L. Cardozo
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View article: Could Cultured Meat Be a Sustainable and Safe Source of Protein?
Could Cultured Meat Be a Sustainable and Safe Source of Protein? Open
Red and processed meat includes high‐quality proteins and essential sources of micronutrients, such as iron, zinc, and vitamin B12; however, high consumption is linked to an increased risk of chronic disease burden and also harms environme…
View article: Remodeling of Gut Microbial Networks After Sulforaphane Supplementation in Patients with Chronic Kidney Disease
Remodeling of Gut Microbial Networks After Sulforaphane Supplementation in Patients with Chronic Kidney Disease Open
Background and Objectives: Chronic kidney disease (CKD) is closely associated with gut dysbiosis, and sulforaphane (SFN), a bioactive compound found in cruciferous vegetables, may help to mitigate this condition. Methods: These are seconda…
View article: Apitherapy with Royal Jelly and Green Propolis EPP-AF® Improves Cardiovascular Risk Markers in Patients Undergoing Hemodialysis
Apitherapy with Royal Jelly and Green Propolis EPP-AF® Improves Cardiovascular Risk Markers in Patients Undergoing Hemodialysis Open
Background: Reducing cardiovascular risk markers is an essential target in chronic kidney disease (CKD). Thus, this study aimed to evaluate the effect of royal jelly plus green propolis supplementation on cardiovascular disease (CVD) risk …
View article: Hemodialysis Intensifies NLRP3 Inflammasome Expression and Oxidative Stress in Patients with Chronic Kidney Disease
Hemodialysis Intensifies NLRP3 Inflammasome Expression and Oxidative Stress in Patients with Chronic Kidney Disease Open
Chronic inflammation plays a central role in the progression and complications of chronic kidney disease (CKD). The nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome pathway has emerged as a crucial mediator of the inflammat…
View article: Bioactive Compounds as Modulators of N-Formyl Peptide Signaling in Chronic Diseases
Bioactive Compounds as Modulators of N-Formyl Peptide Signaling in Chronic Diseases Open
In physiological situations involving cell damage, molecules derived from mitochondria or bacteria are produced. These molecules are known as N-formyl peptides and are detected by formyl peptide receptors (FPRs), which stimulate immune cel…
View article: Artificial Intelligence–Enabled Analysis of Thermography to Diagnose Acute Decompensated Heart Failure
Artificial Intelligence–Enabled Analysis of Thermography to Diagnose Acute Decompensated Heart Failure Open
Thermography demonstrated differences between patients with ADHF and those with other cardiological disorders. In this proof of concept, combining thermography with artificial intelligence enabled the detection of ADHF in subjects hospital…
View article: Effects of Curcuma longa L. and Green Propolis Extract-Loaded Microcapsules Supplementation on Inflammation in Hemodialysis Patients: Preliminary Results of a Randomized Clinical Trial
Effects of Curcuma longa L. and Green Propolis Extract-Loaded Microcapsules Supplementation on Inflammation in Hemodialysis Patients: Preliminary Results of a Randomized Clinical Trial Open
Foods such as Curcuma longa L. and propolis can attenuate inflammation in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). This study aimed to evaluate the effects of microcapsules loaded with Curcuma longa L. and p…
View article: The Exposome and the Kidney: A Silent Dialogue Shaping Chronic Kidney Disease
The Exposome and the Kidney: A Silent Dialogue Shaping Chronic Kidney Disease Open
Genetic predisposition accounts for less than 20% of the global disease burden, highlighting the substantial role of environmental factors in health outcomes. In chronic kidney disease (CKD), a growing global prevalence, understanding the …
