Markus W. Büchler
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View article: Supplementary Table S3 from Blood-Based Diagnosis and Risk Stratification of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN)
Supplementary Table S3 from Blood-Based Diagnosis and Risk Stratification of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN) Open
List of miRNA molecules screened for their use as biomarkers.
View article: Supplementary Table S7 from Blood-Based Diagnosis and Risk Stratification of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN)
Supplementary Table S7 from Blood-Based Diagnosis and Risk Stratification of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN) Open
List of extra miRNA classifiers.
View article: Supplementary Table S8 from Blood-Based Diagnosis and Risk Stratification of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN)
Supplementary Table S8 from Blood-Based Diagnosis and Risk Stratification of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN) Open
List of combined protein-miRNA classifiers.
View article: Supplementary Figure S3 from Blood-Based Diagnosis and Risk Stratification of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN)
Supplementary Figure S3 from Blood-Based Diagnosis and Risk Stratification of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN) Open
Diagnostic performance obtained by four independent repetitions of creating a SVM classifier on the basis of the clinical parameters recorded for the 302 IPMN patients.
View article: Indications and outcome of surgery for small nonfunctioning pancreatic neuroendocrine neoplasms (≤2 cm)
Indications and outcome of surgery for small nonfunctioning pancreatic neuroendocrine neoplasms (≤2 cm) Open
Surgical treatment of small (≤2 cm) pancreatic neuroendocrine neoplasms provides excellent long-term survival. Since even small pancreatic neuroendocrine neoplasms can develop lymph node and distant metastases, treatment decisions should n…
View article: Management of bilioenteric anastomosis leakage after major liver resection
Management of bilioenteric anastomosis leakage after major liver resection Open
Background Post-hepatectomy bile leakage is a challenging issue that can lead to morbidities and mortality after liver resection. This leakage can occur either from a bilioenteric anastomosis (BEA) or from the transected surface of the liv…
View article: Selective neoadjuvant therapy of rectal cancer patients (SELREC): study protocol for a European randomised controlled, open, multicentre non-inferiority trial
Selective neoadjuvant therapy of rectal cancer patients (SELREC): study protocol for a European randomised controlled, open, multicentre non-inferiority trial Open
Introduction Neoadjuvant (chemo)radiotherapy (n(C)RT) followed by resection with total mesorectal excision (TME) constitutes the standard treatment for patients with locally advanced rectal cancer of the middle and lower third. However, n(…
View article: Histology-driven tailoring of surgical approaches in retroperitoneal soft tissue sarcoma: retrospective cohort study
Histology-driven tailoring of surgical approaches in retroperitoneal soft tissue sarcoma: retrospective cohort study Open
Background Histology-driven tailoring of surgical approaches for retroperitoneal soft tissue sarcoma is currently under debate. Compelling evidence assessing the role of histology-dependent extent of resection is lacking. The aim of this s…
View article: Rethinking Abdominal Drainage After Distal Pancreatectomy – The PANDRA II Trial
Rethinking Abdominal Drainage After Distal Pancreatectomy – The PANDRA II Trial Open
Background Prophylactic intraabdominal drainage following distal pancreatectomy (DP) has been a longstanding practice to mitigate postoperative complications, particularly postoperative pancreatic fistulas (POPF). Recent studies challenge …
View article: Therapie des Pankreaskarzinoms: Innovative Chirurgie und moderne Systemtherapien
Therapie des Pankreaskarzinoms: Innovative Chirurgie und moderne Systemtherapien Open
View article: GATA6 immunohistochemistry and prognosis after surgical resection of pancreatic adenocarcinoma: results from the ESPAC-4 trial
GATA6 immunohistochemistry and prognosis after surgical resection of pancreatic adenocarcinoma: results from the ESPAC-4 trial Open
