Tina M. Briere
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View article: Optimizing Motion Management and Baseline Shifts in Magnetic Resonance-Guided Spine Stereotactic Body Radiation Therapy
Optimizing Motion Management and Baseline Shifts in Magnetic Resonance-Guided Spine Stereotactic Body Radiation Therapy Open
Background: Stereotactic body radiation therapy (SBRT) has proven effective in controlling spinal lesions with minimal toxicity, primarily due to its ability to limit spinal cord dose. Recent advances in MR-linac (MRL) technology offer sup…
View article: Therapy, Safety, and Logistics of Preoperative vs Postoperative Stereotactic Radiation Therapy
Therapy, Safety, and Logistics of Preoperative vs Postoperative Stereotactic Radiation Therapy Open
Importance Preoperative stereotactic radiation therapy (SRT) vs postoperative SRT logistics and toxic effects provides clinically significant data on management outcomes. Objective To determine preoperative SRT logistics and safety profile…
View article: Advanced External Beam Stereotactic Radiotherapy for Skull Base Reirradiation
Advanced External Beam Stereotactic Radiotherapy for Skull Base Reirradiation Open
Background/Objectives: Stereotactic body radiation therapy (SBRT) for skull base reirradiation is particularly challenging, as patients have already received substantial radiation doses to the region, and nearby normal organs may have appr…
View article: OS05.5.A DOSE ESCALATED SPINE RADIOSURGERY FOR RADIORESISTANT SPINAL METASTASES UTILIZING SIMULTANEOUS INTEGRATED BOOST
OS05.5.A DOSE ESCALATED SPINE RADIOSURGERY FOR RADIORESISTANT SPINAL METASTASES UTILIZING SIMULTANEOUS INTEGRATED BOOST Open
BACKGROUND Spine stereotactic body radiosurgery (SSRS) delivers ablative doses of radiation with sub-millimeter precision leading to high rates of local control with minimal toxicity. Treatment dose, fractionation and technique vary from i…
View article: Automatic end‐to‐end VMAT treatment planning for rectal cancers
Automatic end‐to‐end VMAT treatment planning for rectal cancers Open
Background The treatment planning process from segmentation to producing a deliverable plan is time‐consuming and labor‐intensive. Existing solutions automate the segmentation and planning processes individually. The feasibility of combini…
View article: CTNI-01. LONG-TERM RESULTS FROM A PHASE 1 TRIAL OF SPINE SBRT IN INOPERABLE PATIENTS WITH CORD COMPRESSION
CTNI-01. LONG-TERM RESULTS FROM A PHASE 1 TRIAL OF SPINE SBRT IN INOPERABLE PATIENTS WITH CORD COMPRESSION Open
PURPOSE/OBJECTIVE We seek to establish the feasibility of using spine stereotactic radiosurgery (SSRS) allowing for spinal cord dose constraint relaxation as the primary management of metastatic epidural spinal cord compression (MESCC) in …
View article: Response of Treatment-Naive Brain Metastases to Stereotactic Radiosurgery
Response of Treatment-Naive Brain Metastases to Stereotactic Radiosurgery Open
With improvements in survival for patients with metastatic cancer, long-term local control of brain metastases has become an increasingly important clinical priority. While consensus guidelines recommend surgery followed by stereotactic ra…
View article: Nivolumab and ipilimumab with concurrent stereotactic radiosurgery for intracranial metastases from non-small cell lung cancer: analysis of the safety cohort for non-randomized, open-label, phase I/II trial
Nivolumab and ipilimumab with concurrent stereotactic radiosurgery for intracranial metastases from non-small cell lung cancer: analysis of the safety cohort for non-randomized, open-label, phase I/II trial Open
Background Up to 20% of patients with non-small cell lung cancer (NSCLC) develop brain metastasis (BM), for which the current standard of care is radiation therapy with or without surgery. There are no prospective data on the safety of ste…
View article: Safety and efficacy of salvage conventional re-irradiation following stereotactic radiosurgery for spine metastases
Safety and efficacy of salvage conventional re-irradiation following stereotactic radiosurgery for spine metastases Open
