Bryan Williams
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View article: (ID: 153) Focus groups exploring the challenges and potential solutions to pharmacy professionals engaging with research in the UK
(ID: 153) Focus groups exploring the challenges and potential solutions to pharmacy professionals engaging with research in the UK Open
Introduction Research is essential to the advancement of pharmacy practice; however, engagement within the profession remains limited [1]. Previous studies exploring barriers to research engagement have largely focused on specific sectors …
View article: Long-Term Efficacy and Safety of a Novel Low-Dose Triple Single-Pill Combination for the Treatment of Hypertension
Long-Term Efficacy and Safety of a Novel Low-Dose Triple Single-Pill Combination for the Treatment of Hypertension Open
Background: A novel low-dose triple single-pill combination of antihypertensive drugs (GMRx2) has demonstrated superior blood pressure (BP)-lowering efficacy compared to placebo and dual combinations in short-term randomized double-blind t…
View article: Renal Denervation in Patients With Moderate to Severe Chronic Kidney Disease
Renal Denervation in Patients With Moderate to Severe Chronic Kidney Disease Open
BACKGROUND: Uncontrolled hypertension is common in patients with chronic kidney disease (CKD), putting these patients at high risk for adverse cardiovascular events. Radiofrequency renal denervation (RDN) lowers blood pressure (BP) in pati…
View article: Design and development of a SARS and MERS Combination Vaccine
Design and development of a SARS and MERS Combination Vaccine Open
This work was conducted during the COVID-19 pandemic prior to the licensing of any vaccines against COVID-19. Although several COVID-19 vaccines are now commercially available, this research on the development of a combination Severe Acute…
View article: Development and evaluation of Z-score based aortic diameter thresholds for early detection of thoracic aortic dissection and aneurysm: Analysis in the UK Biobank
Development and evaluation of Z-score based aortic diameter thresholds for early detection of thoracic aortic dissection and aneurysm: Analysis in the UK Biobank Open
Background & Purpose: Clinical guidelines recommend using an absolute ascending aortic diameter (AAD) cutoff of 4.5 cm for monitoring and 5.5 cm for surgery in people at risk of thoracic aortic dissection. However, AAD varies with age, sex…
View article: P04.10.A ARE FOUNDATIONAL AI SPEECH MODELS READY FOR NEURO-ONCOLOGY? THE BRAINAPP STUDY SAYS “NOT YET”
P04.10.A ARE FOUNDATIONAL AI SPEECH MODELS READY FOR NEURO-ONCOLOGY? THE BRAINAPP STUDY SAYS “NOT YET” Open
BACKGROUND Primary brain tumours (BTs) can cause diverse neurological deficits, including speech impairments. An objective and rapid speech assessment method is crucial for effective patient monitoring, support, and rehabilitation. However…
View article: How Sleep Deprivation and Optimization May Impact Health and Performance
How Sleep Deprivation and Optimization May Impact Health and Performance Open
Adequate sleep is crucial for health and well-being. Research shows that 1 in 3 Americans reportedly sleep less than the recommended guidelines and over 70 million experience some type of chronic sleep issue. Sleep deprivation has been sho…
View article: TFV‐DP and FTC‐TP using volumetric absorptive microsampling compared with DBS among persons receiving TDF/FTC or TAF/FTC
TFV‐DP and FTC‐TP using volumetric absorptive microsampling compared with DBS among persons receiving TDF/FTC or TAF/FTC Open
View article: GENOME-WIDE ASSOCIATION STUDY OF AORTIC STIFFNESS DERIVED FROM DEEP LEARNING IN CMR IMAGES OF 45 789 INDIVIDUALS IDENTIFIES LOCI LINKED WITH CELL-MATRIX STRUCTURE
GENOME-WIDE ASSOCIATION STUDY OF AORTIC STIFFNESS DERIVED FROM DEEP LEARNING IN CMR IMAGES OF 45 789 INDIVIDUALS IDENTIFIES LOCI LINKED WITH CELL-MATRIX STRUCTURE Open
Background Aortic stiffness is a key determinant of cardiovascular disease (CVD) risk. Advances in deep learning on cardiac magnetic resonance (CMR) imaging enable detailed phenotyping of cardiac traits, providing novel insights into CVD g…
View article: Blood pressure management in secondary prevention after myocardial infarction
Blood pressure management in secondary prevention after myocardial infarction Open
The management of blood pressure (BP) in secondary prevention after acute myocardial infarction (AMI) remains a matter of debate. Since no dedicated trials have specifically addressed BP control in patients recovering from an acute coronar…
View article: Baxdrostat for uncontrolled and resistant hypertension: rationale and design of the Phase 3 clinical trials BaxHTN, BaxAsia, and Bax24
Baxdrostat for uncontrolled and resistant hypertension: rationale and design of the Phase 3 clinical trials BaxHTN, BaxAsia, and Bax24 Open
Inappropriately elevated aldosterone is a common feature of uncontrolled hypertension (uHTN) and resistant hypertension (rHTN), and is a major pathophysiological driver of adverse cardiorenal outcomes beyond elevated blood pressure (BP). B…
View article: Third exposure to COVID-19 infection or vaccination differentially impacts T cell responses
Third exposure to COVID-19 infection or vaccination differentially impacts T cell responses Open
View article: 2-042 Ethnic disparities in mortality from acute coronary syndrome: a multicentre cohort study
2-042 Ethnic disparities in mortality from acute coronary syndrome: a multicentre cohort study Open
View article: Long-term outcomes following radiofrequency renal denervation: meta-analysis of 18 reports
Long-term outcomes following radiofrequency renal denervation: meta-analysis of 18 reports Open
Aims Radiofrequency (RF) renal denervation (RDN) safely lowers office and 24-h blood pressure (BP). This meta-analysis examined the long-term durability of RF RDN based on randomized trials and observational studies. Methods and results Pa…
View article: Correction: DNA methylation profiles of long-term cannabis users in midlife: a comprehensive evaluation of published cannabis-associated methylation markers in a representative cohort
Correction: DNA methylation profiles of long-term cannabis users in midlife: a comprehensive evaluation of published cannabis-associated methylation markers in a representative cohort Open
View article: Between guidelines and reality; the complex decision-making of acute cholecystitis in pregnancy
Between guidelines and reality; the complex decision-making of acute cholecystitis in pregnancy Open
Despite current guidelines recommending surgical intervention, our study reveals that non-operative management remains the predominant approach in real-world practice. While it is associated with a high rate of symptom recurrence and postp…
View article: Tendons under load: Understanding pathology and progression
Tendons under load: Understanding pathology and progression Open
View article: 925 Recovery From Secondary vs. Primary Breast-Surgery Procedures Measured Using Smartphone Step-Count Data: A Walk in the Park?
