Anna M. Blom
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View article: Early Postreperfusion Proteomics Reveal Divergent Inflammatory Responses in Kidney Transplantation with Implications on Outcomes
Early Postreperfusion Proteomics Reveal Divergent Inflammatory Responses in Kidney Transplantation with Implications on Outcomes Open
Background. Ischemia/reperfusion injury is an unavoidable consequence of kidney transplantation, yet the characteristics of the immediate immune response after reperfusion and its impact on transplant outcomes remain poorly characterized i…
View article: Complement at the crossroads of inflammation and metabolism: implications for diabetes and metabolic functions
Complement at the crossroads of inflammation and metabolism: implications for diabetes and metabolic functions Open
Diabetes is a growing global problem, with hundreds of millions of people living with the disease worldwide. Diabetes can be divided into two major subtypes, autoimmune type 1 diabetes (T1D), and type 2 diabetes (T2D), which has stronger c…
View article: Comparative infectivity, virulence and molecular epidemiology of MDR and XDR Acinetobacter baumannii isolates emerging from war-related injuries in Ukraine
Comparative infectivity, virulence and molecular epidemiology of MDR and XDR Acinetobacter baumannii isolates emerging from war-related injuries in Ukraine Open
We report the first results characterizing the pathogenesis and infectivity of the emerging A. baumannii ST19. High MDR and XDR rates alongside clonally related isolates are concerning and highlight the importance of infection prevention a…
View article: Plasma C4d levels correlate with treatment response and renal activity in proliferative lupus nephritis
Plasma C4d levels correlate with treatment response and renal activity in proliferative lupus nephritis Open
Objective The investigation of complement factors in lupus nephritis (LN) in relation to treatment response and the impact of underlying genetics of C4. Methods Seventy-seven patients with active LN confirmed by a kidney biopsy and in whom…
View article: Acinetobacter baumannii Clinical Isolates Resist Complement-Mediated Lysis by Inhibiting the Complement Cascade and Improperly Depositing MAC
Acinetobacter baumannii Clinical Isolates Resist Complement-Mediated Lysis by Inhibiting the Complement Cascade and Improperly Depositing MAC Open
Introduction: Acinetobacter baumannii is a gram-negative opportunistic bacterium that causes life-threatening infections in immunocompromised hosts. The complement system is a critical mechanism of innate immunity that protects the human b…
View article: Supplementary Figure 6 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Supplementary Figure 6 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
Supplementary figure 6. FH expression in glioma correlates with pro-tumorigenic markers
View article: Figure 6 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Figure 6 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
FH is expressed in human glioma and correlates with disease severity. FH is produced in human lower-grade glioma (A) and GBM (B). C, FH expression correlates with decreased overall survival (C) and disease-free survival (D) of patients wit…
View article: Supplementary Figure 5 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Supplementary Figure 5 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
Supplementary figure 5. FH, ICOSL and ICOS dependence on glioma patient survival. The survival data of n = 509 patients from TCGA provisional dataset brain lower-grade glioma, analyzed with cBioPortal. Statistical tests: Logrank Test.
View article: Supplementary Figure 2 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Supplementary Figure 2 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
Supplementary figure 2. FH in Ntv-a mouse model (A) Mouse FH binds to mouse derived primary Tregs. Tregs were incubated for 2 h at 4oC with fluorescently labeled 25 or 100 μg/mL FH. The binding was detected using flow cytometry. (B) Wester…
View article: Supplementary Figure 3 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Supplementary Figure 3 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
Supplementary figure 3. Direct effect of FH on glioma cells Proliferation of PIGPC cells treated with medium only, 25- or 100-μg/mL FH (A) and H4 mock or FH-transfected (B) was analyzed after 24, 48, 72 and 96 hours using CyQUANT assay. Da…
View article: Data from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Data from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
The survival rate of patients with glioma has not significantly increased in recent years despite aggressive treatment and advances in immunotherapy. The limited response to treatments is partially attributed to the immunosuppressive tumor…
View article: Figure 4 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Figure 4 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
FH knockdown is associated with a lower number of ICOS+ Tregs in a murine glioma model. FH expression was investigated in murine gliomas generated using the RCAS/tv-a vectors to induce expression of PDGFB (A and B) and shp53 (B). C, Schema…
View article: Supplementary Figure 4 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Supplementary Figure 4 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
Supplementary figure 4. Staining control for human samples and additional information about patients (A) Histology and (B) clinical parameters of glioma patients. MGMT-methylation status; TMZ-temozolomide; Adj-adjusted. WT – wild type.
View article: Figure 1 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Figure 1 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
FH binds to T cells via ICOS. A, Biotinylated FH binds to CD4+ T cells upon incubation for 2 hours with TexMACS medium alone and supplemented with 50 and 100 μg/mL FH. B, Fractionation detecting FH binding but not internalization into CD4+…
View article: Figure 3 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Figure 3 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
FH enhances the immunosuppressive function of Tregs. A, FH increases the immunosuppressive effect of Tregs. Tregs were incubated in medium only or supplemented with 150 μg/mL FH. CD4+ T cells were isolated from the same donor and coculture…
View article: Figure 5 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Figure 5 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
ICOS is associated with poor prognosis of patients with glioma. A, ICOS expression correlates with decreased survival of patients with glioma. Expression of ICOS correlates with neoplasm histological grade (B), cancer type (C), and EGFR mu…
View article: Figure 7 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Figure 7 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
FH in glioma correlates with Treg occurrence and increased Treg viability. FH expression positively correlates with infiltration of Tregs in lower-grade glioma (A) and GBM (B). C, Western blot detecting FH in supernatants of FH-transfected…
View article: Figure 2 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Figure 2 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
FH increases the viability of Tregs. FH-rendered increase in survival of CD4+ (A) but not CD8+ (B) or naïve CD4+ (C) T cells. FH increased survival of Tregs (D) and did not increase survival of Treg-depleted CD4+ T cells (E). Cells were in…
View article: Supplementary Figure 1 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Supplementary Figure 1 from Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment Open
Supplementary figure 1. FH binds to T-cells via ICOS
View article: Complement factors as biomarkers in ANCA-associated vasculitis in remission
Complement factors as biomarkers in ANCA-associated vasculitis in remission Open
Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of rare, autoimmune diseases causing inflammation in the vessel wall. Many organs can be affected, and kidney involvement is a common and serious…
View article: <scp>CD59</scp> double knockout mice express a <scp>CD59ba</scp> hybrid fusion protein that mediates insulin secretion
<span>CD59</span> double knockout mice express a <span>CD59ba</span> hybrid fusion protein that mediates insulin secretion Open
CD59 is a cell‐surface inhibitor of the terminal step in the complement cascade. However, in addition to its complement inhibitory function, a non‐canonical role of CD59 in pancreatic beta cells has been identified. Two recently discovered…
View article: Shedding of membrane complement inhibitors CD59 and CD46 into the circulation is associated with poor prognosis in acute coronary syndrome patients: a cohort study
Shedding of membrane complement inhibitors CD59 and CD46 into the circulation is associated with poor prognosis in acute coronary syndrome patients: a cohort study Open
Introduction The role of the complement inhibitory proteins CD46 and CD59 in the immune response to an acute coronary syndrome (ACS) is unknown. We investigated the relationships between the shedding of CD46 and CD59 into the circulation, …