Purpose: There has been limited work assessing the use of re-irradiation (re-RT) for local failure following stereotactic spinal radiosurgery (SSRS). We reviewed our institutional experience of conventionally-fractionated external beam rad…
Deep Learning for Detecting Brain Metastases on MRI: A Systematic Review and Meta-Analysis Open
Since manual detection of brain metastases (BMs) is time consuming, studies have been conducted to automate this process using deep learning. The purpose of this study was to conduct a systematic review and meta-analysis of the performance…
Automated field‐in‐field whole brain radiotherapy planning Open
Purpose We developed and tested an automatic field‐in‐field (FIF) solution for whole‐brain radiotherapy (WBRT) planning that creates a homogeneous dose distribution by minimizing hotspots, resulting in clinically acceptable plans. Methods …
Comparison of setup accuracy and efficiency between the Klarity system and BodyFIX system for spine stereotactic body radiation therapy Open
Background Spine stereotactic body radiation therapy (SBRT) uses highly conformal dose distributions and sharp dose gradients to cover targets in proximity to the spinal cord or cauda equina, which requires precise patient positioning and …
Dosimetric analysis of MR‐LINAC treatment plans for salvage spine SBRT re‐irradiation Open
Purpose We investigated the feasibility of thoracic spine stereotactic body radiotherapy (SBRT) using the Elekta Unity magnetic resonance‐guided linear accelerator (MRL) in patients who received prior radiotherapy. We hypothesized that Mon…
Automation of radiation treatment planning for rectal cancer Open
Purpose To develop an automated workflow for rectal cancer three‐dimensional conformal radiotherapy (3DCRT) treatment planning that combines deep learning (DL) aperture predictions and forward‐planning algorithms. Methods We designed an al…
View article: RONC-06. Stereotactic radiosurgery and stereotactic radiotherapy for pediatric brain metastases or recurrences
RONC-06. Stereotactic radiosurgery and stereotactic radiotherapy for pediatric brain metastases or recurrences Open
BACKGROUND/PURPOSE: Stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) deliver highly conformal, ablative doses of radiation over 1–5 treatments, while minimizing dose to surrounding normal tissues. To document toxicities …
Brain stereotactic radiosurgery using MR‐guided online adaptive planning for daily setup variation: An end‐to‐end test Open
Online magnetic resonance (MR)‐guided radiotherapy is expected to benefit brain stereotactic radiosurgery (SRS) due to superior soft tissue contrast and capability of daily adaptive planning. The purpose of this study was to investigate da…
CTNI-44. DOSIMETRIC IMPACT OF TUMOR TREATING FIELDS ON CONCURRENT RADIATION THERAPY FOR PEDIATRIC BRAIN TUMORS Open
INTRODUCTION Early results suggest that tumor treating fields (TTF) concurrent with radiotherapy (RT) for glioblastoma yields acceptable dosimetry in adults; the impact on RT dose distribution in children is unknown. This study was underta…
RADI-18. Survival and disease control after upfront stereotactic radiosurgery for brain metastases from breast cancer Open
Background As systemic therapy for metastatic breast cancer (BC) improves, the survival benefit from hormonal and targeted therapy urges treatment of brain metastases (BMs) with minimal toxicity and less systemic therapy interruption. Here…
View article: Clinical implementation of automated treatment planning for whole‐brain radiotherapy
Clinical implementation of automated treatment planning for whole‐brain radiotherapy Open
The purpose of the study was to develop and clinically deploy an automated, deep learning‐based approach to treatment planning for whole‐brain radiotherapy (WBRT). We collected CT images and radiotherapy treatment plans to automate a beam …
Early and Midtreatment Mortality in Palliative Radiotherapy: Emphasizing Patient Selection in High-Quality End-of-Life Care Open
Background: Palliative radiotherapy (RT) is effective, but some patients die during treatment or too soon afterward to experience benefit. This study investigates end-of-life RT patterns to inform shared decision-making and facilitate trea…