Matthew A. Brown
YOU?
Author Swipe
View article: Common and rare variant analyses reveal genetic factors underlying idiopathic pulmonary fibrosis and its shared aetiology with severe COVID-19
Common and rare variant analyses reveal genetic factors underlying idiopathic pulmonary fibrosis and its shared aetiology with severe COVID-19 Open
None.
View article: Clinical potential of whole-genome data linked to mortality statistics in patients with breast cancer in the UK: a retrospective analysis
Clinical potential of whole-genome data linked to mortality statistics in patients with breast cancer in the UK: a retrospective analysis Open
National Institute of Health Research, Breast Cancer Research Foundation, Dr Josef Steiner Cancer Research Award 2019, Basser Gray Prime Award 2020, Cancer Research UK, Sir Jeffrey Cheah Early Career Fellowship, the Mats Paulsson Foundatio…
View article: Medical guidelines for fibrodysplasia ossificans progressiva
Medical guidelines for fibrodysplasia ossificans progressiva Open
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic condition characterized by congenital malformations of the great toes and progressive heterotopic ossification (HO) in specific anatomic patterns. Present management summ…
View article: Further Evidence That Chondrocalcinosis 1 ( <scp>CCAL1</scp> ) is a Confirmed Mendelian Phenotype With a Known Molecular Basis
Further Evidence That Chondrocalcinosis 1 ( <span>CCAL1</span> ) is a Confirmed Mendelian Phenotype With a Known Molecular Basis Open
Chondrocalcinosis (CCAL), also known as calcium pyrophosphate dihydrate deposition disease (CPPDD), is a frequent multifactorial condition in the elderly, but there are two rare autosomal dominant Mendelian forms, CCAL1 (OMIM %600668) and …
View article: The Compositions of Rocky Planets in Close-in Orbits Tend to Be Earth-like
The Compositions of Rocky Planets in Close-in Orbits Tend to Be Earth-like Open
Hundreds of exoplanets between 1 and 1.8 times the size of Earth have been discovered on close-in orbits. However, these planets show such a diversity in densities that some appear to be made entirely of iron, while others appear to host g…
View article: A Hot Jupiter with a Retrograde Orbit Around A Sun-like Star and a Toy Model of Hot Jupiters in Wide Binary Star Systems
A Hot Jupiter with a Retrograde Orbit Around A Sun-like Star and a Toy Model of Hot Jupiters in Wide Binary Star Systems Open
We report an observation of a transit of the hot Jupiter (HJ) KELT-23A b with the Keck Planet Finder spectrograph and a measurement of the sky-projected obliquity ( λ ) of its Sun-like ( T eff ≈ 5900 K) host star. We measured a projected s…
View article: Is Handheld Ultrasonography Reliable as a Primary Imaging Modality for the Diagnosis of Internal Derangement and Degenerative Joint Disease of the Temporomandibular Joint?
Is Handheld Ultrasonography Reliable as a Primary Imaging Modality for the Diagnosis of Internal Derangement and Degenerative Joint Disease of the Temporomandibular Joint? Open
HHU demonstrated statistically significant specificity and PPV when assessing ID and shows promise as a screening tool for MRI referrals, helping to identify patients who can be maintained on conservative treatment. The diagnostic ability …
View article: Rig3R: Rig-Aware Conditioning for Learned 3D Reconstruction
Rig3R: Rig-Aware Conditioning for Learned 3D Reconstruction Open
Estimating agent pose and 3D scene structure from multi-camera rigs is a central task in embodied AI applications such as autonomous driving. Recent learned approaches such as DUSt3R have shown impressive performance in multiview settings.…
View article: Fetal Growth Chart in Twins Consistent with The FMF Growth Curve:Prospective Multicenter Study
Fetal Growth Chart in Twins Consistent with The FMF Growth Curve:Prospective Multicenter Study Open
Objectives: Different retrospective growth charts for twin pregnancies debates whether twin growth is similar to singletons. Recently, the fetal medicine foundation (FMF) published a retrospective fetal growth chart that indicated similar …
View article: TOI-6324 b: An Earth-mass Ultra-short-period Planet Transiting a Nearby M Dwarf
TOI-6324 b: An Earth-mass Ultra-short-period Planet Transiting a Nearby M Dwarf Open
We report the confirmation of TOI-6324 b, an Earth-sized (1.059 ± 0.041 R ⊕ ) ultra-short-period (USP) planet orbiting a nearby (∼20 pc) M dwarf. Using the newly commissioned Keck Planet Finder spectrograph, we have measured the mass of TO…
View article: A disease-specific convergence of host and Epstein–Barr virus genetics in multiple sclerosis
A disease-specific convergence of host and Epstein–Barr virus genetics in multiple sclerosis Open
