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View article: A simulation framework for the <i>LiteBIRD</i> instruments
A simulation framework for the <i>LiteBIRD</i> instruments Open
LiteBIRD , the Lite (Light) satellite for the study of B-mode polarization and Inflation from cosmic background Radiation Detection, is a space mission focused on primordial cosmology and fundamental physics. In this paper, we present the …
View article: A substantial proportion of subjects with adolescent idiopathic scoliosis display spinal and peripheral proprioceptive deficits
A substantial proportion of subjects with adolescent idiopathic scoliosis display spinal and peripheral proprioceptive deficits Open
Aims Adolescent idiopathic scoliosis (AIS) is considered a multifactorial disease, and proprioceptive deficit (PD) is evident as a potential associated factor. However, existing studies have indicated that only a subgroup of scoliotic adol…
View article: The risk and dynamics of unprecedented summer monsoon rainfall over Southeast China under the current climate
The risk and dynamics of unprecedented summer monsoon rainfall over Southeast China under the current climate Open
Under the influence of Asian summer monsoon, extremely heavy summer rainfall could occur in Southeast China, causing catastrophic social-economic impacts to the region. However, due to limited historical records, it is difficult to anticip…
View article: Biosynthesis of H <sub>2</sub> S and Siderophores Targeting Gram‐Negative Bacterial Resistance to Reactive Oxygen Species
Biosynthesis of H <sub>2</sub> S and Siderophores Targeting Gram‐Negative Bacterial Resistance to Reactive Oxygen Species Open
Reactive oxygen species (ROS) are a promising alternative bactericide. However, it is questioned that bacteria can potentially develop resistance to ROS, similar to their resistance against antibiotics and silver. Herein, it is reported th…
View article: Impacts of ultrasonic osteotomy devices on bone regeneration and brain activity in a mouse model
Impacts of ultrasonic osteotomy devices on bone regeneration and brain activity in a mouse model Open
Ultrasonic osteotomy devices (UODs) have emerged as precise bone-cutting instruments with soft tissue-sparing benefits; yet their impact on bone healing and adjacent neural tissue remains underexplored. This study aimed to investigate the …
View article: BQ323636.1 Employs the AR-CCRK Axis to Modulate the Expression of KU70 to Interfere with Non-Homologous End Joining Mediated DNA Repair Mechanism
BQ323636.1 Employs the AR-CCRK Axis to Modulate the Expression of KU70 to Interfere with Non-Homologous End Joining Mediated DNA Repair Mechanism Open
BQ323636.1 (BQ) is a splice variant of NCOR2. Its overexpression is associated with endocrine therapy and chemoresistance in estrogen receptor-positive (ER+ve) breast cancer. This study investigates how BQ overexpression drives doxorubicin…
View article: Triple Stranded Porphyrin Nanobelts
Triple Stranded Porphyrin Nanobelts Open
Molecular nanobelts are fascinating analogues of carbon nanotubes. Their rigid geometries and strongly coupled π-electrons have the potential to generate a wavefunction resembling that of a quantum ring. Here we report the synthesis of tri…
View article: Osteoporosis in Adult Patients Undergoing Spinal Reconstructive Surgery: Associated Complications and Management
Osteoporosis in Adult Patients Undergoing Spinal Reconstructive Surgery: Associated Complications and Management Open
Study Design Literature review. Objectives To provide an overview of the complications associated with and management strategies for adult patients with osteoporosis requiring spinal reconstructive surgery. Emphasis will be placed on scree…
View article: An interdisciplinary, randomized, single-blind evaluation of state-of-the-art large language models for their implications and risks in medical diagnosis and management
An interdisciplinary, randomized, single-blind evaluation of state-of-the-art large language models for their implications and risks in medical diagnosis and management Open
Background State-of-the-art (SOTA) large language models (LLMs) are poised to revolutionize clinical medicine by transforming diagnostic, therapeutic, and interdisciplinary reasoning. Despite their promising capabilities, rigorous benchmar…
View article: The Splice Variant of the NCOR2 Gene BQ323636.1 Modulates ACSL4 Expression to Enhance Fatty Acid Metabolism and Support of Tumor Growth in Breast Cancer
The Splice Variant of the NCOR2 Gene BQ323636.1 Modulates ACSL4 Expression to Enhance Fatty Acid Metabolism and Support of Tumor Growth in Breast Cancer Open
BQ323636.1 (BQ), a splice variant of NCOR2, is associated with endocrine therapy resistance and poorer prognosis in ER-positive breast cancer. This study investigates the role of BQ in modulating lipid metabolism to support tumor growth. R…
View article: Institution-Based Quality and Safety Improvement Initiatives in Spine Surgery: A Scoping Review