Background: No prognostic biomarker is currently used in clinical management of patients with surgically resected pancreatic cancer other than CA-19-9. In this study, we tested the prognostic value of GATA6 measured with immunohistochemist…
View article: Temporal variation in nutritional status and preoperative anemia among patients with retroperitoneal soft tissue sarcoma: a retrospective longitudinal cohort study
Temporal variation in nutritional status and preoperative anemia among patients with retroperitoneal soft tissue sarcoma: a retrospective longitudinal cohort study Open
Purpose Optimal management of retroperitoneal soft tissue sarcoma (RPS) often requires extensive tumor resections, frequently involving gastrointestinal organs. The impact of these procedures on the nutritional status and hemoglobin (Hb) l…
View article: Combined analysis of a serum mRNA/miRNA marker signature and CA 19‐9 for timely and accurate diagnosis of recurrence after resection of pancreatic ductal adenocarcinoma: A prospective multicenter cohort study
Combined analysis of a serum mRNA/miRNA marker signature and CA 19‐9 for timely and accurate diagnosis of recurrence after resection of pancreatic ductal adenocarcinoma: A prospective multicenter cohort study Open
Background and Aims Timely and accurate detection of tumor recurrence in pancreatic ductal adenocarcinoma (PDAC) patients is an urgent and unmet medical need. This study aimed to develop a noninvasive molecular diagnostic procedure for the…
View article: Preoperative Inflammatory Scores Do Not Accurately Predict Early Recurrence of Pancreatic Ductal Adenocarcinoma After Resection: A Systematic Review and Meta‐Analysis
Preoperative Inflammatory Scores Do Not Accurately Predict Early Recurrence of Pancreatic Ductal Adenocarcinoma After Resection: A Systematic Review and Meta‐Analysis Open
Background Disease recurrence after surgical resection for pancreatic ductal adenocarcinoma can affect more than 50% of patients in the first 12 months after resection. The goal of this current systematic review and meta‐analysis is to ass…
View article: Two decades of advances in clinical oncology — lessons learned and future directions
Two decades of advances in clinical oncology — lessons learned and future directions Open
View article: Influence of dental status on postoperative complications in major visceral surgical and organ transplantation procedures—the bellydent retrospective observational study
Influence of dental status on postoperative complications in major visceral surgical and organ transplantation procedures—the bellydent retrospective observational study Open
View article: Intraoperative end-tidal carbon dioxide levels are not associated with recurrence-free survival after elective pancreatic cancer surgery: a retrospective cohort study
Intraoperative end-tidal carbon dioxide levels are not associated with recurrence-free survival after elective pancreatic cancer surgery: a retrospective cohort study Open
Background Intraoperative end-tidal carbon dioxide concentrations (EtCO 2 ) values are associated with recurrence-free survival after colorectal cancer surgery. However, it is unknown if similar effects can be observed after other surgical…
View article: Therapie des Pankreaskarzinoms: Innovative Chirurgie und moderne Systemtherapien
Therapie des Pankreaskarzinoms: Innovative Chirurgie und moderne Systemtherapien Open
View article: Outcomes in intraductal papillary mucinous neoplasm‐derived pancreatic cancer differ from PanIN‐derived pancreatic cancer
Outcomes in intraductal papillary mucinous neoplasm‐derived pancreatic cancer differ from PanIN‐derived pancreatic cancer Open
Background and Aim Intraductal papillary mucinous neoplasm (IPMN)‐derived pancreatic ductal adenocarcinoma (PDAC) management is generally extrapolated from pancreatic intraepithelial neoplasia (PanIN)‐derived PDAC guidelines. However, thes…
View article: An international multi-institutional validation of T1 sub-staging of intraductal papillary mucinous neoplasm-derived pancreatic cancer
An international multi-institutional validation of T1 sub-staging of intraductal papillary mucinous neoplasm-derived pancreatic cancer Open
Background Intraductal papillary mucinous neoplasm (IPMN)–derived pancreatic ductal adenocarcinoma (PDAC) is resected at smaller sizes compared with its biologically distinct counterpart, pancreatic intraepithelial neoplasia (PanIN)–derive…
View article: Deep Learning Histology for Prediction of Lymph Node Metastases and Tumor Regression after Neoadjuvant FLOT Therapy of Gastroesophageal Adenocarcinoma
