Braden Kuo
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View article: Insights Into Functional Dyspepsia and Gastroparesis – Western Versus Asian Perspectives
Insights Into Functional Dyspepsia and Gastroparesis – Western Versus Asian Perspectives Open
Functional dyspepsia and gastroparesis are common gastrointestinal conditions that can significantly impact a patient's quality of life. Management of these conditions can be challenging for the treating physician due to overlap in symptom…
View article: Transcutaneous auricular vagus nerve stimulation for functional dyspepsia: A systematic review and meta-analysis
Transcutaneous auricular vagus nerve stimulation for functional dyspepsia: A systematic review and meta-analysis Open
Considering the certainty of the evidence, taVNS can improve dyspepsia symptoms, quality of life, anxiety, and depression in patients with FD without serious adverse events. Additional high-quality studies are needed to establish optimal t…
View article: Food Insecurity and Gastrointestinal Health: Examining Links Between Food Security, Constipation, and Diarrhea in the National Health and Nutrition Examination Survey
Food Insecurity and Gastrointestinal Health: Examining Links Between Food Security, Constipation, and Diarrhea in the National Health and Nutrition Examination Survey Open
Purpose Food insecurity impacts health in a multifactorial fashion, but the relationship with bowel habits is poorly understood. We aimed to examine the association between food insecurity status and bowel habits in a large cohort of U.S. …
View article: Relationship Between Hemoglobin A1c and Fecal Incontinence in a Nationwide Cohort Study
Relationship Between Hemoglobin A1c and Fecal Incontinence in a Nationwide Cohort Study Open
Introduction Gastrointestinal manifestations of diabetes include a variety of symptoms, including fecal incontinence (FI). We investigated the relationship between hemoglobin A1c and FI among US adults in a large, population‐based survey. …
View article: Current Concepts in Gastroparesis and Gastric Neuromuscular Disorders—Pathophysiology, Diagnosis, and Management
Current Concepts in Gastroparesis and Gastric Neuromuscular Disorders—Pathophysiology, Diagnosis, and Management Open
Upper gastrointestinal concerns including gastroparesis-like symptoms affect a large portion of the population, and determining the culprit condition can be difficult due to largely shared symptoms, clinical course, pathophysiology, and tr…
View article: Impact of Constipation Therapies on Severity of Gastroparesis and Constipation Symptoms in Relation to Gastric and Colonic Transit
Impact of Constipation Therapies on Severity of Gastroparesis and Constipation Symptoms in Relation to Gastric and Colonic Transit Open
Introduction Studies demonstrate an overlap of constipation with gastroparesis and functional dyspepsia, but the impact of treatments that target constipation on improving upper gastrointestinal (UGI) symptoms is unexplored. We quantified …
View article: The Assessment of Gastrointestinal Transit by the Atmo Capsule: A Comparison With the SmartPill Capsule
The Assessment of Gastrointestinal Transit by the Atmo Capsule: A Comparison With the SmartPill Capsule Open
gov number, NCT05718505.
View article: Bilingual Perspectives of Functional Dyspepsia Management in People From Underserved Areas
Bilingual Perspectives of Functional Dyspepsia Management in People From Underserved Areas Open
INTRODUCTION: Disorders of gut-brain interaction, such as functional dyspepsia (FD), are prevalent and challenging conditions. In other gastrointestinal (GI) disorders, individuals from underserved areas (UAs) have difficulty accessing car…
View article: Future Applications of Central Neuromodulation and Neurophysiological Testing in Cyclic Vomiting Syndrome
Future Applications of Central Neuromodulation and Neurophysiological Testing in Cyclic Vomiting Syndrome Open
Background Cyclic vomiting syndrome (CVS) is defined by its episodic patterning. Furthermore, CVS is associated with other episodic disorders such as migraine and epilepsy. Indeed, many of the medications that are known to be useful for pr…
View article: Altered parasympathetic outflow and central sensitization response to continuous pain in cyclic vomiting syndrome: a functional magnetic resonance imaging study
Altered parasympathetic outflow and central sensitization response to continuous pain in cyclic vomiting syndrome: a functional magnetic resonance imaging study Open
Patients with cyclic vomiting syndrome exhibit multiple alterations in central function in response to a sustained pressure-pain stimulus, including altered high-frequency heart rate variability and associated changes in BOLD fMRI signal i…
View article: The American Neurogastroenterology and Motility Society Gastroparesis Cardinal Symptom Index‐Daily Diary (<scp>ANMS GCSI</scp>‐<scp>DD</scp>): Psychometric validation and meaningful change threshold in patients with idiopathic or diabetic gastroparesis
The American Neurogastroenterology and Motility Society Gastroparesis Cardinal Symptom Index‐Daily Diary (<span>ANMS GCSI</span>‐<span>DD</span>): Psychometric validation and meaningful change threshold in patients with idiopathic or diabetic gastroparesis Open
Introduction The American Neurogastroenterology and Motility Society Gastroparesis Cardinal Symptom Index‐Daily Diary (ANMS GCSI‐DD) is a patient‐reported outcome (PRO) instrument for gastroparesis. This study evaluated the psychometric pr…
View article: Metagenomics Analysis Reveals Unique Gut Microbiota Signature of Slow-Transit Constipation
Metagenomics Analysis Reveals Unique Gut Microbiota Signature of Slow-Transit Constipation Open