Institution-Based Quality and Safety Improvement Initiatives in Spine Surgery: A Scoping Review Open
Background: Improving patient safety and healthcare quality is necessary to advance value-based health care. Spine surgery is complex, entailing joint efforts between different disciplines. This scoping review aimed to map the research on …
View article: Long-term follow-up of non‑neurologic and neurologic complications after complex adult spinal deformity surgery: results from the Scoli-RISK-1 study
Long-term follow-up of non‑neurologic and neurologic complications after complex adult spinal deformity surgery: results from the Scoli-RISK-1 study Open
During the study period, 25(32.5%) patients experienced 35 surgery-related complications, of which 23(65.7%) were major. Rod fracture with pseudarthrosis was the most common major, surgery-related complication. Neurologic complications wer…
View article: A Zero-Shot LLM Framework for Automatic Assignment Grading in Higher Education
A Zero-Shot LLM Framework for Automatic Assignment Grading in Higher Education Open
Automated grading has become an essential tool in education technology due to its ability to efficiently assess large volumes of student work, provide consistent and unbiased evaluations, and deliver immediate feedback to enhance learning.…
View article: Fibrocyte enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity
Fibrocyte enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity Open
Fibrotic remodeling of nucleus pulposus (NP) leads to structural and mechanical anomalies of intervertebral discs that prone to degeneration, leading to low back pain incidence and disability. Emergence of fibroblastic cells in disc degene…
View article: Normative values of spinal and peripheral proprioception in position sense among healthy adolescents and young adults
Normative values of spinal and peripheral proprioception in position sense among healthy adolescents and young adults Open
Establishing normative values and understanding how proprioception varies among body parts is crucial. However, the variability across individuals, especially adolescents, makes it difficult to establish norms. This prevents further invest…
View article: A case series in vertebral body tethering results in improvement in coronal Cobb angle but deterioration in axial rotation: a 3-dimensional analysis
A case series in vertebral body tethering results in improvement in coronal Cobb angle but deterioration in axial rotation: a 3-dimensional analysis Open
This is the first case series to use 3D radiographic digital measurements to reveal apical axial rotation progression in thoracic curves despite improved coronal curvature. While larger scales studies with longer follow-up are needed to ve…
View article: Multi-dimensional optimisation of the scanning strategy for the LiteBIRD space mission
Multi-dimensional optimisation of the scanning strategy for the LiteBIRD space mission Open
Large angular scale surveys in the absence of atmosphere are essential for measuring the primordial B-mode power spectrum of the Cosmic Microwave Background (CMB). Since this proposed measurement is about three to four orders of magnitude …
View article: Five days of inpatient scoliosis-specific exercises improve preoperative spinal flexibility and facilitate curve correction of patients with rigid idiopathic scoliosis
Five days of inpatient scoliosis-specific exercises improve preoperative spinal flexibility and facilitate curve correction of patients with rigid idiopathic scoliosis Open
Preoperative spine flexibility plays a key role in the intraoperative treatment course of severe scoliosis. In this cohort study, we examined the effects of 5 day inpatient scoliosis-specific exercise (SSE) on the spinal flexibility of pat…
View article: Increased lengthening frequency does not adversely affect the EOSQ scores in magnetically controlled growing rod surgeries in 133 subjects followed to final fusion
Increased lengthening frequency does not adversely affect the EOSQ scores in magnetically controlled growing rod surgeries in 133 subjects followed to final fusion Open
Purpose Magnetically Controlled Growing Rod (MCGR) allows frequent outpatient rod lengthening when treating Early Onset Scoliosis (EOS) patients. But there is lack of expert consensus on the optimal MCGR lengthening interval. EOS 24-Item Q…
View article: Opioid Use Prior to Adult Spine Deformity Correction Surgery is Associated With Worse Pre- and Postoperative Back Pain and Prolonged Opioid Demands
Opioid Use Prior to Adult Spine Deformity Correction Surgery is Associated With Worse Pre- and Postoperative Back Pain and Prolonged Opioid Demands Open
Study Design Prospective multicenter database post-hoc analysis. Objectives Opioids are frequently prescribed for painful spinal conditions to provide pain relief and to allow for functional improvement, both before and after spine surgery…