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A modiolar-pillar gradient in auditory-nerve dendritic length: a novel post-synaptic contribution to dynamic range? Open

Serhii Kostrikov, Jens Hjortkjær, Torsten Dau, Gabriel Corfas, Leslie D. Liberman , et al. · 2024

Auditory-nerve fibers (ANFs) from a given cochlear region can vary in threshold sensitivity by up to 60 dB, corresponding to a 1000-fold difference in stimulus level, although each fiber innervates a single inner hair cell (IHC) via a sing…

Lack of Oncomodulin Increases ATP-Dependent Calcium Signaling and Susceptibility to Noise in Adult Mice Open

Yang Yang, Jing‐Yi Jeng, Kaitlin Murtha, Leslie K. Climer, Federico Ceriani , et al. · 2024

Tight regulation of Ca 2+ is crucial for the function of cochlear outer hair cells (OHCs). Dysregulation of Ca 2+ homeostasis in OHCs is associated with impaired hearing and contributes to increased vulnerability to insults such as noise e…

On the Difficulty Predicting Word Recognition Performance After Cochlear Implantation Open

Ryan A. Bartholomew, Samantha E. Hoffman, Amy F. Juliano, Pei‐zhe Wu, Yan Zhao , et al. · 2024

Hypothesis Preimplantation word scores cannot reliably predict postimplantation outcomes. Background To date, there is no model based on preoperative data that can reliably predict the postoperative outcomes of cochlear implantation in the…

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2024

Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5 - 15 thousand terminally differentiated hair cells, …

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2024

Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5 - 15 thousand terminally differentiated hair cells, …

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2023

Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5 - 15 thousand terminally differentiated hair cells, …

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2023

This is the dataset behind the Hair Cell Analysis Toolbox (HCAT)

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2023

Our sense of hearing is mediated by cochlear hair cells, localized within the sensory epithelium called the organ of Corti. There are two types of hair cells in the cochlea, which are organized in one row of inner hair cells and three rows…

Ultrastructure of noise-induced cochlear synaptopathy Open

Daniel J. Moverman, Leslie D. Liberman, Stephan Kräemer, Gabriel Corfas, M. Charles Liberman · 2023

Overexposure to noise can eliminate synaptic connections between inner hair cells (IHCs) and auditory nerve fibers (ANFs), even if hair-cell function recovers. This noise-induced synaptopathy has been extensively studied in confocal micros…

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2023

This is the dataset behind the Hair Cell Analysis Toolbox (HCAT)

Supporting-cell vs. hair-cell survival in the human cochlea: Implications for regenerative therapies Open

Charanjeet Kaur, McKayla Van Orden, Jennifer T. O’Malley, Pei‐zhe Wu, M. Charles Liberman · 2023

Animal studies have shown that the supporting-cells surviving in the organ of Corti after cochlear insult can be transdifferentiated into hair cells as a treatment for sensorineural hearing loss. Clinical trials of small-molecule therapeut…

Three-dimensional quantification of fibrosis and ossification after cochlear implantation via virtual re-sectioning: Potential implications for residual hearing Open

Alexander Geerardyn, Mingxing Zhu, Pei‐zhe Wu, Jennifer T. O’Malley, Joseph B. Nadol , et al. · 2022

Imaging of excised cochleae by micro-CT: staining, liquid embedding, and image modalities Open

Jannis Justus Schaeper, M. Charles Liberman, Tim Salditt · 2022

Assessing the complex three-dimensional (3D) structure of the cochlea is crucial to understand fundamental aspects of signal transduction in the inner ear and is a prerequisite for the development of novel cochlear implants (CIs). Phase-co…

Dopaminergic and cholinergic innervation in the mouse cochlea after noise-induced or age-related synaptopathy Open

Kiera E. Grierson, Tyler Hickman, M. Charles Liberman · 2022

Inner hair cell synapse density influences auditory processing Open

Lingchao Ji, Beatriz C. Borges, David T. Martel, Calvin Wu, M. Charles Liberman , et al. · 2022

Loss of synapses between spiral ganglion neurons and inner hair cells (IHC synaptopathy), leads to an auditory neuropathy called hidden hearing loss (HHL) characterized by normal auditory thresholds but reduced amplitude of sound-evoked au…

Cochlear Neurotrophin-3 overexpression at mid-life prevents age-related cochlear synaptopathy and slows age-related hearing loss Open

Luis Cassinotti, Lingchao Ji, Beatriz C. Borges, Nathan D. Cass, Aditi S. Desai , et al. · 2022

Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This progressive pathology often has psychological and medical comorbidities, including social isolation, depression, and cognitive decline. Despite ARHL…

Human vestibular schwannoma reduces density of auditory nerve fibers in the osseous spiral lamina Open

Maura C. Eggink, Johan H. M. Frijns, Jessica E. Sagers, Jennifer T. O’Malley, M. Charles Liberman , et al. · 2022