Deep Learning Histology for Prediction of Lymph Node Metastases and Tumor Regression after Neoadjuvant FLOT Therapy of Gastroesophageal Adenocarcinoma Open
Background: The aim of this study was to establish a deep learning prediction model for neoadjuvant FLOT chemotherapy response. The neural network utilized clinical data and visual information from whole-slide images (WSIs) of therapy-naïv…
View article: Preoperative Surgical or Endoscopic Bile Duct Drainage in Pancreatic Cancer
Preoperative Surgical or Endoscopic Bile Duct Drainage in Pancreatic Cancer Open
Background: Patients with pancreatic cancer and obstructive jaundice routinely undergo endoscopic stent placement (ES). It is well known that ES causes bacterial contamination and infectious complications after pancreatic resection. Object…
View article: Combined analysis of albumin in situ hybridisation and C reactive protein immunohistochemistry for the diagnosis of intrahepatic cholangiocarcinoma: towards a molecular classification paradigm
Combined analysis of albumin in situ hybridisation and C reactive protein immunohistochemistry for the diagnosis of intrahepatic cholangiocarcinoma: towards a molecular classification paradigm Open
Aims Intrahepatic cholangiocarcinoma (iCCA) is a diagnosis of exclusion that can pose a challenge to the pathologist despite thorough clinical workup. Although several immunohistochemical markers have been proposed for iCCA, none of them r…
View article: Low intraoperative end-tidal carbon dioxide levels are associated with improved recurrence-free survival after elective colorectal cancer surgery
Low intraoperative end-tidal carbon dioxide levels are associated with improved recurrence-free survival after elective colorectal cancer surgery Open
Lower intraoperative EtCO2 target values in CRC surgery might benefit oncological outcome and should be evaluated in confirmative studies.
View article: Influence of Dental Status on Postoperative Complications in Major Visceral Surgical and Organ Transplantation Procedures - the BellyDent retrospective observational Study
Influence of Dental Status on Postoperative Complications in Major Visceral Surgical and Organ Transplantation Procedures - the BellyDent retrospective observational Study Open
Background The significance of dental status and oral hygiene on a range of medical conditions is well-recognised. However, the correlation between periodontitis, oral bacterial dysbiosis and visceral surgical outcomes is less well establi…
View article: Robotic versus open partial pancreatoduodenectomy (EUROPA): a randomised controlled stage 2b trial
Robotic versus open partial pancreatoduodenectomy (EUROPA): a randomised controlled stage 2b trial Open
View article: The PAncreatic Surgery Composite Endpoint (PACE)
The PAncreatic Surgery Composite Endpoint (PACE) Open
Objective: To provide a composite endpoint in pancreatic surgery. Background: Single endpoints in prospective and randomized studies have become impractical due to their low frequency and the marginal benefit of new interventions. Methods:…
View article: Promising Outcomes of Modified ALPPS for Staged Hepatectomy in Cholangiocarcinoma
Promising Outcomes of Modified ALPPS for Staged Hepatectomy in Cholangiocarcinoma Open
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a two-stage procedure that can potentially cure patients with large cholangiocarcinoma. The current study evaluates the impact of modifications on the o…
View article: Impact of circumferential resection margin on survival in ampullary cancer: retrospective analysis
Impact of circumferential resection margin on survival in ampullary cancer: retrospective analysis Open
Background Ampullary carcinoma is a clinically variable entity. This study aimed to evaluate prognostic factors for the outcome of resected ampullary carcinoma patients with particular intent to analyse the influence of surgical radicality…
View article: Risk factors and management of biliary leakage after Endocystectomy for hepatic cystic echinococcosis
Risk factors and management of biliary leakage after Endocystectomy for hepatic cystic echinococcosis Open
Background Endocystectomy is a conservative surgical approach to managing cystic echinococcosis. Bile leakage is the main complication of this technique. The aim of this study was to evaluate the factors associated with bile leakage and to…