View article: Gut Microbiota and NLRP3 Inflammasome Activation in Hemodialysis Patients: Exploring the Link with Systemic Inflammation
Gut Microbiota and NLRP3 Inflammasome Activation in Hemodialysis Patients: Exploring the Link with Systemic Inflammation Open
Background The Nod-Like Receptor Pyrin domain-containing 3 (NLRP3) inflammasome is a critical sensor of bacterial signals and metabolites, initiating an inflammatory response. Chronic kidney disease (CKD) is often accompanied by systemic i…
View article: Effects of Tocotrienol on Cardiovascular Risk Markers in Patients With Chronic Kidney Disease: A Randomized Controlled Trial
Effects of Tocotrienol on Cardiovascular Risk Markers in Patients With Chronic Kidney Disease: A Randomized Controlled Trial Open
Tocotrienols, isomers of vitamin E, may provide an effective nutritional strategy to mitigate common cardiovascular risks such as dyslipidemia, inflammation, and oxidative stress in patients with chronic kidney disease (CKD). This double‐b…
View article: Trimethylamine N-Oxide (TMAO) Plasma Levels in Patients with Different Stages of Chronic Kidney Disease
Trimethylamine N-Oxide (TMAO) Plasma Levels in Patients with Different Stages of Chronic Kidney Disease Open
Background: In patients with chronic kidney disease (CKD), trimethylamine n-oxide (TMAO) accumulation exacerbates inflammation and contributes to oxidative stress. These complications are putatively linked to the development of cardiovascu…
View article: Effects of Propolis Supplementation on Gut Microbiota and Uremic Toxin Profiles of Patients Undergoing Hemodialysis
Effects of Propolis Supplementation on Gut Microbiota and Uremic Toxin Profiles of Patients Undergoing Hemodialysis Open
Background: Propolis possesses many bioactive compounds that could modulate the gut microbiota and reduce the production of uremic toxins in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). This clinical trial aimed…
View article: Effects of Cranberry Extract (Vaccinium macrocarpon) Supplementation on Lipid Peroxidation and Inflammation in Patients with Chronic Kidney Disease (Stages 3-4): A Randomized Controlled Trial
Effects of Cranberry Extract (Vaccinium macrocarpon) Supplementation on Lipid Peroxidation and Inflammation in Patients with Chronic Kidney Disease (Stages 3-4): A Randomized Controlled Trial Open
Background. Growing evidence suggests that bioactive compounds in berry fruits may mitigate inflammation in patients with chronic kidney disease (CKD). Objectives. To evaluate cranberry (Vaccinium macrocarpon) supplementation effects on mo…
View article: WCN24-1200 Antioxidant effects of a mix containing Curcuma longa L. and green propolis extract on patients undergoing hemodialysis: results from a randomised clinical trial
WCN24-1200 Antioxidant effects of a mix containing Curcuma longa L. and green propolis extract on patients undergoing hemodialysis: results from a randomised clinical trial Open
Oxidative stress is a common complication in chronic kidney disease (CKD) patients, increasing cardiovascular disease risk. Nutritional strategies are being proposed, including using bioactive compounds in foods to mitigate oxidative stres…
View article: WCN24-1231 Propolis supplementation decreases oxLDL plasma levels in patients undergoing hemodialysis
WCN24-1231 Propolis supplementation decreases oxLDL plasma levels in patients undergoing hemodialysis Open
Oxidative stress plays a central role in atherogenesis, a common chronic inflammatory disease in patients with chronic kidney disease (CKD), characterised by the accumulation of fatty substances into the vascular subintimal layer, mainly t…
View article: WCN24-701 EFFECTS OF SULFORAPHANE SUPPLEMENTATION ON PLASMA LEVELS OF UREMIC TOXINS IN PATIENTS UNDERGOING HEMODIALYSIS
WCN24-701 EFFECTS OF SULFORAPHANE SUPPLEMENTATION ON PLASMA LEVELS OF UREMIC TOXINS IN PATIENTS UNDERGOING HEMODIALYSIS Open
