Marco Cafora
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View article: Air pollution, nasal microbiota, and bronchiolitis: understanding their interplay through a multilevel approach
Air pollution, nasal microbiota, and bronchiolitis: understanding their interplay through a multilevel approach Open
Bronchiolitis is a severe acute lower respiratory tract condition in infants, with respiratory syncytial virus (RSV) infection being a leading cause. Despite extensive research, the factors influencing the severity of bronchiolitis remain …
View article: Identification and impact on <i>Pseudomonas aeruginosa</i> virulence of mutations conferring resistance to a phage cocktail for phage therapy
Identification and impact on <i>Pseudomonas aeruginosa</i> virulence of mutations conferring resistance to a phage cocktail for phage therapy Open
Phage therapy represents a promising strategy for curing bacterial infections refractory to antibiotics. However, the success rate of phage therapy may be lowered by the emergence of bacterial resistance to the phages used for therapy. In …
View article: Lemon-derived nanovesicles achieve antioxidant and anti-inflammatory effects activating the AhR/Nrf2 signaling pathway
Lemon-derived nanovesicles achieve antioxidant and anti-inflammatory effects activating the AhR/Nrf2 signaling pathway Open
In the last years, extracellular vesicles (EVs) from different plant matrices have been isolated and gained the interest of the scientific community for their intriguing biological properties. In this study, we isolated and characterized n…
View article: PCSK9 Confers Inflammatory Properties to Extracellular Vesicles Released by Vascular Smooth Muscle Cells
PCSK9 Confers Inflammatory Properties to Extracellular Vesicles Released by Vascular Smooth Muscle Cells Open
Vascular smooth muscle cells (VSMCs) are key participants in both early- and late-stage atherosclerosis and influence neighbouring cells possibly by means of bioactive molecules, some of which are packed into extracellular vesicles (EVs). …
View article: <scp>PM<sub>2</sub></scp><sub>.5,</sub><scp>PM<sub>10</sub></scp> and bronchiolitis severity: A cohort study
<span>PM<sub>2</sub></span><sub>.5,</sub><span>PM<sub>10</sub></span> and bronchiolitis severity: A cohort study Open
Background A few studies suggest that particulate matter (PM) exposure might play a role in bronchiolitis. However, available data are mostly focused on the risk of hospitalization and come from retrospective studies that provided conflict…
View article: Evaluation of phages and liposomes as combination therapy to counteract Pseudomonas aeruginosa infection in wild-type and CFTR-null models
Evaluation of phages and liposomes as combination therapy to counteract Pseudomonas aeruginosa infection in wild-type and CFTR-null models Open
Multi drug resistant (MDR) bacteria are insensitive to the most common antibiotics currently in use. The spread of antibiotic-resistant bacteria, if not contained, will represent the main cause of death for humanity in 2050. The situation …
View article: Animal Models to Translate Phage Therapy to Human Medicine
Animal Models to Translate Phage Therapy to Human Medicine Open
Phagotherapy, the use of bacteriophages to fight bacterial infections as an alternative to antibiotic treatments, has become of increasing interest in the last years. This is mainly due to the diffusion of multi-drug resistant (MDR) bacter…
View article: Phage Therapy Application to Counteract <em>Pseudomonas aeruginosa</em> Infection in Cystic Fibrosis Zebrafish Embryos
Phage Therapy Application to Counteract <em>Pseudomonas aeruginosa</em> Infection in Cystic Fibrosis Zebrafish Embryos Open
Antimicrobial resistance, a major consequence of diagnostic uncertainty and antimicrobial overprescription, is an increasingly recognized cause of severe infections, complications, and mortality worldwide with a huge impact on our society …
View article: Extracellular Vesicles Released by Colorectal Cancer Cell Lines Modulate Innate Immune Response in Zebrafish Model: The Possible Role of Human Endogenous Retroviruses
Extracellular Vesicles Released by Colorectal Cancer Cell Lines Modulate Innate Immune Response in Zebrafish Model: The Possible Role of Human Endogenous Retroviruses Open
Extracellular vesicles (EVs) are important components of the metastatic niche and are crucial in infiltration, metastasis, and immune tolerance processes during tumorigenesis. We hypothesized that human endogenous retroviruses (HERV) posit…
View article: Design of a Broad-Range Bacteriophage Cocktail That Reduces Pseudomonas aeruginosa Biofilms and Treats Acute Infections in Two Animal Models
Design of a Broad-Range Bacteriophage Cocktail That Reduces Pseudomonas aeruginosa Biofilms and Treats Acute Infections in Two Animal Models Open
The alarming diffusion of multidrug-resistant (MDR) bacterial strains requires investigations on nonantibiotic therapies. Among such therapies, the use of bacteriophages (phages) as antimicrobial agents, namely, phage therapy, is a promisi…