Markus Bischoff
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View article: Tracheal tuft cell-released leukotrienes promote antibacterial immune responses
Tracheal tuft cell-released leukotrienes promote antibacterial immune responses Open
SUMMARY Tuft cells act as crucial sentinels in the airways that detect bacterial metabolites. In response, tuft cells release signaling molecules that trigger immune responses essential for clearing the infection. The molecular mechanisms …
Melanocyte differentiation and mechanosensation are differentially modulated by distinct extracellular matrix proteins Open
Melanocyte dysfunctions can lead to pigmentation disorders or melanoma. Melanocytes interact context-dependently with various types of ECM, including collagens and fibronectin. Alterations in ECM composition and stiffness can impact cell b…
<i>Staphylococcus aureus</i> Adhesion on Hydrophobin Coatings: Adhesion Forces and the Influence of Surface Charge Open
Staphylococcus aureus (S. aureus) is one of the bacterial species capable of forming multilayered biofilms on implants. Such biofilms formed on implanted medical devices often require the removal of the implant in order to avoid sepsis or,…
View article: Assessment of the biofilm formation capacities of Staphylococcus aureus strains Newman and Newman D2C in vitro and in vivo
Assessment of the biofilm formation capacities of Staphylococcus aureus strains Newman and Newman D2C in vitro and in vivo Open
Staphylococcus aureus is a major cause of implant-associated infections (IAIs). The ability of this Gram-positive bacterium to cause IAIs is closely related to its capacity to attach to and to form biofilms on the implant material. Biofilm…
View article: Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance
Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance Open
The benefit that antibiotics confer to the welfare of mankind is threatened by bacterial resistance. Resistance to daptomycin, a cyclic lipopeptide frequently used for the treatment of complicated bacteremia, is a prime example of this ala…
View article: Dipeptidic Phosphonates: Potent Inhibitors of <i>Pseudomonas aeruginosa</i> Elastase B Showing Efficacy in a Murine Keratitis Model
Dipeptidic Phosphonates: Potent Inhibitors of <i>Pseudomonas aeruginosa</i> Elastase B Showing Efficacy in a Murine Keratitis Model Open
The ubiquitous opportunistic pathogen Pseudomonas aeruginosa is responsible for severe infections and notoriously known for acquiring antimicrobial resistance. Inhibiting the bacterium's extracellular elastase, LasB – a zinc‐dependent prot…
Melanocyte differentiation and mechanosensation are differentially modulated by distinct extracellular matrix proteins Open
Dysfunctions in melanocytes can lead to pigmentation disorders, such as albinism, or contribute to the development of melanoma, the most aggressive form of skin cancer. Epidermal melanocytes typically interact with the collagen IV-rich bas…
Extracellular Release of a Disintegrin and Metalloproteinase Correlates With Periodontal Disease Severity Open
Aim Periodontal disease is driven by oral pathogens, including Porphyromonas gingivalis , and the release of inflammatory cytokines. These cytokines (e.g., TNF) or their receptors (e.g., IL‐1R) are substrates of a disintegrin and metallopr…
View article: Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application Open
The natural product chlorotonil displays high potency against multidrug‐resistant Gram‐positive bacteria and Plasmodium falciparum . Yet, its scaffold is characterized by low solubility and oral bioavailability, but progress was recently m…
Characterization of a unique attachment organelle: Single-cell force spectroscopy of <i>Giardia duodenalis</i> trophozoites Open
FluidFM-based detachment of single Giardia duodenalis trophozoites from a flat glass surface revealed a unique detachment characteristic and adhesion mode for this type of parasite, compared to yeast cells or human keratinocytes.
View article: CCDC 2259874: Experimental Crystal Structure Determination
CCDC 2259874: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Chalcogen-Varied Imidazolone Derivatives as Antibiotic Resistance Breakers in Staphylococcus aureus Strains
Chalcogen-Varied Imidazolone Derivatives as Antibiotic Resistance Breakers in Staphylococcus aureus Strains Open
In this study, a search for new therapeutic agents that may improve the antibacterial activity of conventional antibiotics and help to successfully overcome methicillin-resistant Staphylococcus aureus (MRSA) infections has been conducted. …
The adhesion capability of<i>Staphylococcus aureus</i>cells is heterogeneously distributed over the cell envelope Open
By experiments and simulations on structured surfaces, we show that S. aureus cells have adhesive patches that are heterogeneously distributed across the cell envelope.
The secreted tyrosine phosphatase PtpA promotes <i>Staphylococcus aureus</i> survival in RAW 264.7 macrophages through decrease of the SUMOylation host response Open
Staphylococcus aureus is a human pathogen that is extremely adaptable and is the cause of a variety of nosocomial and community-acquired infectious diseases. During infection, S. aureus is able to affect the host cell in many ways to enabl…
View article: CCDC 2129280: Experimental Crystal Structure Determination
CCDC 2129280: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2129279: Experimental Crystal Structure Determination
CCDC 2129279: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2129277: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2129276: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2129278: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Extracellular release of a disintegrin and metalloproteinases orchestrates periodontal disease severity Open
Periodontal diseases are amongst the most common pathologies worldwide with a high risk for the development of systemic complications. Periodontal disease is driven by oral pathogens such as Porphyromonas gingivalis and the release of infl…
View article: Data from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth
Data from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth Open
Transient induction of the transcription factor early growth response protein-1 (EGR-1) plays a pivotal role in the transcriptional response of endothelial cells to the angiogenic growth factors vascular endothelial growth factor (VEGF) an…
Protein Disulfide Isomerase and Extracellular Adherence Protein Cooperatively Potentiate Staphylococcal Invasion into Endothelial Cells Open
Staphylococcus aureus can invade and persist in non-professional phagocytes, thereby escaping host defense mechanisms and antibiotic treatment. The intracellular lifestyle of S. aureus contributes to the development of infection, e.g., in …
View article: Supplementary Tables S1 & S2 from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth
Supplementary Tables S1 & S2 from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth Open
Supplementary Tables S1 & S2 from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth
View article: Supplementary Tables S1 & S2 from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth
Supplementary Tables S1 & S2 from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth Open
Supplementary Tables S1 & S2 from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth
View article: Data from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth
Data from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth Open
Transient induction of the transcription factor early growth response protein-1 (EGR-1) plays a pivotal role in the transcriptional response of endothelial cells to the angiogenic growth factors vascular endothelial growth factor (VEGF) an…
Protein disulfide isomerase and extracellular adherence protein (Eap) cooperatively potentiate staphylococcal invasion into endothelial cells Open
This data file contains images from Western blots and raw data used for the manuscript "Protein disulfide isomerase and extracellular adherence protein (Eap) cooperatively potentiate staphylococcal invasion into endothelial cells"
View article: Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions
Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions Open
Atherosclerosis is a chronic, inflammatory disease of the vessel wall where triggered immune cells bind to inflamed endothelium, extravasate and sustain local inflammation. Leukocyte adhesion and extravasation are mediated by adhesion mole…