Patients with chronic kidney disease (CKD) present intestinal dysbiosis, which is associated with increased production of uremic toxins, such as indoxyl sulfate (IS), p-cresyl sulfate (p-CS), and indole-3-acetic acid (IAA). Nutritional str…
View article: WCN24-628 SULFORAPHANE SUPPLEMENTATION INCREASES HIGH-DENSITY LIPOPROTEIN CHOLESTEROL IN HEMODIALYSIS PATIENTS
WCN24-628 SULFORAPHANE SUPPLEMENTATION INCREASES HIGH-DENSITY LIPOPROTEIN CHOLESTEROL IN HEMODIALYSIS PATIENTS Open
Chronic Kidney Disease (CKD) patients have cardiovascular diseases as the main cause of death, with dyslipidemia being one of the main risk factors. In this context, non-pharmacological strategies such as the use of sulforaphane (SFN), an …
View article: WCN24-746 SUPPLEMENTATION WITH SULFORAPHANE INCREASES NRF2 mRNA EXPRESSION IN NONDIALYSIS CKD PATIENTS
WCN24-746 SUPPLEMENTATION WITH SULFORAPHANE INCREASES NRF2 mRNA EXPRESSION IN NONDIALYSIS CKD PATIENTS Open
Nuclear factor erythroid 2-related factor 2 (NRF2) is crucial in regulating cellular redox balance by increasing the expression of genes encoding antioxidant enzymes, such as heme oxygenase-1 (HO-1). However, patients with chronic kidney d…
View article: Is Trimethylamine N-oxide (TMAO) Associated with NF-κB mRNA Expression in Patients with Coronary Artery Disease?
Is Trimethylamine N-oxide (TMAO) Associated with NF-κB mRNA Expression in Patients with Coronary Artery Disease? Open
Background: Trimethylamine N-oxide (TMAO), a gut microbiota metabolite, is associated with cardiovascular disease (CVD) development. TMAO can trigger an inflammatory response by inducing the nuclear factor-kappa B (NF-κB) signaling cascade…
View article: Can curcumin supplementation break the vicious cycle of inflammation, oxidative stress, and uremia in patients undergoing peritoneal dialysis?
Can curcumin supplementation break the vicious cycle of inflammation, oxidative stress, and uremia in patients undergoing peritoneal dialysis? Open
Curcuminoid supplementation for twelve weeks attenuates lipid peroxidation and might reduce uremic toxin in patients with CKD undergoing PD. This study was registered on Clinicaltrials.gov as NCT04413266.
View article: S1 A phase 3b trial of gefapixant, a P2X3-receptor antagonist, in women with chronic cough and stress urinary incontinence
S1 A phase 3b trial of gefapixant, a P2X3-receptor antagonist, in women with chronic cough and stress urinary incontinence Open
Introduction and Objectives The majority of women with chronic cough experience cough-induced stress urinary incontinence (cSUI), or involuntary loss of urine on coughing1; however, this complication of cough is underappreciated. This mult…
View article: Evaluation of Bach1 <scp>mRNA</scp> expression in patients with chronic kidney disease: A preliminary study
Evaluation of Bach1 <span>mRNA</span> expression in patients with chronic kidney disease: A preliminary study Open
Introduction BTB and CNC homology 1 (Bach1) is a protein that antagonizes some actions of nuclear factor erythroid 2‐related factor‐2 (Nrf2), the master regulator of cytoprotective responses. Bach1 binds to genomic DNA and inhibits the syn…
View article: Cinnamon: an aromatic condiment applicable to chronic kidney disease
Cinnamon: an aromatic condiment applicable to chronic kidney disease Open
Cinnamon, a member of the Lauraceae family, has been widely used as a spice and traditional herbal medicine for centuries and hasshown beneficial effects in cardiovascular disease, obesity, and diabetes. However, its effectiveness as a the…
View article: Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis
Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis Open
The intervention with dark chocolate (70% cocoa) for two months reduced the plasma levels of TNF-α in patients with CKD on HD. In addition, it is essential to emphasise that chocolate intake did not increase the plasma levels of phosphorus…