Probing adaptation and spontaneous firing in human auditory-nerve fibers with far-field peri-stimulus time responses Open

Antoine Huet, Charlène Batrel, Xavier Dubernard, Jean‐Charles Kleiber, Gilles Desmadryl , et al. · 2021

Information in sound stimuli is conveyed from sensory hair cells to the cochlear nuclei by the firing of auditory nerve fibers (ANFs). For obvious ethical reasons, single unit recordings from the cochlear nerve have never been performed in…

Correlations between cochlear pathophysiology and behavioral measures of temporal and spatial processing in noise exposed macaques Open

Chase A. Mackey, Jennifer McCrate, Kaitlyn S. MacDonald, Jessica Feller, Leslie W. Liberman , et al. · 2020

Idiopathic Sudden Sensorineural Hearing Loss: Speech Intelligibility Deficits Following Threshold Recovery Open

Masahiro Okada, Aravindakshan Parthasarathy, D. Bradley Welling, M. Charles Liberman, Stéphane F. Maison · 2020

Objectives: This retrospective study tests the hypothesis that patients who have recovered from idiopathic sudden sensorineural hearing loss (SSNHL) show deficits in word recognition tasks that cannot be entirely explained by a loss in aud…

Age-Related Hearing Loss Is Dominated by Damage to Inner Ear Sensory Cells, Not the Cellular Battery That Powers Them Open

Pei‐zhe Wu, Jennifer T. O’Malley, Victor De Gruttola, M. Charles Liberman · 2020

Age-related hearing loss arises from irreversible damage in the inner ear, where sound is transduced into electrical signals. Prior human studies suggested that sensory-cell loss is rarely the cause; correspondingly, animal work has implic…

Hidden hearing loss: Primary neural degeneration in the noise-damaged and aging cochlea Open

M. Charles Liberman · 2020

In acquired sensorineural hearing loss, the hearing impairment arises mainly from damage to cochlear hair cells or the sensory fibers of the auditory nerve that innervate them. Hair cell loss or damage is well captured by the changes in th…

Cochlear Efferent Innervation Is Sparse in Humans and Decreases with Age Open

Leslie D. Liberman, M. Charles Liberman · 2019

The mammalian cochlea is innervated by two cholinergic feedback systems called the medial olivocochlear (MOC) and lateral olivocochlear (LOC) pathways, which send control signals from the brainstem back to the outer hair cells and auditory…

Middle Ear Muscle Reflex and Word Recognition in “Normal-Hearing” Adults: Evidence for Cochlear Synaptopathy? Open

Anita M. Mepani, Sarah A. Kirk, Kenneth E. Hancock, Kara Bennett, Victor De Gruttola , et al. · 2019

Objectives: Permanent threshold elevation after noise exposure, ototoxic drugs, or aging is caused by loss of sensory cells; however, animal studies show that hair cell loss is often preceded by degeneration of synapses between sensory cel…

Chronic Conductive Hearing Loss Is Associated With Speech Intelligibility Deficits in Patients With Normal Bone Conduction Thresholds Open

Masahiro Okada, D. Bradley Welling, M. Charles Liberman, Stéphane F. Maison · 2019

Objectives: The main objective of this study is to determine whether chronic sound deprivation leads to poorer speech discrimination in humans. Design: We reviewed the audiologic profile of 240 patients presenting normal and symmetrical bo…

Morphological Immaturity of the Neonatal Organ of Corti and Associated Structures in Humans Open

Sebastiaan W. F. Meenderink, Christopher A. Shera, Michelle D. Valero, M. Charles Liberman, Carolina Abdala · 2019

Translating animal models to human therapeutics in noise-induced and age-related hearing loss Open

Sharon G. Kujawa, M. Charles Liberman · 2019

Cochlear Synaptopathy Changes Sound-Evoked Activity Without Changing Spontaneous Discharge in the Mouse Inferior Colliculus Open

Luke A. Shaheen, M. Charles Liberman · 2018

Tinnitus and hyperacusis are life-disrupting perceptual abnormalities that are often preceded by acoustic overexposure. Animal models of overexposure have suggested a link between these phenomena and neural hyperactivity, i.e., elevated sp…

Effects of cochlear synaptopathy on spontaneous and sound-evoked activity in the mouse inferior colliculus Open

Luke A. Shaheen, M. Charles Liberman · 2018

Tinnitus and hyperacusis are life-disrupting perceptual abnormalities that are often preceded by acoustic overexposure. Animal models of overexposure have suggested a link between these phenomena and neural hyperactivity, i.e. elevated spo…

Blast-induced cochlear synaptopathy in chinchillas Open

Tyler Hickman, Christopher J. Smalt, Johanna Bobrow, Thomas F. Quatieri, M. Charles Liberman · 2018

When exposed to continuous high-level noise, cochlear neurons are more susceptible to damage than hair cells (HCs): exposures causing temporary threshold shifts (TTS) without permanent HC damage can destroy ribbon synapses, permanently sil…

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