Recent sero-epidemiological studies have strengthened the hypothesis that Epstein–Barr virus (EBV) may be a causal factor in multiple sclerosis (MS). Given the complexity of the EBV–host interaction, various mechanisms may be responsible f…
View article: Social Pain and Opioid Misuse: A Synergistic Epidemic (Syndemic)
Social Pain and Opioid Misuse: A Synergistic Epidemic (Syndemic) Open
Social pain is the metaphorical equivalent of physical pain triggered by thought, emotion, interpersonal problems, and expectations. The consensus on the role of social pain in understanding and managing opioid misuse is yet to be reached,…
View article: GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets Open
Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to psoriasis is not …
View article: TOI-6324b: An Earth-Mass Ultra-Short-Period Planet Transiting a Nearby M Dwarf
TOI-6324b: An Earth-Mass Ultra-Short-Period Planet Transiting a Nearby M Dwarf Open
We report the confirmation of TOI-6324 b, an Earth-sized (1.059 $\pm$ 0.041 R$_\oplus$) ultra-short-period (USP) planet orbiting a nearby ($\sim$20 pc) M dwarf. Using the newly commissioned Keck Planet Finder (KPF) spectrograph, we have me…
View article: P-525. HIV/STI Screening and Prevention in Hospitalized Patients with Opioid Use Disorder
P-525. HIV/STI Screening and Prevention in Hospitalized Patients with Opioid Use Disorder Open
Background Patients with opioid use disorder (OUD) are at increased risk of acquiring HIV and HCV. While this association is well-established for injection drug use (IDU), HCV and HIV transmission risk may be elevated among people with OUD…
View article: Associations of sociodemographic, clinical factors and HLA-B alleles with enthesitis and peripheral arthritis in patients with ankylosing spondylitis
Associations of sociodemographic, clinical factors and HLA-B alleles with enthesitis and peripheral arthritis in patients with ankylosing spondylitis Open
Objectives Factors associated with peripheral arthritis and enthesitis, especially Achilles tendonitis and plantar fasciitis, were examined in a longitudinal cohort of 1075 patients with ankylosing spondylitis (AS) (also known as radiograp…
View article: Large-Scale Pharmacogenomics Analysis of Patients With Cancer Within the 100,000 Genomes Project Combining Whole-Genome Sequencing and Medical Records to Inform Clinical Practice
Large-Scale Pharmacogenomics Analysis of Patients With Cancer Within the 100,000 Genomes Project Combining Whole-Genome Sequencing and Medical Records to Inform Clinical Practice Open
PURPOSE As part of the 100,000 Genomes Project, we set out to assess the potential viability and clinical impact of reporting genetic variants associated with drug-induced toxicity for patients with cancer recruited for whole-genome sequen…
View article: Asteroseismology of the Nearby K Dwarf σ Draconis Using the Keck Planet Finder and TESS
Asteroseismology of the Nearby K Dwarf σ Draconis Using the Keck Planet Finder and TESS Open
Asteroseismology of dwarf stars cooler than the Sun is very challenging owing to the low amplitudes and rapid timescales of oscillations. Here we present the asteroseismic detection of solar-like oscillations at 4-minute timescales ( …
View article: The Compositions of Rocky Planets in Close-in Orbits Tend to be Earth-Like
The Compositions of Rocky Planets in Close-in Orbits Tend to be Earth-Like Open
Hundreds of exoplanets between 1-1.8 times the size of the Earth have been discovered on close in orbits. However, these planets show such a diversity in densities that some appear to be made entirely of iron, while others appear to host g…
View article: Large-scale analysis of whole genome sequencing data from formalin-fixed paraffin-embedded cancer specimens demonstrates preservation of clinical utility
Large-scale analysis of whole genome sequencing data from formalin-fixed paraffin-embedded cancer specimens demonstrates preservation of clinical utility Open
Whole genome sequencing (WGS) provides comprehensive, individualised cancer genomic information. However, routine tumour biopsies are formalin-fixed and paraffin-embedded (FFPE), damaging DNA, historically limiting their use in WGS. Here w…
View article: Pregnancy-Related Factors and Breast Cancer Risk for Women Across a Range of Familial Risk
Pregnancy-Related Factors and Breast Cancer Risk for Women Across a Range of Familial Risk Open
Importance Few studies have investigated whether the associations between pregnancy-related factors and breast cancer (BC) risk differ by underlying BC susceptibility. Evidence regarding variation in BC risk is critical to understanding BC…