Michael Carter
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View article: The XLZD Design Book: towards the next-generation liquid xenon observatory for dark matter and neutrino physics
The XLZD Design Book: towards the next-generation liquid xenon observatory for dark matter and neutrino physics Open
This report describes the experimental strategy and technologies for XLZD, the next-generation xenon observatory sensitive to dark matter and neutrino physics. In the baseline design, the detector will have an active liquid xenon target of…
View article: Should we stop doing comprehensive geriatric assessments in patients under 75 with cancer?
Should we stop doing comprehensive geriatric assessments in patients under 75 with cancer? Open
View article: TRLS-02 CEREBROSPINAL FLUID-DERIVED TUMOR REACTIVE T CELLS (CSF-TRT CELLS) FOR THE TREATMENT OF MELANOMA LEPTOMENINGEAL DISEASE.
TRLS-02 CEREBROSPINAL FLUID-DERIVED TUMOR REACTIVE T CELLS (CSF-TRT CELLS) FOR THE TREATMENT OF MELANOMA LEPTOMENINGEAL DISEASE. Open
BACKGROUND Leptomeningeal disease (LMD), a devastating complication of metastatic cancers, has a median survival of weeks to a few months. LMD incidence is highest in melanoma (5-25%), carrying the worst prognosis. Adoptive cell therapy (A…
View article: The impact of foraminotomy on patient-reported outcomes following 3+ level posterior cervical decompression and fusion for myeloradiculopathy
The impact of foraminotomy on patient-reported outcomes following 3+ level posterior cervical decompression and fusion for myeloradiculopathy Open
Objective: To evaluate whether patients with myeloradiculopathy experience better improvement in patient-reported outcome measures (PROMs) from the addition of foraminotomy in the setting of posterior cervical decompression and fusion (PCD…
View article: Outcomes of Cefazolin Administration in a Propensity Matched Cohort of Penicillin Allergic Patients Compared to Non-penicillin Allergic Patients
Outcomes of Cefazolin Administration in a Propensity Matched Cohort of Penicillin Allergic Patients Compared to Non-penicillin Allergic Patients Open
Study Design Retrospective cohort study. Objective To investigate whether cefazolin can be given to penicillin-allergic patients undergoing spine surgery without significantly increasing rates of allergic reactions. Additionally, we sought…
View article: Artificial Intelligence in Healthcare: Revolutionizing Diagnostics, Treatment, and Patient Care
Artificial Intelligence in Healthcare: Revolutionizing Diagnostics, Treatment, and Patient Care Open
Artificial intelligence (AI) is rapidly transforming healthcare by augmenting the accuracy, efficiency, and personalization of diagnostics, treatment planning, and patient management. Leveraging techniques such as deep learning, natural la…
View article: Measurements and models of enhanced recombination following inner-shell vacancies in liquid xenon
Measurements and models of enhanced recombination following inner-shell vacancies in liquid xenon Open
Electron-capture decays of Xe
View article: Dark Matter Search Results from <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mn>4.2</mml:mn><mml:mtext> </mml:mtext><mml:mtext> </mml:mtext><mml:mtext>Tonne</mml:mtext><mml:mtext>−</mml:mtext><mml:mtext>Years</mml:mtext></mml:mrow></mml:math> of Exposure of the LUX-ZEPLIN (LZ) Experiment
Dark Matter Search Results from of Exposure of the LUX-ZEPLIN (LZ) Experiment Open
We report results of a search for nuclear recoils induced by weakly interacting massive particle (WIMP) dark matter using the LUX-ZEPLIN (LZ) two-phase xenon time projection chamber. This analysis uses a total exposure of 4.2±0.1 tonne-yea…
View article: The Economic Gains from Breaking Boundaries: Reformulating Index Insurance Zones to Maximize Lower Tail Dependence
The Economic Gains from Breaking Boundaries: Reformulating Index Insurance Zones to Maximize Lower Tail Dependence Open
View article: Referral patterns for common surgical procedures in Ontario: a cross-sectional population-level study
Referral patterns for common surgical procedures in Ontario: a cross-sectional population-level study Open
Improving surgical wait times by coordinating surgical referrals will require approaches that address the structure of existing referral networks. Most physicians refer their patients to a very small number of surgeons, suggesting that ref…