925 Recovery From Secondary vs. Primary Breast-Surgery Procedures Measured Using Smartphone Step-Count Data: A Walk in the Park? Open
Aim Analysis of patients’ smartphone activity data has recently been validated as a novel recovery-metric after breast surgery. The aim of this study was to compare recovery from secondary breast procedures (symmetrisation, re-reduction an…
View article: Investigation of Influenza A(H5N1) Virus Neutralization by Quadrivalent Seasonal Vaccines, United Kingdom, 2021–2024
Investigation of Influenza A(H5N1) Virus Neutralization by Quadrivalent Seasonal Vaccines, United Kingdom, 2021–2024 Open
We tested cross-neutralization against highly pathogenic avian influenza A(H5N1) virus in adults vaccinated with 2021-2023 seasonal quadrivalent influenza vaccine in the United Kingdom. Seasonal quadrivalent influenza vaccines are unlikely…
View article: PsiConnect: A Multimodal Neuroimaging Study of Psilocybin-Induced Changes in Brain and Behaviour
PsiConnect: A Multimodal Neuroimaging Study of Psilocybin-Induced Changes in Brain and Behaviour Open
PsiConnect is a large-scale neuroimaging study designed to investigate the neural and subjective effects of psilocybin using multimodal neuroimaging. It combines functional, structural, and diffusion-weighted MRI with EEG to examine brain …
View article: Psychedelics Align Brain Activity with Context
Psychedelics Align Brain Activity with Context Open
Psychedelics can profoundly alter consciousness by reorganising brain connectivity; however, their effects are contextsensitive. To understand how this reorganisation depends on the context, we collected and comprehensively analysed the la…
View article: Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1 in the assessment of vaccination and therapeutics
Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1 in the assessment of vaccination and therapeutics Open
Emerging SARS-CoV-2 variants require rapid assessments of pathogenicity and evasion of existing immunity to inform policy. A crucial component of these assessments is accurate estimation of serum neutralising antibody titres using cultured…
View article: 15 Divergent performance of bivalent BA.5 and monovalent XBB.1.5 COVID-19 vaccines given as annual booster
15 Divergent performance of bivalent BA.5 and monovalent XBB.1.5 COVID-19 vaccines given as annual booster Open
View article: 24 B cell depletion therapy in people with Multiple Sclerosis impacts on antibody response to COVID-19 mRNA vaccines
24 B cell depletion therapy in people with Multiple Sclerosis impacts on antibody response to COVID-19 mRNA vaccines Open
View article: Healthy lifestyle factors and combined macrovascular and microvascular events in diabetes patients with high cardiovascular risk: results from ADVANCE
Healthy lifestyle factors and combined macrovascular and microvascular events in diabetes patients with high cardiovascular risk: results from ADVANCE Open
View article: Comparative effectiveness and prescribing trends of modified release versus immediate release indapamide in patients with hypertension: cohort study
Comparative effectiveness and prescribing trends of modified release versus immediate release indapamide in patients with hypertension: cohort study Open
Objective To investigate the prescribing trends of indapamide, a thiazide-like diuretic, and the long term comparative effectiveness of modified release versus immediate release indapamide. Design Cohort study. Setting IQVIA Medical Resear…
View article: Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion
Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion Open
Coronaviruses express their structural and accessory genes via a set of subgenomic RNAs, whose synthesis is directed by transcription regulatory sequences (TRSs) in the 5′ genomic leader and upstream of each body open reading frame. In SAR…
View article: Early recognition and management of gangrenous cholecystitis: a single-center experience and a comprehensive review of risk factors and imaging findings
Early recognition and management of gangrenous cholecystitis: a single-center experience and a comprehensive review of risk factors and imaging findings Open
Background: Annually, approximately 200,000 acute cholecystitis (AC) cases are diagnosed in the U.S., with gangrenous cholecystitis (GC) occurring in 2-20% of AC cases. GC, characterized by ischemic necrosis of the gallbladder, is often as…
View article: Self-monitoring of blood pressure following a stroke or transient ischaemic attack (TASMIN5S): a randomised controlled trial
Self-monitoring of blood pressure following a stroke or transient ischaemic attack (TASMIN5S): a randomised controlled trial Open
Background Blood pressure (BP) control following stroke is important but currently sub-optimal. This trial aimed to determine whether self-monitoring of hypertension with telemonitoring and a treatment escalation protocol, results in lower…
View article: Photochemically-enabled, post-translational production of C-terminal amides
Photochemically-enabled, post-translational production of C-terminal amides Open
C-terminal α-amidated peptides are attractive therapeutic targets, but preparative methods to access amidated pharmaceuticals are limited both on lab and manufacturing-scale. Here we report a straightforward and scalable approach to the C-…