Michele Ciccarelli
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View article: Unraveling the Risk Factors for Type II Diabetes in severe Obese patients with indication for Bariatric Surgery: retrospective analysis.
Unraveling the Risk Factors for Type II Diabetes in severe Obese patients with indication for Bariatric Surgery: retrospective analysis. Open
View article: Diagnostic Accuracy of Coronary CT Angiography in Ruling Out Significant Coronary Artery Disease in Candidates for Transcatheter Aortic Valve Replacement
Diagnostic Accuracy of Coronary CT Angiography in Ruling Out Significant Coronary Artery Disease in Candidates for Transcatheter Aortic Valve Replacement Open
Obstructive coronary artery disease (CAD) is common in patients undergoing transcatheter aortic valve implantation (TAVI). While invasive coronary angiography (ICA) is the gold standard for coronary evaluation, coronary computed tomography…
View article: Mindfulness-Based Interventions for Chronic Pulmonary Diseases: A Systematic Review of Effects on Anxiety, Depression, Stress, Dyspnea, and Quality of Life
Mindfulness-Based Interventions for Chronic Pulmonary Diseases: A Systematic Review of Effects on Anxiety, Depression, Stress, Dyspnea, and Quality of Life Open
(1) Background: Chronic pulmonary diseases (CPDs), such as COPD, asthma, and interstitial lung disease, are often accompanied by psychological distress and reduced quality of life. Mindfulness-Based Interventions (MBIs), including digital …
View article: Evaluation of the Effectiveness of a Cardiac Telerehabilitation Program in Chronic Heart Failure: Design and Rationale of the TELEREHAB-HF Study
Evaluation of the Effectiveness of a Cardiac Telerehabilitation Program in Chronic Heart Failure: Design and Rationale of the TELEREHAB-HF Study Open
Background: Despite strong guideline recommendations, participation in cardiac rehabilitation (CR) among patients with chronic heart failure (CHF) remains low due to logistical, geographical, and psychosocial barriers. Telerehabilitation m…
View article: Prevalence and Risk Indicators of Peri‐Implant Diseases and Buccal Soft‐Tissue Dehiscence: A Cross‐Sectional Study From a University‐Based Cohort
Prevalence and Risk Indicators of Peri‐Implant Diseases and Buccal Soft‐Tissue Dehiscence: A Cross‐Sectional Study From a University‐Based Cohort Open
Aim To assess the prevalence of peri‐implant diseases and buccal peri‐implant soft‐tissue dehiscence (PISTD) and to identify the associated risk indicators. Methods Patients previously rehabilitated with implant‐supported rehabilitations a…
View article: Mitochondrial accumulation of GRK2 as a protective mechanism against hypoxia-induced endothelial dysfunction
Mitochondrial accumulation of GRK2 as a protective mechanism against hypoxia-induced endothelial dysfunction Open
View article: Triglyceride-glucose index threshold for cardiovascular mortality in hypertensive individuals - URRAH project
Triglyceride-glucose index threshold for cardiovascular mortality in hypertensive individuals - URRAH project Open
View article: Cardiovascular Nursing in Rehabilitative Cardiology: A Review
Cardiovascular Nursing in Rehabilitative Cardiology: A Review Open
Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, necessitating comprehensive management and prevention strategies. Rehabilitative cardiology, also known as cardiac rehabilitation (CR), is a multidisciplinary …
View article: Remote Rehabilitation and Virtual Reality Interventions Using Motion Sensors for Chronic Low Back Pain: A Systematic Review of Biomechanical, Pain, Quality of Life, and Adherence Outcomes
Remote Rehabilitation and Virtual Reality Interventions Using Motion Sensors for Chronic Low Back Pain: A Systematic Review of Biomechanical, Pain, Quality of Life, and Adherence Outcomes Open
Background: Chronic low back pain (CLBP) is a leading cause of disability, impacting quality of life (QoL), function, and work productivity. Traditional rehabilitation faces challenges in accessibility and adherence. Remote rehabilitation …
View article: Epigenetic mechanisms underlying the beneficial effects of cardiac rehabilitation. An overview from the working groups of “cellular and molecular biology of the heart” and “cardiac rehabilitation and cardiovascular prevention” of the Italian Society of Cardiology (SIC)
Epigenetic mechanisms underlying the beneficial effects of cardiac rehabilitation. An overview from the working groups of “cellular and molecular biology of the heart” and “cardiac rehabilitation and cardiovascular prevention” of the Italian Society of Cardiology (SIC) Open
