-Ps) are specific ribonucleases found in mushrooms that are able to cleave a single phosphodiester bond located in the sarcin–ricin loop (SRL) of the large rRNA. The cleaved SRL interacts differently with some ri…
View article: Disclosing the Preferential Mercury Chelation by SeCys Containing Peptides over Their Cys Analogues
Disclosing the Preferential Mercury Chelation by SeCys Containing Peptides over Their Cys Analogues Open
Methylmercury, mercury (II), and mercury (I) chlorides were found to react with vasopressin, a nonapeptide hormone cyclized by two cysteine residues, and its mono- and diselenium analogues to form several mercury-peptide adducts. The repla…
View article: Biological Action and Structural Characterization of Eryngitin 3 and 4, Ribotoxin-like Proteins from <em>Pleurotus eryngii</em> Fruiting Bodies
Biological Action and Structural Characterization of Eryngitin 3 and 4, Ribotoxin-like Proteins from <em>Pleurotus eryngii</em> Fruiting Bodies Open
Ribotoxin-like proteins (RL-Ps) are specific ribonucleases found in mushrooms that are able to cleave a single phosphodiester bond located in the Sarcin-Ricin Loop (SRL) of the large rRNA. The cleaved SRL interacts differently with some ri…
View article: GENERA: A Combined Genetic/Deep-Learning Algorithm for Multiobjective Target-Oriented De Novo Design
GENERA: A Combined Genetic/Deep-Learning Algorithm for Multiobjective Target-Oriented De Novo Design Open
This study introduces a new de novo design algorithm called GENERA that combines the capabilities of a deep-learning algorithm for automated drug-like analogue design, called DeLA-Drug, with a genetic algorithm for generating molecules wit…