View article: Two-neutrino double electron capture of <sup>124</sup>Xe in the first LUX-ZEPLIN exposure
Two-neutrino double electron capture of <sup>124</sup>Xe in the first LUX-ZEPLIN exposure Open
The broad physics reach of the LUX-ZEPLIN (LZ) experiment covers rare phenomena beyond the direct detection of dark matter. We report precise measurements of the extremely rare decay of 124 Xe through the process of two-neutrino double ele…
View article: Bivalent RSVpreF Vaccine in Adults 18 to &lt;60 Years Old With High-Risk Conditions
Bivalent RSVpreF Vaccine in Adults 18 to <60 Years Old With High-Risk Conditions Open
Background Older individuals and adults with certain chronic or immunocompromising health conditions are at increased risk of severe respiratory syncytial virus (RSV) disease. Methods In this phase 3 randomized trial of RSVpreF safety and …
View article: The XLZD Design Book: Towards the Next-Generation Liquid Xenon Observatory for Dark Matter and Neutrino Physics
The XLZD Design Book: Towards the Next-Generation Liquid Xenon Observatory for Dark Matter and Neutrino Physics Open
This report describes the experimental strategy and technologies for XLZD, the next-generation xenon observatory sensitive to dark matter and neutrino physics. In the baseline design, the detector will have an active liquid xenon target of…
View article: Utility of p53 Immunohistochemical Staining for Risk Stratification of Mantle Cell Lymphoma
Utility of p53 Immunohistochemical Staining for Risk Stratification of Mantle Cell Lymphoma Open
p53 IHC shows good concordance with NGS in MCL, with high specificity and moderate sensitivity for identifying inactivating TP53 mutations. Based on our findings, p53 IHC may be an efficient and cost-effective tool in risk stratific…
View article: Surgeon- and hospital-level variation in wait times for scheduled non-urgent surgery in Ontario, Canada: A cross-sectional population-based study
Surgeon- and hospital-level variation in wait times for scheduled non-urgent surgery in Ontario, Canada: A cross-sectional population-based study Open
Background Canadian health systems fare poorly in providing timely access to elective surgical care, which is crucial for quality, trust, and satisfaction. Methods We conducted a cross-sectional analysis of surgical wait times for adults r…
View article: TRSC-05 TUMOR REACTIVE T CELLS FROM THE CEREBROSPINAL FLUID IN MELANOMA LEPTOMENINGEAL DISEASE
TRSC-05 TUMOR REACTIVE T CELLS FROM THE CEREBROSPINAL FLUID IN MELANOMA LEPTOMENINGEAL DISEASE Open
BACKGROUND Leptomeningeal disease (LMD) is a devastating complication from cancer, with a median survival of 6-8 weeks. The incidence of LMD is highest in melanoma (5-25%) carrying the worst prognosis. Adoptive cell therapy (ACT) using tum…
View article: Testing Outlier Detection Algorithms for Identifying Early-Stage Solute Clusters in Atom Probe Tomography
Testing Outlier Detection Algorithms for Identifying Early-Stage Solute Clusters in Atom Probe Tomography Open
Atom probe tomography is commonly used to study solute clustering and precipitation in materials. However, standard techniques, such as the density based spatial clustering applications with noise (DBSCAN) perform poorly with respect to sm…
View article: Exploiting Vector Pattern Diversity of Molecular Scaffolds for Cheminformatics Tasks in Drug Discovery
Exploiting Vector Pattern Diversity of Molecular Scaffolds for Cheminformatics Tasks in Drug Discovery Open
Chemical diversity is challenging to describe objectively. Despite this, various notions of chemical diversity are used throughout the medicinal chemistry optimization process in drug discovery. In this work, we show the usefulness of cons…
View article: Breaking Boundaries: Lower Tail Dependence Can Triple the Economic Value of Index Insurance for Rural Households
Breaking Boundaries: Lower Tail Dependence Can Triple the Economic Value of Index Insurance for Rural Households Open
View article: In-hospital mortality trends after surgery for traumatic thoracolumbar injury: A national inpatient sample database study
In-hospital mortality trends after surgery for traumatic thoracolumbar injury: A national inpatient sample database study Open
Our study of nationwide, traumatic thoracolumbar fusion procedures from 2012 to 2017 in the NIS database found older, black patients were at increased risk for in-hospital mortality after surgery.