The benefits of cardiac rehabilitation (CR) have been demonstrated in patients after myocardial infarction (MI), and in patients with chronic heart failure (HF). The core components of the CR program include improvement in exercise toleran…
View article: GRK2 and Mitochondrial Dynamics in Cardiovascular Health and Disease
GRK2 and Mitochondrial Dynamics in Cardiovascular Health and Disease Open
G protein-coupled receptors (GPCRs) represent a family of membrane proteins that regulate several cellular processes. Among the GPCRs, G protein-coupled receptor kinases (GRKs) regulate downstream signaling pathways and receptor desensitiz…
View article: Exploring the Role of Voice Assistants in Managing Noncommunicable Diseases: A Systematic Review on Clinical, Behavioral Outcomes, Quality of Life, and User Experiences
Exploring the Role of Voice Assistants in Managing Noncommunicable Diseases: A Systematic Review on Clinical, Behavioral Outcomes, Quality of Life, and User Experiences Open
Background: Non-communicable diseases (NCDs) represent a leading cause of global mortality, demanding innovative approaches to management. Voice assistants (VAs) have emerged as promising tools in healthcare, offering support for self-mana…
View article: Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study
Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study Open
Both IR and SUA/GFR ratio independently predict CV mortality, regardless of age, gender, BMI, diabetes, hypertension and statin use. The joint effect of the TG/HDL-C ratio and the elevated SUA/GFR ratio was greater than the presence of eac…
View article: Predictive Value of Insulin Resistance and GFR-Adjusted Uric Acid Levels on Cardiovascular Mortality: The Urrah Study
Predictive Value of Insulin Resistance and GFR-Adjusted Uric Acid Levels on Cardiovascular Mortality: The Urrah Study Open
Background Insulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway and contributing to IR, while IR is a known predictor for the development of hyperu…
View article: Retrospective Study on Short-Term Reverse Cardiac Remodeling in Obese Patients Undergoing Sleeve Gastrectomy
Retrospective Study on Short-Term Reverse Cardiac Remodeling in Obese Patients Undergoing Sleeve Gastrectomy Open
Severe obesity is closely associated with an increased risk of comorbidities and alterations in cardiac structure and function. The primary objective of this study was to investigate cardiovascular (CV) risk factors and ventricular remodel…
View article: The effects of Dapagliflozin in a real-world population of HFrEF patients with different hemodynamic profiles: worse is better
The effects of Dapagliflozin in a real-world population of HFrEF patients with different hemodynamic profiles: worse is better Open
View article: Plasma miR‐1‐3p levels predict severity in hospitalized COVID‐19 patients
Plasma miR‐1‐3p levels predict severity in hospitalized COVID‐19 patients Open
Background and Purpose Accumulating evidence suggests circulating microRNAs (miRNAs) are important regulators of biological processes involved in COVID‐19 complications. We sought to assess whether circulating miRNAs are associated with CO…
View article: An explainable model for predicting Worsening Heart Failure based on genetic programming
An explainable model for predicting Worsening Heart Failure based on genetic programming Open
Heart Failure (HF) poses a challenge for our health systems, and early detection of Worsening HF (WHF), defined as a deterioration in symptoms and clinical and instrumental signs of HF, is vital to improving prognosis. Predicting WHF in a …
View article: The Role of Adiponectin and Leptin in Fibro-Calcific Aortic Valve Disease: A Systematic Review and Meta-Analysis
The Role of Adiponectin and Leptin in Fibro-Calcific Aortic Valve Disease: A Systematic Review and Meta-Analysis Open
Background: Fibro-calcific aortic valve disease (FCAVD) is a progressive disorder characterized by the thickening and calcification of the aortic valve, eventually leading to aortic stenosis. Adiponectin and leptin, known for their anti-in…
View article: Technological Developments, Exercise Training Programs, and Clinical Outcomes in Cardiac Telerehabilitation in the Last Ten Years: A Systematic Review
Technological Developments, Exercise Training Programs, and Clinical Outcomes in Cardiac Telerehabilitation in the Last Ten Years: A Systematic Review Open
