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View article: Global DNA hypomethylation in canine mammary tumors
Global DNA hypomethylation in canine mammary tumors Open
Due to its influence in transcriptional potential of genes, genetic regulation by means of epigenetic mechanisms is essential for normal growth and development. In mammary cancer, epigenetic modifications play a key role for its developmen…
View article: Molecular Impacts of Occupational Exposure to Waste Anesthetic Gases
Molecular Impacts of Occupational Exposure to Waste Anesthetic Gases Open
Millions of healthcare professionals are occupationally exposed to waste anesthetic gases (WAGs) worldwide; however, their effect on DNA methylation is unknown. Thus, for the first time, global DNA methylation analysis was performed in add…
View article: Cost-effective promoter methylation analysis via target long-read bisulfite sequencing: a case study in severe preterm birth
Cost-effective promoter methylation analysis via target long-read bisulfite sequencing: a case study in severe preterm birth Open
View article: Targeted Long-Read Bisulfite Sequencing for Promoter Methylation Analysis in Severe Preterm Birth
Targeted Long-Read Bisulfite Sequencing for Promoter Methylation Analysis in Severe Preterm Birth Open
DNA methylation plays a critical role in the dynamics of gene expression regulation and the development of various disorders. Whole-genome bisulfite sequencing can provide single base resolution of CpG methylation levels and is the “gold s…
View article: Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy
Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy Open
Cellular senescence is a therapy endpoint in melanoma, and the senescence-associated secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing treatment outcomes. Metabolic interventions can modulate the SASP, an…
View article: Using Telomeric Length Measurements and Methylation to Understand The Karyotype Diversification of Ctenomys Minutus (A Small Fossorial Mammals)
Using Telomeric Length Measurements and Methylation to Understand The Karyotype Diversification of Ctenomys Minutus (A Small Fossorial Mammals) Open
The genus Ctenomys has been widely used in karyotype evolution studies due to the variation in their diploid numbers (2n), which range from 2n = 10 to 2n = 70. Ctenomys minutus is characterized by intraspecific variation in diploid number …
View article: Ancestría genética y estratificación social en Montevideo, Uruguay
Ancestría genética y estratificación social en Montevideo, Uruguay Open
Diversos estudios genéticos han demostrado que la población uruguaya es trihíbrida, formada por europeo/mediterráneos, indígenas y africanos, cuyo aporte varía en distintas regiones del país. Pese a que Montevideo es la capital de la Repúb…
View article: Discovery of novel DNA methylation biomarkers for non‐invasive sporadic breast cancer detection in the Latino population
Discovery of novel DNA methylation biomarkers for non‐invasive sporadic breast cancer detection in the Latino population Open
Human diversity is one of the main pitfalls in the development of robust worldwide biomarkers in oncology. Epigenetic variability across human populations is associated with different genetic backgrounds, as well as variable lifestyles and…
View article: Genomic Diversity in Sporadic Breast Cancer in a Latin American Population
Genomic Diversity in Sporadic Breast Cancer in a Latin American Population Open
Among Latin American women, breast cancer incidences vary across populations. Uruguay and Argentina have the highest rates in South America, which are mainly attributed to strong, genetic European contributions. Most genetic variants assoc…
View article: Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure
Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure Open
View article: Occupational Exposure to Pesticides in Tobacco Fields: The Integrated Evaluation of Nutritional Intake and Susceptibility on Genomic and Epigenetic Instability
Occupational Exposure to Pesticides in Tobacco Fields: The Integrated Evaluation of Nutritional Intake and Susceptibility on Genomic and Epigenetic Instability Open
Pesticides used at tobacco fields are associated with genomic instability, which is proposed to be sensitive to nutritional intake and may also induce epigenetic changes. We evaluated the effect of dietary intake and genetic susceptibility…
View article: Chronic occupational exposure endured by tobacco farmers from Brazil and association with DNA damage
Chronic occupational exposure endured by tobacco farmers from Brazil and association with DNA damage Open
Tobacco farming is an important economic income in Brazil, although it has been challenged as regard the occupational exposure to both pesticides and nicotine endured by farmers. Chronic occupational exposure to complex mixtures can lead t…
View article: DNA damage and epigenetic alteration in soybean farmers exposed to complex mixture of pesticides
DNA damage and epigenetic alteration in soybean farmers exposed to complex mixture of pesticides Open
Exposure to pesticides can trigger genotoxic and mutagenic processes through different pathways. However, epidemiological studies are scarce, and further work is needed to find biomarkers sensitive to the health of exposed populations. Con…
View article: Melanoma, ancestralidad y variantes MC1R en la población mestizada Uruguaya
Melanoma, ancestralidad y variantes MC1R en la población mestizada Uruguaya Open
View article: Melanoma, ancestry and MC1R variations in the uruguayan admixed population
Melanoma, ancestry and MC1R variations in the uruguayan admixed population Open
View article: Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients
Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients Open
View article: Breast cancer risk and genetic ancestry: a case–control study in Uruguay
Breast cancer risk and genetic ancestry: a case–control study in Uruguay Open
We have not found evidence that overall genetic ancestry differs between breast cancer patients and controls in Uruguay but we detected an association of the disease with a European mitochondrial lineage, which warrants further investigati…