INTRODUCTION: Altered gut microbiota may play a role in slow-transit constipation (STC). We conducted a study of gut microbiota composition and functionality in STC using metagenomic analyses. METHODS: We assembled a clinical cohort of 24 …
View article: Transitions of care for adolescents with disorders of gut–brain interaction
Transitions of care for adolescents with disorders of gut–brain interaction Open
Objectives Little is known about the experience of adolescents and young adults (AYA) with disorders of gut–brain interaction (DGBI) who transition from pediatric to adult gastroenterology care. In this two‐part study, we used quantitative…
View article: Maladaptive weight control and eating behaviours in female adolescents/young adults are associated with increased risk of irritable bowel syndrome in adulthood: Results from the Growing Up Today Study (GUTS)
Maladaptive weight control and eating behaviours in female adolescents/young adults are associated with increased risk of irritable bowel syndrome in adulthood: Results from the Growing Up Today Study (GUTS) Open
Summary Background Irritable bowel syndrome (IBS) is common among individuals with eating disorders. The relationship between these conditions is likely bidirectional. However, data on the risk of IBS among those with prior eating disorder…
View article: Predicting Response to Neuromodulators or Prokinetics in Patients With Suspected Gastroparesis Using Machine Learning: The “BMI, Infectious Prodrome, Delayed GES, and No Diabetes” Model
Predicting Response to Neuromodulators or Prokinetics in Patients With Suspected Gastroparesis Using Machine Learning: The “BMI, Infectious Prodrome, Delayed GES, and No Diabetes” Model Open
INTRODUCTION: Pharmacologic therapies for symptoms of gastroparesis (GP) have limited efficacy, and it is difficult to predict which patients will respond. In this study, we implemented a machine learning model to predict the response to p…
View article: Electroceuticals and Magnetoceuticals in Gastroenterology
Electroceuticals and Magnetoceuticals in Gastroenterology Open
In the realm of gastroenterology, the inadequacy of current medical treatments for gastrointestinal (GI) motility disorders and inflammatory bowel disease (IBD), coupled with their potential side effects, necessitates novel therapeutic app…
View article: Low Vitamin D Levels in Patients with Symptoms of Gastroparesis: Relationships with Nausea and Vomiting, Gastric Emptying and Gastric Myoelectrical Activity
Low Vitamin D Levels in Patients with Symptoms of Gastroparesis: Relationships with Nausea and Vomiting, Gastric Emptying and Gastric Myoelectrical Activity Open
Low vitamin D levels are present in half the patients with symptoms of gastroparesis and are associated with nausea and vomiting and gastric neuromuscular dysfunction.
View article: Large-Caliber Empiric Esophageal Dilation Results in Sustained Improvement for Selected Patients With Nonobstructive Dysphagia
Large-Caliber Empiric Esophageal Dilation Results in Sustained Improvement for Selected Patients With Nonobstructive Dysphagia Open
INTRODUCTION: Empiric esophageal dilation (EED) remains a controversial practice for managing nonobstructive dysphagia (NOD) secondary to concerns about safety and efficacy. We examine symptom response, presence of tissue disruption, and a…
View article: Single cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis
Single cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis Open
Gastrointestinal immune cells, particularly muscularis macrophages (MM) interact with the enteric nervous system and influence gastrointestinal motility. Here we determine the human gastric muscle immunome and its changes in patients with …
View article: Management of Gastrointestinal Symptoms in Parkinson’s Disease
Management of Gastrointestinal Symptoms in Parkinson’s Disease Open
Gastrointestinal symptoms in Parkinson’s disease (PD) are among the most prevalent and debilitating of complications and present unique diagnostic and management challenges. Patients with PD commonly experience dysphagia, nausea, bloating,…
View article: Influence of patient-clinician relationship style on acupuncture outcomes in functional dyspepsia: A multi-site randomized controlled trial in Korea
Influence of patient-clinician relationship style on acupuncture outcomes in functional dyspepsia: A multi-site randomized controlled trial in Korea Open
Clinicians should consider cultural differences when applying acupuncture therapy.
View article: Safety of Pneumatic Dilation in Older Adults with Achalasia: An International Multicenter Cross-Sectional Study
Safety of Pneumatic Dilation in Older Adults with Achalasia: An International Multicenter Cross-Sectional Study Open
Background: Pneumatic dilation (PD) is an effective first line treatment option for many patients with achalasia. PD use may be limited in adults with achalasia who are older than 65 because of concern for adverse events (AE), and less eff…
View article: A pilot genome‐wide association study meta‐analysis of gastroparesis
A pilot genome‐wide association study meta‐analysis of gastroparesis Open
Background Gastroparesis (GP) is characterized by delayed gastric emptying in the absence of mechanical obstruction. Objective Genetic predisposition may play a role; however, investigation at the genome‐wide level has not been performed. …
View article: Gastrointestinal Sensory Neuropathy and Dysmotility in Fabry Disease: Presentations and Effect on Patient's Quality of Life
Gastrointestinal Sensory Neuropathy and Dysmotility in Fabry Disease: Presentations and Effect on Patient's Quality of Life Open
INTRODUCTION: Fabry disease is a rare multisystemic lysosomal disease resulting in variable manifestations of the gastrointestinal (GI), neurologic, cardiac, and renal systems. Whether GI manifestations are a result of gut dysmotility is u…