M. Chepkwony
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View article: 417. Expanding the cattle reference graph genome
417. Expanding the cattle reference graph genome Open
Recent studies have highlighted several key advantages of graph genomes over standard linear reference genomes. These advantages include improvements in read mapping rates at divergent loci and the ability to more accurately call structura…
View article: Optical mapping compendium of structural variants across global cattle breeds
Optical mapping compendium of structural variants across global cattle breeds Open
Structural variants (SV) have been linked to important bovine disease phenotypes, but due to the difficulty of their accurate detection with standard sequencing approaches, their role in shaping important traits across cattle breeds is lar…
View article: Longitudinal transcriptome analysis of cattle infected with Theileria parva
Longitudinal transcriptome analysis of cattle infected with Theileria parva Open
The apicomplexan cattle parasite Theileria parva is a major barrier to improving the livelihoods of smallholder farmers in Africa, killing over one million cattle on the continent each year. Although exotic breeds not native to Africa are …
View article: Optical mapping compendium of structural variants across global cattle breeds
Optical mapping compendium of structural variants across global cattle breeds Open
Structural variants (SV) have been linked to important bovine disease phenotypes, but due to the difficulty of their accurate detection with standard sequencing approaches, their role in shaping important traits across cattle breeds is lar…
View article: A locus conferring tolerance to Theileria infection in African cattle
A locus conferring tolerance to Theileria infection in African cattle Open
East Coast fever, a tick-borne cattle disease caused by the Theileria parva parasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a coh…
View article: Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes
Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes Open
Theileria parva is the causative agent of East Coast fever and Corridor disease, which are fatal, economically important diseases of cattle in eastern, central and southern Africa. Improved methods of control of the diseases are urgently r…
View article: Clinical Evaluation of Corridor Disease in Bos indicus (Boran) Cattle Naturally Infected With Buffalo-Derived Theileria parva
Clinical Evaluation of Corridor Disease in Bos indicus (Boran) Cattle Naturally Infected With Buffalo-Derived Theileria parva Open
Corridor disease (CD) is a fatal condition of cattle caused by buffalo-derived Theileria parva . Unlike the related condition, East Coast fever, which results from infection with cattle-derived T. parva , CD has not been extensively studie…
View article: Field validation of clinical and laboratory diagnosis of wildebeest associated malignant catarrhal fever in cattle
Field validation of clinical and laboratory diagnosis of wildebeest associated malignant catarrhal fever in cattle Open
Clinical diagnosis was demonstrated to be an effective method to identify affected animals although animals may be incorrectly classified resulting in financial loss. The study revealed indirect ELISA as a poor test and nested PCR to be a …
View article: <i>Theileria parva</i>antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines
<i>Theileria parva</i>antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines Open
The extent of sequence diversity among the genes encoding 10 antigens (Tp1–10) known to be recognized by CD8 + T lymphocytes from cattle immune to Theileria parva was analysed. The sequences were derived from parasites in 23 buffalo-derive…