Background: Cardiovascular diseases (CVDs) are associated with very high rates of re-hospitalization and mortality worldwide, so the complexity of these pathologies requires frequent access to hospital facilities. The guidelines also empha…
View article: Changes in the Lipid Asset of HIV/HCV Patients after a Successful Course of Direct-Acting Antivirals
Changes in the Lipid Asset of HIV/HCV Patients after a Successful Course of Direct-Acting Antivirals Open
Background: Highly Active Antiretroviral Therapy (HAART) for HIV infection and Direct-Acting Antivirals (DAA) for HCV infection currently represent the main treatment options for HIV/HCV co-infected patients. However, HAART has been associ…
View article: Serum Uric Acid, Hypertriglyceridemia, and Carotid Plaques: A Sub-Analysis of the URic Acid Right for Heart Health (URRAH) Study
Serum Uric Acid, Hypertriglyceridemia, and Carotid Plaques: A Sub-Analysis of the URic Acid Right for Heart Health (URRAH) Study Open
High levels of serum uric acid (SUA) and triglycerides (TG) might promote high-cardiovascular-risk phenotypes, including subclinical atherosclerosis. An interaction between plaques xanthine oxidase (XO) expression, SUA, and HDL-C has been …
View article: Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function
Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function Open
Cardiovascular disease (CVD) is the leading cause of morbimortality in Europe and worldwide. CVD imposes a heterogeneous spectrum of cardiac remodelling, depending on the insult nature, that is, pressure or volume overload, ischaemia, arrh…
View article: Serum parathormone, vitamin D and cardiovascular risk factors and markers: A pilot study
Serum parathormone, vitamin D and cardiovascular risk factors and markers: A pilot study Open
In a population at high cardiovascular risk, vitamin D and PTH levels were not directly associated with blood pressure values and HMOD. Secondary hyperparathyroidism due to vitamin D deficiency is associated with carotid atherosclerosis in…
View article: The favourable alliance between CardioMEMS and levosimendan in patients with advanced heart failure
The favourable alliance between CardioMEMS and levosimendan in patients with advanced heart failure Open
Aims We report the results of a real‐world study based on heart failure (HF) patients' continuous remote monitoring strategy using the CardioMEMS system to assess the impact of this device on healthcare outcomes, costs, and patients' manag…
View article: Using AI to identify left ventricular ejection fraction from the ECG: The SOLOMAX (SOciaL NetwOrk of MedicAl Experiences) project
Using AI to identify left ventricular ejection fraction from the ECG: The SOLOMAX (SOciaL NetwOrk of MedicAl Experiences) project Open
Aim: The interest in machine learning-based algorithms in the cardiovascular field is rapidly growing, especially for diagnostic and prognostic purposes. Recent evidence has demonstrated that certain electrocardiographic (ECG) parameters a…
View article: Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study
Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study Open
View article: Telerehabilitation: a solution for patients after hip fracture?
Telerehabilitation: a solution for patients after hip fracture? Open
- Hip fracture is the most common cause of hospitalization in frail geriatric subjects due to osteoporosis and recurrent falls. The clinical practice guidelines for rehabilitation after surgery in patients with hip fractures recommend to s…
View article: Chronic Kidney Disease with Mineral Bone Disorder and Vascular Calcification: An Overview
Chronic Kidney Disease with Mineral Bone Disorder and Vascular Calcification: An Overview Open
Chronic kidney disease (CKD) is a global health issue with a rising prevalence, affecting 697.5 million people worldwide. It imposes a substantial burden, contributing to 35.8 million disability-adjusted life years (DALYs) and 1.2 million …
View article: Triglyceride-glucose Index and Mortality in a Large Regional-based Italian Database (URRAH Project)
Triglyceride-glucose Index and Mortality in a Large Regional-based Italian Database (URRAH Project) Open
Purpose Recently, a novel index [the triglyceride-glucose (TyG) index]) was considered a surrogate marker of insulin resistance (IR); in addition, it was estimated to be a better expression of IR than widely used tools. Few and heterogeneo…