View article: On the Definition and Estimation of Economic Resilience Using Counterfactuals
On the Definition and Estimation of Economic Resilience Using Counterfactuals Open
View article: Can spooky stories engage people with history and heritage?
Can spooky stories engage people with history and heritage? Open
The English countryside is littered with the crumbling remains of ancient abbeys and priories, many of which are supposedly haunted.Professor Dale Townshend, from
View article: Social determinants of access to timely elective surgery in Ontario, Canada: a cross-sectional population level study
Social determinants of access to timely elective surgery in Ontario, Canada: a cross-sectional population level study Open
Social disadvantage had a small and inconsistent impact on receiving care within wait time targets. Future research should consider these differences as they relate to resource distribution and the organization of clinical service delivery.
View article: Long‐term outcome of epileptic dogs treated with implantable vagus nerve stimulators
Long‐term outcome of epileptic dogs treated with implantable vagus nerve stimulators Open
Background The long‐term effect of implantable vagus nerve stimulators (VNS) on seizures has not been evaluated in epileptic dogs. Objectives Report seizure frequency in medication‐resistant epileptic dogs before and after VNS implantation…
View article: Exploiting Vector Pattern Diversity of Molecular Scaffolds for Cheminformatics Tasks in Drug Discovery
Exploiting Vector Pattern Diversity of Molecular Scaffolds for Cheminformatics Tasks in Drug Discovery Open
Chemical diversity is challenging to describe objectively. Despite this, various notions of chemical diversity are used throughout the medicinal chemistry optimization process in drug discovery. In this work, we show the usefulness of cons…
View article: Exploiting Vector Pattern Diversity of Molecular Scaffolds for Cheminformatics Tasks in Drug Discovery
Exploiting Vector Pattern Diversity of Molecular Scaffolds for Cheminformatics Tasks in Drug Discovery Open
Data and code to accompany the paper: Exploiting Vector Pattern Diversity of Molecular Scaffolds for Cheminformatics Tasks in Drug Discovery.
View article: Reporting bias, not external focus
Reporting bias, not external focus Open
Evidence has ostensibly been accumulating over the past two decades suggesting that an external focus on the intended movement effect (e.g., on the golf club during a swing) is superior to an internal focus on body movements (e.g., on your…
View article: Changes in Management Based on X-rays after Pinning of Supracondylar Humerus Fractures: Rare, but More Common in Complex Injuries
Changes in Management Based on X-rays after Pinning of Supracondylar Humerus Fractures: Rare, but More Common in Complex Injuries Open
View article: LEVERAGING AI-BASED INTERVENTIONS TO ADDRESS CYBERBULLYING AMONG CHILDREN: A RIGHTS-BASED PERSPECTIVE
LEVERAGING AI-BASED INTERVENTIONS TO ADDRESS CYBERBULLYING AMONG CHILDREN: A RIGHTS-BASED PERSPECTIVE Open
One in three Internet users worldwide are children, and yet children are still insufficiently consulted on Internet governance-related matters as well as with respect to safety design decisions in online environments. Following the adoptio…
View article: Data-Driven Two-stage Appointment Radiotherapy Scheduling Model for Resource Optimization at a Tertiary Cancer Center
Data-Driven Two-stage Appointment Radiotherapy Scheduling Model for Resource Optimization at a Tertiary Cancer Center Open
Background: The timely delivery of radiotherapy (RT) is crucial to cancer care, and excessive delays in RT have been associated with detrimental oncological and psychological outcomes. Prior to receiving RT on treatment units (Linear accel…